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Protein

Stress-70 protein, mitochondrial

Gene

HSPA9

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Stress-70 protein, mitochondrial
Alternative name(s):
75 kDa glucose-regulated protein
Short name:
GRP-75
Heat shock 70 kDa protein 9
Gene namesi
Name:HSPA9By similarity
ORF Names:RCJMB04_2m8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4848MitochondrionBy similarityAdd
BLAST
Chaini49 – 675627Stress-70 protein, mitochondrialPRO_0000223503Add
BLAST

Proteomic databases

PaxDbiQ5ZM98.
PRIDEiQ5ZM98.

Interactioni

Subunit structurei

Interacts with FXN. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).By similarity

Protein-protein interaction databases

BioGridi677728. 1 interaction.
STRINGi9031.ENSGALP00000003717.

Structurei

3D structure databases

ProteinModelPortaliQ5ZM98.
SMRiQ5ZM98. Positions 57-582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Sequence analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0102. Eukaryota.
COG0443. LUCA.
HOGENOMiHOG000228135.
HOVERGENiHBG051845.
InParanoidiQ5ZM98.
KOiK04043.
PhylomeDBiQ5ZM98.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZM98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISASRAAAR LPLLLPRGGP VPAVPGLAQT FWNGLSQNVL RAASSRKYAS
60 70 80 90 100
EAIKGAVIGI DLGTTNSCVA VMEGKQAKVL ENSEGARTTP SVVAFTADGE
110 120 130 140 150
RLVGMPAKRQ AVTNPHNTFY ATKRLIGRRF DDSEVKKDIK NVPFKIVRAS
160 170 180 190 200
NGDAWVEAHG KLYSPSQIGA FVLMKMKETA ENYLGHPAKN AVITVPAYFN
210 220 230 240 250
DSQRQATKDA GQISGLNVLR VINEPTAAAL AYGLDKSEDK IIAVYDLGGG
260 270 280 290 300
TFDISILEIQ KGVFEVKSTN GDTFLGGEDF DQALLQYIVK EFKRETSVDL
310 320 330 340 350
TKDNMALQRV REASEKAKCE LSSSVQTDIN LPYLTMDASG PKHLNMKLSR
360 370 380 390 400
SQFEGIVADL IKRTVAPCQK AMQDAEVSKS DIGEVILVGG MTRMPKVQQT
410 420 430 440 450
VQDLFGRAPS KAVNPDEAVA IGAAIQGGVL AGDVTDVLLL DVTPLSLGIE
460 470 480 490 500
TLGGVFTKLI NRNTTIPTKK SQVFSTAADG QTQVEIKVCQ GEREMASDNK
510 520 530 540 550
LLGQFTLVGI PPAPRGVPQI EVTFDIDANG IVHVSAKDKG TGREQQIVIQ
560 570 580 590 600
SSGGLSKDEI ENMVKNAEKY AEEDRRRKER VEAVNLAEGI IHDTESKMEE
610 620 630 640 650
FKDQLPADEC NKLKEEIAKM RELLARKDTE TGENIRQAAT SLQQASLKLF
660 670
EMAYKKMASE RESSGSSGDQ KEEKQ
Length:675
Mass (Da):73,192
Last modified:November 23, 2004 - v1
Checksum:iA2F57B18C9E7ECB7
GO

Mass spectrometryi

Molecular mass is 73967±2 Da from positions 49 - 675. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719486 mRNA. Translation: CAG31145.1.
RefSeqiNP_001006147.1. NM_001006147.1.
UniGeneiGga.8183.

Genome annotation databases

GeneIDi416183.
KEGGigga:416183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719486 mRNA. Translation: CAG31145.1.
RefSeqiNP_001006147.1. NM_001006147.1.
UniGeneiGga.8183.

3D structure databases

ProteinModelPortaliQ5ZM98.
SMRiQ5ZM98. Positions 57-582.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi677728. 1 interaction.
STRINGi9031.ENSGALP00000003717.

Proteomic databases

PaxDbiQ5ZM98.
PRIDEiQ5ZM98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi416183.
KEGGigga:416183.

Organism-specific databases

CTDi3313.

Phylogenomic databases

eggNOGiKOG0102. Eukaryota.
COG0443. LUCA.
HOGENOMiHOG000228135.
HOVERGENiHBG051845.
InParanoidiQ5ZM98.
KOiK04043.
PhylomeDBiQ5ZM98.

Miscellaneous databases

PROiQ5ZM98.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CBImported.
    Tissue: Bursa of FabriciusImported.
  2. "Proteomic analysis of the Gallus gallus embryo at stage-29 of development."
    Agudo D., Gomez-Esquer F., Diaz-Gil G., Martinez-Arribas F., Delcan J., Schneider J., Palomar M.A., Linares R.
    Proteomics 5:4946-4957(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, MASS SPECTROMETRY.
    Tissue: Embryo1 Publication.

Entry informationi

Entry nameiGRP75_CHICK
AccessioniPrimary (citable) accession number: Q5ZM98
Secondary accession number(s): P84163
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 23, 2004
Last modified: July 6, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.