Reviewed, UniProtKB/Swiss-Prot Q5ZMJ4 (GLPK5_CHICK)

Names and origin

Protein names

Recommended name:
    Putative glycerol kinase 5
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase

Gene names

Name:	GK5
ORF Names:	RCJMB04_1n17

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	517 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate.
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 517	517	Putative glycerol kinase 5		PRO_0000323756
Regions
	Nucleotide binding	431 – 436	6	ATP By similarity
Sites
	Binding site	23	1	Substrate By similarity
	Binding site	93	1	Substrate By similarity
	Binding site	270	1	Substrate By similarity
	Binding site	292	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZMJ4-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 3E88E5495BE38EFD	FASTA	517	57,261
	10 20 30 40 50 60 MPCGQPGSGA APALYVVGVD VGSTTVKCHV YDRAAGVRGS SCRKVESLYP RPGWVELDPE 70 80 90 100 110 120 VLWSQFVGVI KEAVQAAGLH MRQVAALGIS TQRSTFITWH KRTGKPFHNF ISWQDLRSAE 130 140 150 160 170 180 LVNSWNRSLL LKVIHVIFTV LHFFTGNDRY LAPSVLTFST QQTSMKLSWV FKNIPEADEA 190 200 210 220 230 240 AKKNNCCFGT VDTWLLYRLT KGSVFATDYS NASSTGVFEP FTKCWNPTLC HLLSIPMSIY 250 260 270 280 290 300 PPVKDTSFNF GSADSEIFGV PVPIMALVAD QQSAMFGECC FQPGDVKLTM GTGGFWNVNT 310 320 330 340 350 360 GGNLFASHKG LYPLIGWKIG EEVVYLTEGS MSNIGTTIKW AQDINLFTNV DETAKMARSI 370 380 390 400 410 420 VDSQGVCFVP GFQVSANDPY LCASFMGLKP TTTRNHLVRA ILESVAFRNK QLFDIIVKKV 430 440 450 460 470 480 RIPLQTVRAD GGVSNNSFVM QMTSDLINKK IEKPSNTDMS SLGAAFLAGL ASGLWTDKEQ 490 500 510 LKKLRQIETV FEPQKDEKEY KPAMDTWMRA VKCSLHW

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:RESEARCH006.1-RESEARCH006.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ719390 mRNA. Translation: CAG31049.1.
IPI	IPI00582887.
RefSeq	NP_001026477.1.
UniGene	Gga.22519
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ZMJ4.
Genome annotation databases
Ensembl	ENSGALT00000004307; ENSGALP00000004298; ENSGALG00000002729; Gallus gallus. [Genome view]
GeneID	424779.
KEGG	gga:424779.
Organism-specific databases
CTD	424779.
Phylogenomic databases
HOGENOM	Q5ZMJ4.
HOVERGEN	Q5ZMJ4.
OMA	HKLTKGS.
Enzyme and pathway databases
BRENDA	2.7.1.30. 4.
Family and domain databases
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
PROSITE	PS00933. FGGY_KINASES_1. False negative. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK5_CHICK

Accession

Primary (citable) accession number: Q5ZMJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	November 23, 2004
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)