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Protein

Serine/arginine-rich splicing factor 1

Gene

SRSF1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 1
Alternative name(s):
Splicing factor, arginine/serine-rich 1
Gene namesi
Name:SRSF1
Synonyms:SFRS1
ORF Names:RCJMB04_1l5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus speckle By similarity

  • Note: In nuclear speckles. Shuttles between the nucleus and the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 257256Serine/arginine-rich splicing factor 1PRO_0000223505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5ZML3.
PRIDEiQ5ZML3.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008849.

Structurei

3D structure databases

ProteinModelPortaliQ5ZML3.
SMRiQ5ZML3. Positions 6-102, 107-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 9176RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini121 – 19575RRM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi92 – 11322Gly-rich (hinge region)Add
BLAST

Sequence similaritiesi

Belongs to the splicing factor SR family.Sequence analysis
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0105. Eukaryota.
COG0724. LUCA.
HOVERGENiHBG002295.
InParanoidiQ5ZML3.
KOiK12890.
PhylomeDBiQ5ZML3.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZML3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGGVIRGP AGNNDCRIYV GNLPPDIRTK DIEDVFYKYG AIRDIDLKNR
60 70 80 90 100
RGGPPFAFVE FEDPRDAEDA VYGRDGYDYD GYRLRVEFPR SGRGTGRGGG
110 120 130 140 150
GGGGGGAPRG RYGPPSRRSE YRVIVSGLPP SGSWQDLKDH MREAGDVCYA
160 170 180 190 200
DVFRDGTGVV EFVRKEDMTY AVRKLDNTKF RSHEGETAYI RVKVDGPRSP
210 220 230 240 250
SYGRSRSRSV VVAEAVVGAT AEAAVIPQEE AEDLHATLPA TADPDLVHKR

SLALIFL
Length:257
Mass (Da):28,060
Last modified:January 23, 2007 - v3
Checksum:i7EF82AE44F9B73C8
GO

Mass spectrometryi

Molecular mass is 32326±2 Da from positions 2 - 257. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719371 mRNA. Translation: CAG31030.1.
RefSeqiNP_001107213.1. NM_001113741.1.
UniGeneiGga.4490.
Gga.48488.

Genome annotation databases

GeneIDi772264.
KEGGigga:772264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719371 mRNA. Translation: CAG31030.1.
RefSeqiNP_001107213.1. NM_001113741.1.
UniGeneiGga.4490.
Gga.48488.

3D structure databases

ProteinModelPortaliQ5ZML3.
SMRiQ5ZML3. Positions 6-102, 107-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008849.

Proteomic databases

PaxDbiQ5ZML3.
PRIDEiQ5ZML3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi772264.
KEGGigga:772264.

Organism-specific databases

CTDi6426.

Phylogenomic databases

eggNOGiKOG0105. Eukaryota.
COG0724. LUCA.
HOVERGENiHBG002295.
InParanoidiQ5ZML3.
KOiK12890.
PhylomeDBiQ5ZML3.

Miscellaneous databases

NextBioi20922455.
PROiQ5ZML3.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CBImported.
    Tissue: Bursa of FabriciusImported.
  2. "Proteomic analysis of the Gallus gallus embryo at stage-29 of development."
    Agudo D., Gomez-Esquer F., Diaz-Gil G., Martinez-Arribas F., Delcan J., Schneider J., Palomar M.A., Linares R.
    Proteomics 5:4946-4957(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, MASS SPECTROMETRY.
    Tissue: Embryo1 Publication.

Entry informationi

Entry nameiSRSF1_CHICK
AccessioniPrimary (citable) accession number: Q5ZML3
Secondary accession number(s): P84170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: January 23, 2007
Last modified: April 13, 2016
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.