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Protein

AP-2 complex subunit mu

Gene

AP2M1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei339Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei341Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei343Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei352Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei354Phosphatidylinositol lipid headgroupBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processEndocytosis, Protein transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-GGA-177504 Retrograde neurotrophin signalling
R-GGA-190873 Gap junction degradation
R-GGA-196025 Formation of annular gap junctions
R-GGA-2132295 MHC class II antigen presentation
R-GGA-416993 Trafficking of GluR2-containing AMPA receptors
R-GGA-437239 Recycling pathway of L1
R-GGA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-GGA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-GGA-8856828 Clathrin-mediated endocytosis
R-GGA-8866427 VLDLR internalisation and degradation
R-GGA-8964038 LDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
AP-2 complex subunit mu
Alternative name(s):
AP-2 mu chain
Clathrin assembly protein complex 2 mu medium chain
Clathrin coat assembly protein AP50
Clathrin coat-associated protein AP50
HA2 50 kDa subunit
Mu2-adaptin
Plasma membrane adaptor AP-2 50 kDa protein
Gene namesi
Name:AP2M1
ORF Names:RCJMB04_1h23
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003188931 – 433AP-2 complex subunit muAdd BLAST433

Proteomic databases

PaxDbiQ5ZMP6
PRIDEiQ5ZMP6

Expressioni

Gene expression databases

BgeeiENSGALG00000008432

Interactioni

Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit and beta-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013724

Structurei

3D structure databases

ProteinModelPortaliQ5ZMP6
SMRiQ5ZMP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 432MHDPROSITE-ProRule annotationAdd BLAST265

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0937 Eukaryota
ENOG410XPFS LUCA
GeneTreeiENSGT00530000062779
HOGENOMiHOG000173246
HOVERGENiHBG050516
InParanoidiQ5ZMP6
KOiK11826
OMAiSWRKADV
OrthoDBiEOG091G06XI
PhylomeDBiQ5ZMP6
TreeFamiTF300722

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR022775 AP_mu_sigma_su
IPR001392 Clathrin_mu
IPR018240 Clathrin_mu_CS
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF005992 Clathrin_mu, 1 hit
PRINTSiPR00314 CLATHRINADPT
SUPFAMiSSF49447 SSF49447, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990 CLAT_ADAPTOR_M_1, 1 hit
PS00991 CLAT_ADAPTOR_M_2, 1 hit
PS51072 MHD, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZMP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGGLFIYNH KGEVLISRVY RDDIGRNAVD AFRVNVIHAR QQVRSPVTNI
60 70 80 90 100
ARTSFFHVKR SNIWLAAVTK QNVNAAMVFE FLYKMCDVMT AYFGKISEEN
110 120 130 140 150
IKNNFVLIYE LLDEILDFGY PQNSETGALK TFITQQGIKS QTKEEQSQIT
160 170 180 190 200
SQVTGQIGWR REGIKYRRNE LFLDVLESVN LLMSPQGQVL SAHVSGRVVM
210 220 230 240 250
KSYLSGMPEC KFGMNDKIVI EKQGKGTADE TGKSGKQSIA IDDCTFHQCV
260 270 280 290 300
RLSKFDSERS ISFIPPDGEF ELMRYRTTKD IILPFRVIPL VREVGRTKLE
310 320 330 340 350
VKVVIKSNFK PSLLAQKIEV RIPTPLNTSG VQVICMKGKA KYKASENAIV
360 370 380 390 400
WKIKRMAGMK ESQISAEIEL LPTNDKKKWA RPPISMNFEV PFAPSGLKVR
410 420 430
YLKVFEPKLN YSDHDVIKWV RYIGRSGIYE TRC
Length:433
Mass (Da):49,389
Last modified:November 23, 2004 - v1
Checksum:iD546E1BBCE90C796
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719338 mRNA Translation: CAG30997.1
RefSeqiNP_001072962.1, NM_001079494.1
XP_015146933.1, XM_015291447.1
UniGeneiGga.15365

Genome annotation databases

EnsembliENSGALT00000013739; ENSGALP00000013724; ENSGALG00000008432
GeneIDi770246
KEGGigga:770246

Similar proteinsi

Entry informationi

Entry nameiAP2M1_CHICK
AccessioniPrimary (citable) accession number: Q5ZMP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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