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Protein

AP-2 complex subunit mu

Gene

AP2M1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei339Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei341Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei343Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei352Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei354Phosphatidylinositol lipid headgroupBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Endocytosis, Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-GGA-171052. LDL-mediated lipid transport.
R-GGA-177504. Retrograde neurotrophin signalling.
R-GGA-190873. Gap junction degradation.
R-GGA-196025. Formation of annular gap junctions.
R-GGA-2132295. MHC class II antigen presentation.
R-GGA-3928665. EPH-ephrin mediated repulsion of cells.
R-GGA-416993. Trafficking of GluR2-containing AMPA receptors.
R-GGA-437239. Recycling pathway of L1.
R-GGA-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
R-GGA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-GGA-8856828. Clathrin-mediated endocytosis.
R-GGA-8866427. VLDLR internalisation and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-2 complex subunit mu
Alternative name(s):
AP-2 mu chain
Clathrin assembly protein complex 2 mu medium chain
Clathrin coat assembly protein AP50
Clathrin coat-associated protein AP50
HA2 50 kDa subunit
Mu2-adaptin
Plasma membrane adaptor AP-2 50 kDa protein
Gene namesi
Name:AP2M1
ORF Names:RCJMB04_1h23
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003188931 – 433AP-2 complex subunit muAdd BLAST433

Proteomic databases

PaxDbiQ5ZMP6.

Expressioni

Gene expression databases

BgeeiENSGALG00000008432.

Interactioni

Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit and beta-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013724.

Structurei

3D structure databases

ProteinModelPortaliQ5ZMP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 432MHDPROSITE-ProRule annotationAdd BLAST265

Sequence similaritiesi

Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0937. Eukaryota.
ENOG410XPFS. LUCA.
GeneTreeiENSGT00530000062779.
HOGENOMiHOG000173246.
HOVERGENiHBG050516.
InParanoidiQ5ZMP6.
KOiK11826.
OMAiPPLSMNF.
OrthoDBiEOG091G06XI.
PhylomeDBiQ5ZMP6.
TreeFamiTF300722.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZMP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGGLFIYNH KGEVLISRVY RDDIGRNAVD AFRVNVIHAR QQVRSPVTNI
60 70 80 90 100
ARTSFFHVKR SNIWLAAVTK QNVNAAMVFE FLYKMCDVMT AYFGKISEEN
110 120 130 140 150
IKNNFVLIYE LLDEILDFGY PQNSETGALK TFITQQGIKS QTKEEQSQIT
160 170 180 190 200
SQVTGQIGWR REGIKYRRNE LFLDVLESVN LLMSPQGQVL SAHVSGRVVM
210 220 230 240 250
KSYLSGMPEC KFGMNDKIVI EKQGKGTADE TGKSGKQSIA IDDCTFHQCV
260 270 280 290 300
RLSKFDSERS ISFIPPDGEF ELMRYRTTKD IILPFRVIPL VREVGRTKLE
310 320 330 340 350
VKVVIKSNFK PSLLAQKIEV RIPTPLNTSG VQVICMKGKA KYKASENAIV
360 370 380 390 400
WKIKRMAGMK ESQISAEIEL LPTNDKKKWA RPPISMNFEV PFAPSGLKVR
410 420 430
YLKVFEPKLN YSDHDVIKWV RYIGRSGIYE TRC
Length:433
Mass (Da):49,389
Last modified:November 23, 2004 - v1
Checksum:iD546E1BBCE90C796
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719338 mRNA. Translation: CAG30997.1.
RefSeqiNP_001072962.1. NM_001079494.1.
XP_015146933.1. XM_015291447.1.
UniGeneiGga.15365.

Genome annotation databases

EnsembliENSGALT00000013739; ENSGALP00000013724; ENSGALG00000008432.
GeneIDi770246.
KEGGigga:770246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719338 mRNA. Translation: CAG30997.1.
RefSeqiNP_001072962.1. NM_001079494.1.
XP_015146933.1. XM_015291447.1.
UniGeneiGga.15365.

3D structure databases

ProteinModelPortaliQ5ZMP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013724.

Proteomic databases

PaxDbiQ5ZMP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000013739; ENSGALP00000013724; ENSGALG00000008432.
GeneIDi770246.
KEGGigga:770246.

Organism-specific databases

CTDi1173.

Phylogenomic databases

eggNOGiKOG0937. Eukaryota.
ENOG410XPFS. LUCA.
GeneTreeiENSGT00530000062779.
HOGENOMiHOG000173246.
HOVERGENiHBG050516.
InParanoidiQ5ZMP6.
KOiK11826.
OMAiPPLSMNF.
OrthoDBiEOG091G06XI.
PhylomeDBiQ5ZMP6.
TreeFamiTF300722.

Enzyme and pathway databases

ReactomeiR-GGA-171052. LDL-mediated lipid transport.
R-GGA-177504. Retrograde neurotrophin signalling.
R-GGA-190873. Gap junction degradation.
R-GGA-196025. Formation of annular gap junctions.
R-GGA-2132295. MHC class II antigen presentation.
R-GGA-3928665. EPH-ephrin mediated repulsion of cells.
R-GGA-416993. Trafficking of GluR2-containing AMPA receptors.
R-GGA-437239. Recycling pathway of L1.
R-GGA-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
R-GGA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-GGA-8856828. Clathrin-mediated endocytosis.
R-GGA-8866427. VLDLR internalisation and degradation.

Miscellaneous databases

PROiQ5ZMP6.

Gene expression databases

BgeeiENSGALG00000008432.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP2M1_CHICK
AccessioniPrimary (citable) accession number: Q5ZMP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 23, 2004
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.