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Protein

cAMP-dependent protein kinase type I-alpha regulatory subunit

Gene

PRKAR1A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei203cAMP 1By similarity1
Binding sitei212cAMP 1By similarity1
Binding sitei327cAMP 2By similarity1
Binding sitei336cAMP 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi138 – 255cAMP 1Add BLAST118
Nucleotide bindingi256 – 382cAMP 2Add BLAST127

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandcAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-163615 PKA activation
R-GGA-164378 PKA activation in glucagon signalling
R-GGA-180024 DARPP-32 events
R-GGA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-GGA-5610787 Hedgehog 'off' state
R-GGA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase type I-alpha regulatory subunit
Gene namesi
Name:PRKAR1A
ORF Names:RCJMB04_2n5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002934832 – 382cAMP-dependent protein kinase type I-alpha regulatory subunitAdd BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Disulfide bondi18Interchain (with C-39)By similarity
Disulfide bondi39Interchain (with C-18)By similarity

Post-translational modificationi

The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain but is not phosphorylated. The physiological significance of phosphorylations by other kinases is unclear (By similarity).By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ5ZM91
PRIDEiQ5ZM91

Expressioni

Gene expression databases

BgeeiENSGALG00000004237

Interactioni

Subunit structurei

The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006731

Structurei

3D structure databases

ProteinModelPortaliQ5ZM91
SMRiQ5ZM91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 136Dimerization and phosphorylationSequence analysisAdd BLAST135

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi97 – 101Pseudophosphorylation motif5

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1113 Eukaryota
COG0664 LUCA
GeneTreeiENSGT00530000062947
HOGENOMiHOG000196669
HOVERGENiHBG002025
InParanoidiQ5ZM91
KOiK04739
OMAiVQLCTVR
OrthoDBiEOG091G0F1K
PhylomeDBiQ5ZM91

Family and domain databases

CDDicd00038 CAP_ED, 2 hits
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR012198 cAMP_dep_PK_reg_su
IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
IPR018490 cNMP-bd-like
IPR018488 cNMP-bd_CS
IPR000595 cNMP-bd_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 2 hits
PF02197 RIIa, 1 hit
PIRSFiPIRSF000548 PK_regulatory, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 2 hits
SM00394 RIIa, 1 hit
SUPFAMiSSF51206 SSF51206, 2 hits
PROSITEiView protein in PROSITE
PS00888 CNMP_BINDING_1, 2 hits
PS00889 CNMP_BINDING_2, 2 hits
PS50042 CNMP_BINDING_3, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZM91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSSSSSSE EERSLRECEL YVQKHNIQQL LKDCIVQLCT VRPDRPMGFL
60 70 80 90 100
REYFERLEKE ETKQLLNQQK SGSRSDSRED EISPPPPMNP VVKGRRRRGA
110 120 130 140 150
ISAEVYTEED AASYVRKVIP KDYKTMAALA KAIEKNVLFA HLDDNERSDI
160 170 180 190 200
FDAMFPVTYI AGETVIQQGD EGDNFYVVDQ GEMDVYVNNE WATSVGEGGS
210 220 230 240 250
FGELALIYGT PRAATVKAKT NVKLWGIDRD SYRRILMGST LRKRKMYEEF
260 270 280 290 300
LSKVSILESL DKWERLTVAD ALEPVQFEDG QKIVVQGEPG DEFFIILEGT
310 320 330 340 350
AAVLQRRSEN EEFVEVGRLA PSDYFGEIAL LMNRPRAATV VARGLLKCVK
360 370 380
LDRPRFERVL GPCSDILKRN IQQYNSFVSL SV
Length:382
Mass (Da):43,350
Last modified:November 23, 2004 - v1
Checksum:iB7F778C55FC866D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719493 mRNA Translation: CAG31152.1
RefSeqiNP_001007846.1, NM_001007845.1
XP_015135378.1, XM_015279892.1
XP_015135379.1, XM_015279893.1
XP_015135380.1, XM_015279894.1
UniGeneiGga.4713

Genome annotation databases

EnsembliENSGALT00000034558; ENSGALP00000033915; ENSGALG00000004237
GeneIDi417438
KEGGigga:417438

Similar proteinsi

Entry informationi

Entry nameiKAP0_CHICK
AccessioniPrimary (citable) accession number: Q5ZM91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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