Q5ZMG0 (DOPD_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-dopachrome decarboxylase
EC=4.1.1.84

Alternative name(s):
D-dopachrome tautomerase

Gene names

Name:	DDT
ORF Names:	RCJMB04_2c16

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) By similarity.
Catalytic activity	D-dopachrome = 5,6-dihydroxyindole + CO2.
Subunit structure	Homotrimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the MIF family.

Ontologies

Keywords
Biological process	Melanin biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	melanin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	D-dopachrome decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 118	117	D-dopachrome decarboxylase		PRO_0000337234
Amino acid modifications
	Modified residue	2	1	N-acetylproline By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZMG0 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 5F7A61E65C09A4A8	FASTA	118	12,835
	10 20 30 40 50 60 MPFVELETNL PAERLPPGLP LKLCEATATI LGKPAERVNV TVRSGMPMVL AGSAEPCAQL 70 80 90 100 110 LVSSIGVVGS AQQNQGHSAR FFDFLTTELG LGPERIVIRF YPLEPWQIGK NRTVMTFL

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ719424 mRNA. Translation: CAG31083.1.
IPI	IPI00589721.
RefSeq	NP_001025838.1. NM_001030667.1.
UniGene	Gga.7005.
3D structure databases
HSSP	HSSP built from PDB template 1DPT based on UniProtKB P30046.
ProteinModelPortal	Q5ZMG0.
SMR	Q5ZMG0. Positions 2-118.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	416937.
KEGG	gga:416937.
Organism-specific databases
CTD	1652.
Phylogenomic databases
eggNOG	veNOG20672.
GeneTree	ENSGT00530000063544.
HOGENOM	HBG629499.
HOVERGEN	HBG003240.
InParanoid	Q5ZMG0.
OrthoDB	EOG46T330.
Family and domain databases
InterPro	IPR001398. Macrophage_inhib_fac. IPR019829. Macrophage_inhib_fac_CS. IPR014347. Tautomerase. [Graphical view]
Gene3D	G3DSA:3.30.429.10. Tautomerase. 1 hit.
KO	K10028.
PANTHER	PTHR11954. MIF. 1 hit.
Pfam	PF01187. MIF. 1 hit. [Graphical view]
ProDom	PD004816. Macrophage_inhib_fac. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF55331. SSF55331. 1 hit.
PROSITE	PS01158. MIF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DOPD_CHICK

Accession

Primary (citable) accession number: Q5ZMG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 23, 2004
Last modified:	November 16, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program