Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxisomal targeting signal 1 receptor

Gene

PEX5

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal 1 receptor
Short name:
PTS1 receptor
Short name:
PTS1R
Alternative name(s):
PTS1-BP
Peroxin-5
Peroxisomal C-terminal targeting signal import receptor
Peroxisome receptor 1
Gene namesi
Name:PEX5
ORF Names:RCJMB04_1g17
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Peroxisome membrane By similarity; Peripheral membrane protein By similarity

  • Note: Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002848821 – 645Peroxisomal targeting signal 1 receptorAdd BLAST645

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki11Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)Sequence analysis

Keywords - PTMi

Thioester bond, Ubl conjugation

Proteomic databases

PaxDbiQ5ZMQ9.
PRIDEiQ5ZMQ9.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036282.

Structurei

3D structure databases

ProteinModelPortaliQ5ZMQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati340 – 373TPR 1Add BLAST34
Repeati375 – 407TPR 2Add BLAST33
Repeati408 – 441TPR 3Add BLAST34
Repeati459 – 491TPR 4Add BLAST33
Repeati494 – 527TPR 5Add BLAST34
Repeati529 – 561TPR 6Add BLAST33
Repeati563 – 595TPR 7Add BLAST33

Sequence similaritiesi

Contains 7 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1125. Eukaryota.
ENOG410XQ6Q. LUCA.
HOGENOMiHOG000158146.
HOVERGENiHBG053575.
InParanoidiQ5ZMQ9.
KOiK13342.
PhylomeDBiQ5ZMQ9.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZMQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMRELVEPE CGGSNPLLKL AGHFTQDKAL RQEGLQGSLG WPPGAAGAAA
60 70 80 90 100
VSKPLGVASE DELVGEFLQG QNAPLLSHAP QTLRWMTCWL RCKRLNSPAF
110 120 130 140 150
RQAPQRAPGV AALALSENWT QEFLAAADTA GDVSSDYNEA DWSQEFIAEV
160 170 180 190 200
TDPLSVSPAK WAEEYLEQSE EKLWLGESED QSLADKWYEE YQPEDDLKKT
210 220 230 240 250
ASDFLSKVDD PKLNSSEFLK FVRQIGDGRV SIEANQVTHR DQDQAEQWAT
260 270 280 290 300
EFMQQQGSSD AWVDQFARSG NLSALDTEFE QAKTAVESDV DFWDKLQAEW
310 320 330 340 350
EEMAKRDAEA HPWLTDYDDL SSSSYDKGYQ FEEDNPMRDH PDAFEEGRKR
360 370 380 390 400
LEEGDLPNAV LLFEAAVQQK PDHMEAWQYL GTTQAENEQE LLAISALRRC
410 420 430 440 450
LELQPGNLTA LMALAVSFTN ESLQKQACET LRDWLHHKPA YAHLLEKAPE
460 470 480 490 500
ENASETNLGT SKRVLGSLLS DSLFVEVKEL FLAAVRSNPS TVDPDVQCGL
510 520 530 540 550
GVLFNLSGEY EKAVDCFSAA LSVRPNDHLL WNKLGATLAN GNRSEEAVAA
560 570 580 590 600
YRRALELQPG YIRSRYNLGI SCINLGAHRE AVEHFLEALH MQQKSRGPRG
610 620 630 640
QQGAMSDNIW STLRMALSML GQSDLYGAAD AHDLPTLLQA FGLQQ
Length:645
Mass (Da):71,791
Last modified:November 23, 2004 - v1
Checksum:i71CDB78A8140B9DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719325 mRNA. Translation: CAG30984.1.
RefSeqiNP_001012836.1. NM_001012818.2.
UniGeneiGga.19020.

Genome annotation databases

GeneIDi418299.
KEGGigga:418299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719325 mRNA. Translation: CAG30984.1.
RefSeqiNP_001012836.1. NM_001012818.2.
UniGeneiGga.19020.

3D structure databases

ProteinModelPortaliQ5ZMQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036282.

Proteomic databases

PaxDbiQ5ZMQ9.
PRIDEiQ5ZMQ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi418299.
KEGGigga:418299.

Organism-specific databases

CTDi5830.

Phylogenomic databases

eggNOGiKOG1125. Eukaryota.
ENOG410XQ6Q. LUCA.
HOGENOMiHOG000158146.
HOVERGENiHBG053575.
InParanoidiQ5ZMQ9.
KOiK13342.
PhylomeDBiQ5ZMQ9.

Miscellaneous databases

PROiQ5ZMQ9.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEX5_CHICK
AccessioniPrimary (citable) accession number: Q5ZMQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: November 23, 2004
Last modified: October 5, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.