Q5ZMN0 (AN32B_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member B

Gene names

Name:	ANP32B
ORF Names:	RCJMB04_1j7

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome By similarity.
Subcellular location	Nucleus By similarity.
Domain	Histone binding is mediated by the concave surface of the LRR region By similarity.
Sequence similarities	Belongs to the ANP32 family. Contains 4 LRR (leucine-rich) repeats. Contains 1 LRRCT domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Leucine-rich repeat Repeat
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Acidic leucine-rich nuclear phosphoprotein 32 family member B		PRO_0000280063
Regions
	Repeat	16 – 40	25	LRR 1
	Repeat	43 – 64	22	LRR 2
	Repeat	65 – 87	23	LRR 3
	Repeat	89 – 110	22	LRR 4
	Domain	123 – 161	39	LRRCT
	Compositional bias	146 – 262	117	Asp/Glu-rich (highly acidic)

Sequences

	Sequence		Length	Mass (Da)
	Q5ZMN0 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: A59C2750DA50D3DB	FASTA	262	29,944
	10 20 30 40 50 60 MEMKKRLTLE LRNKKPGEVK ELVLDNCRSD DGKIVGLSSD FENLEFLSMI NVNLLSISNL 70 80 90 100 110 120 PKLNKLRKLE LSDNRISGGL EVLAERTPNL THLNLSGNKI KDINTLEPLK KLPNLHSLDL 130 140 150 160 170 180 FNCEVTMLIN YRESVFTLLP QLTYLDGFDA DEQEAPDSDP EADGDGLEDE YENGEGEEEE 190 200 210 220 230 240 DDDEEDDLDE EVIDEEDDED DDLEGEEEED GVDDEEEDEE EDGEDEEDDE ADDDLPRGEK 250 260 RKRNLEDEGE EDPEDEEDDE DD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.
[2]	"The Anp32 family of proteins containing leucine-rich repeats." Matilla A., Radrizzani M. Cerebellum 4:7-18(2005) [PubMed: 15895553] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ719354 mRNA. Translation: CAG31013.1.
IPI	IPI00601960.
RefSeq	NP_001026105.1. NM_001030934.1.
UniGene	Gga.47306.
3D structure databases
ProteinModelPortal	Q5ZMN0.
SMR	Q5ZMN0. Positions 1-161.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000002401; ENSGALP00000002398; ENSGALG00000001580.
GeneID	420087.
KEGG	gga:420087.
Organism-specific databases
CTD	10541.
Phylogenomic databases
GeneTree	ENSGT00560000077130.
HOVERGEN	HBG053102.
InParanoid	Q5ZMN0.
OMA	MLINYRE.
OrthoDB	EOG4K9BDJ.
PhylomeDB	Q5ZMN0.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR003603. U2A'_phosphoprotein32A_C. [Graphical view]
SMART	SM00446. LRRcap. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AN32B_CHICK

Accession

Primary (citable) accession number: Q5ZMN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	November 23, 2004
Last modified:	September 21, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program