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Protein

Mitochondrial Rho GTPase 1

Gene

RHOT1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188GTP 1Sequence analysis
Nucleotide bindingi57 – 615GTP 1Sequence analysis
Nucleotide bindingi118 – 1214GTP 1Sequence analysis
Calcium bindingi197 – 208121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi317 – 328122PROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi426 – 4338GTP 2Sequence analysis
Nucleotide bindingi464 – 4685GTP 2Sequence analysis
Nucleotide bindingi528 – 5314GTP 2Sequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, GTP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial Rho GTPase 1 (EC:3.6.5.-)
Short name:
MIRO-1
Alternative name(s):
Ras homolog gene family member T1
Gene namesi
Name:RHOT1
ORF Names:RCJMB04_2p2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 593593Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei594 – 61623Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini617 – 6193CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Mitochondrial Rho GTPase 1PRO_0000239315Add
BLAST

Proteomic databases

PaxDbiQ5ZM73.
PRIDEiQ5ZM73.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005362.

Structurei

3D structure databases

ProteinModelPortaliQ5ZM73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 168168Miro 1Add
BLAST
Domaini184 – 21936EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini304 – 33936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini413 – 562150Miro 2Add
BLAST

Sequence similaritiesi

Belongs to the mitochondrial Rho GTPase family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 2 Miro domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1707. Eukaryota.
ENOG410XRHW. LUCA.
HOGENOMiHOG000215553.
HOVERGENiHBG079778.
InParanoidiQ5ZM73.
KOiK07870.
PhylomeDBiQ5ZM73.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO_dom.
IPR021181. Mt_Rho_GTPase.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF00071. Ras. 2 hits.
[Graphical view]
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZM73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKDVRILLV GEPRVGKTSL IMSLVSEEFP EEVPPRAEEI TIPADVTPER
60 70 80 90 100
VPTHIVDYSE AEQNDEQLYH EISQANVICI VYAVNNKNSI DKVTSRWIPL
110 120 130 140 150
INERTDKDSR LPLILVGNKS DLVEYSSMET ILPIMNQYTE IETCVECSAK
160 170 180 190 200
NLKNRSELFY YAQKAVLHPT GPLYCPEEKE MKPACIKALT RIFRISDQDN
210 220 230 240 250
DGTLNDAELN FFQRICFNTP LAPQALEDVK NVVRKNVSDG VADNGLTLKG
260 270 280 290 300
FLFLHTLFIQ RGRHETTWTV LRRFGYDDDL ELTPEYLFPL LKIPPDCTTE
310 320 330 340 350
LNHHAYLFLQ SIFDKHDLDR DCALSPDELK DLFKVFPYMP WGPDVNNTVC
360 370 380 390 400
TNGKGGWITY QGFLSQWTLT TYLDVQRCLE YLGYLGYSIL AEQESQASAI
410 420 430 440 450
TVTRDKKIDL QKKQTQRNVF RCNVVGMKGC GKSGVLQALL GRNLMRQRQI
460 470 480 490 500
RAEHKSYYAI NTVYVYGQEK YLLLHDVSDS EFLTDAETIC DVVCLVYDVS
510 520 530 540 550
NPKSFEYCVR IFKQHFMDSR IPCLVVAAKS DLHEVRQEYS ISPAEFCKKH
560 570 580 590 600
KMPPPQAFTC NTVDMPSKDI FVKLTTMAMY PHVTQADLKS STFWLRASFG
610
ATVFAFLGFA MYKALIKQR
Length:619
Mass (Da):70,894
Last modified:November 23, 2004 - v1
Checksum:i455212030C3632F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719511 mRNA. Translation: CAG31170.1.
RefSeqiNP_001006208.1. NM_001006208.1.
UniGeneiGga.28799.

Genome annotation databases

GeneIDi417410.
KEGGigga:417410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719511 mRNA. Translation: CAG31170.1.
RefSeqiNP_001006208.1. NM_001006208.1.
UniGeneiGga.28799.

3D structure databases

ProteinModelPortaliQ5ZM73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005362.

Proteomic databases

PaxDbiQ5ZM73.
PRIDEiQ5ZM73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi417410.
KEGGigga:417410.

Organism-specific databases

CTDi55288.

Phylogenomic databases

eggNOGiKOG1707. Eukaryota.
ENOG410XRHW. LUCA.
HOGENOMiHOG000215553.
HOVERGENiHBG079778.
InParanoidiQ5ZM73.
KOiK07870.
PhylomeDBiQ5ZM73.

Miscellaneous databases

NextBioi20820710.
PROiQ5ZM73.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO_dom.
IPR021181. Mt_Rho_GTPase.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF00071. Ras. 2 hits.
[Graphical view]
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiMIRO1_CHICK
AccessioniPrimary (citable) accession number: Q5ZM73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 23, 2004
Last modified: December 9, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.