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Q5ZME2

- MDHC_CHICK

UniProt

Q5ZME2 - MDHC_CHICK

Protein

Malate dehydrogenase, cytoplasmic

Gene

MDH1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei92 – 921SubstrateBy similarity
    Binding sitei98 – 981SubstrateBy similarity
    Binding sitei105 – 1051NADBy similarity
    Binding sitei112 – 1121NADBy similarity
    Binding sitei131 – 1311SubstrateBy similarity
    Binding sitei162 – 1621SubstrateBy similarity
    Active sitei187 – 1871Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 177NADBy similarity
    Nucleotide bindingi129 – 1313NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. cellular carbohydrate metabolic process Source: InterPro
    3. gluconeogenesis Source: Reactome
    4. malate metabolic process Source: InterPro
    5. small molecule metabolic process Source: Reactome
    6. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    ReactomeiREACT_115534. Gluconeogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase, cytoplasmic (EC:1.1.1.37)
    Alternative name(s):
    Cytosolic malate dehydrogenase
    Gene namesi
    Name:MDH1
    ORF Names:RCJMB04_2g5
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 3

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334Malate dehydrogenase, cytoplasmicPRO_0000226738Add
    BLAST

    Proteomic databases

    PaxDbiQ5ZME2.
    PRIDEiQ5ZME2.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi682121. 1 interaction.
    IntActiQ5ZME2. 1 interaction.
    STRINGi9031.ENSGALP00000014374.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZME2.
    SMRiQ5ZME2. Positions 3-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.Curated

    Phylogenomic databases

    eggNOGiCOG0039.
    GeneTreeiENSGT00530000063410.
    HOGENOMiHOG000220953.
    HOVERGENiHBG006340.
    InParanoidiQ5ZME2.
    KOiK00025.
    OMAiNCLIASK.
    OrthoDBiEOG78H3TM.
    PhylomeDBiQ5ZME2.
    TreeFamiTF105826.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR011274. Malate_DH_NAD-dep_euk.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
    TIGR01758. MDH_euk_cyt. 1 hit.
    PROSITEiPS00068. MDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5ZME2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEPIRVLVT GAAGQIAYSL LYSIAKGDVF GKEQPLVLVL LDITPMMTVL    50
    EGVVMELQDC ALPLLREVIP TDKEEVAFKD LDIAILVGSM PRREGMERKD 100
    LLKANVKIFK SQGAALDKYA KKTVKVVVVG NPANTNCLIA SKSAPSIPKE 150
    NFSCLTRLDH NRAKSQIALK LGVTSNDVKN VIIWGNHSST QYPDVNHAKV 200
    NVKGKEVGVY EAIKDDSWLK GDFILTVQQR GAAVIKARKL SSAMSAAKAI 250
    CDHVRDIWFG TPAGEFVSMG VISDGNSYGV PEDLLYSFPV VIKDKTWKFV 300
    EGLPINDFSR EKMDLTAKEL TEEKETAVEF LSSA 334
    Length:334
    Mass (Da):36,543
    Last modified:November 23, 2004 - v1
    Checksum:i2AD5D831DC812332
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ719442 mRNA. Translation: CAG31101.1.
    RefSeqiNP_001006395.1. NM_001006395.1.
    UniGeneiGga.1141.

    Genome annotation databases

    EnsembliENSGALT00000014390; ENSGALP00000014374; ENSGALG00000008858.
    GeneIDi421281.
    KEGGigga:421281.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ719442 mRNA. Translation: CAG31101.1 .
    RefSeqi NP_001006395.1. NM_001006395.1.
    UniGenei Gga.1141.

    3D structure databases

    ProteinModelPortali Q5ZME2.
    SMRi Q5ZME2. Positions 3-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 682121. 1 interaction.
    IntActi Q5ZME2. 1 interaction.
    STRINGi 9031.ENSGALP00000014374.

    Proteomic databases

    PaxDbi Q5ZME2.
    PRIDEi Q5ZME2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000014390 ; ENSGALP00000014374 ; ENSGALG00000008858 .
    GeneIDi 421281.
    KEGGi gga:421281.

    Organism-specific databases

    CTDi 4190.

    Phylogenomic databases

    eggNOGi COG0039.
    GeneTreei ENSGT00530000063410.
    HOGENOMi HOG000220953.
    HOVERGENi HBG006340.
    InParanoidi Q5ZME2.
    KOi K00025.
    OMAi NCLIASK.
    OrthoDBi EOG78H3TM.
    PhylomeDBi Q5ZME2.
    TreeFami TF105826.

    Enzyme and pathway databases

    Reactomei REACT_115534. Gluconeogenesis.

    Miscellaneous databases

    NextBioi 20824070.
    PROi Q5ZME2.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR011274. Malate_DH_NAD-dep_euk.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    TIGR01758. MDH_euk_cyt. 1 hit.
    PROSITEi PS00068. MDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiMDHC_CHICK
    AccessioniPrimary (citable) accession number: Q5ZME2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3