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Protein

Prohibitin-2

Gene

PHB2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin-2
Gene namesi
Name:PHB2
ORF Names:RCJMB04_1i23
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Mitochondrion inner membrane By similarity
  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Prohibitin-2PRO_0000328653Add
BLAST

Proteomic databases

PaxDbiQ5ZMN3.
PRIDEiQ5ZMN3.

Interactioni

Protein-protein interaction databases

BioGridi691830. 1 interaction.
STRINGi9031.ENSGALP00000023446.

Structurei

3D structure databases

ProteinModelPortaliQ5ZMN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 4931Necessary for transcriptional repressionBy similarityAdd
BLAST
Regioni150 – 17425Necessary for transcriptional repressionBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili190 – 23748Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the prohibitin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3090. Eukaryota.
COG0330. LUCA.
HOGENOMiHOG000205692.
HOVERGENiHBG004457.
InParanoidiQ5ZMN3.
KOiK17081.
PhylomeDBiQ5ZMN3.

Family and domain databases

InterProiIPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view]
PANTHERiPTHR23222. PTHR23222. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00679. PROHIBITIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZMN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSLKDLAG RLPAGPRGVG TALKLLLGAG ALAYGVRESV FIVEGGQRAI
60 70 80 90 100
FFNRIGGVQQ DTILAEGLHF RIPWFQYPII YDIRARPRKI SSPTGSKDLQ
110 120 130 140 150
MVNISLRVLT RPNAAELPSM YQRLGLDYEE RVLPSIVNEV LKSVVAKFNA
160 170 180 190 200
SQLITQRAQV SLLIRRELTE RAKDFSLILD DVAITELSFS REYTAAVEAK
210 220 230 240 250
QVAQQEAQRA QFLVEKAKQE QKQKIVQAEG EATAAKMLGE ALSRNPGYIK
260 270 280 290 300
LRKIRAAQNI SKTIAGSQNR VYLTADNLVL NLQDEGFTRG SDSLLLKQGK

K
Length:301
Mass (Da):33,337
Last modified:November 23, 2004 - v1
Checksum:iB43E2C8178F21BB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719351 mRNA. Translation: CAG31010.1.
RefSeqiNP_001074354.1. NM_001080885.1.
UniGeneiGga.34471.

Genome annotation databases

GeneIDi771124.
KEGGigga:771124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719351 mRNA. Translation: CAG31010.1.
RefSeqiNP_001074354.1. NM_001080885.1.
UniGeneiGga.34471.

3D structure databases

ProteinModelPortaliQ5ZMN3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi691830. 1 interaction.
STRINGi9031.ENSGALP00000023446.

Proteomic databases

PaxDbiQ5ZMN3.
PRIDEiQ5ZMN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi771124.
KEGGigga:771124.

Organism-specific databases

CTDi11331.

Phylogenomic databases

eggNOGiKOG3090. Eukaryota.
COG0330. LUCA.
HOGENOMiHOG000205692.
HOVERGENiHBG004457.
InParanoidiQ5ZMN3.
KOiK17081.
PhylomeDBiQ5ZMN3.

Miscellaneous databases

NextBioi20921328.
PROiQ5ZMN3.

Family and domain databases

InterProiIPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view]
PANTHERiPTHR23222. PTHR23222. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00679. PROHIBITIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiPHB2_CHICK
AccessioniPrimary (citable) accession number: Q5ZMN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 23, 2004
Last modified: January 20, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.