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Protein

Serine/threonine-protein phosphatase

Gene

PPP2CA

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-GGA-1295596 Spry regulation of FGF signaling
R-GGA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-GGA-180024 DARPP-32 events
R-GGA-195253 Degradation of beta-catenin by the destruction complex
R-GGA-196299 Beta-catenin phosphorylation cascade
R-GGA-198753 ERK/MAPK targets
R-GGA-202670 ERKs are inactivated
R-GGA-2467813 Separation of Sister Chromatids
R-GGA-2500257 Resolution of Sister Chromatid Cohesion
R-GGA-2995383 Initiation of Nuclear Envelope Reformation
R-GGA-389513 CTLA4 inhibitory signaling
R-GGA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-GGA-5663220 RHO GTPases Activate Formins
R-GGA-5673000 RAF activation
R-GGA-5675221 Negative regulation of MAPK pathway
R-GGA-6804757 Regulation of TP53 Degradation
R-GGA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-GGA-68877 Mitotic Prometaphase
R-GGA-69231 Cyclin D associated events in G1
R-GGA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-GGA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
Gene namesi
Name:PPP2CAImported
ORF Names:RCJMB04_3c21Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSGALG00000006462

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010423

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 119SER_THR_PHOSPHATASEInterPro annotation6

Sequence similaritiesi

Belongs to the PPP phosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0371 Eukaryota
COG0639 LUCA
GeneTreeiENSGT00550000074618
HOGENOMiHOG000172696
HOVERGENiHBG000216
KOiK04382
OMAiNKIFCPH
OrthoDBiEOG091G0B6S
TreeFamiTF105559

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZM47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKVFTKEL DQWVEQLNEC KQLSEGQVKS LCEKAKEILT KESNVQEVRC
60 70 80 90 100
PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL
110 120 130 140 150
VALKVRYRER ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF
160 170 180 190 200
DYLPLTALVD GQIFCLHGGL SPSIDTLDHI RALDRLQEVP HEGPMCDLLW
210 220 230 240 250
SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA HQLVMEGYNW
260 270 280 290 300
CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV

TRRTPDYFL
Length:309
Mass (Da):35,564
Last modified:November 23, 2004 - v1
Checksum:i089461BB8C461E49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000380 Genomic DNA No translation available.
AJ719537 mRNA Translation: CAG31196.1
RefSeqiNP_001006152.1, NM_001006152.1
UniGeneiGga.8891

Genome annotation databases

EnsembliENSGALT00000010437; ENSGALP00000010423; ENSGALG00000006462
GeneIDi416318
KEGGigga:416318

Similar proteinsi

Entry informationi

Entry nameiQ5ZM47_CHICK
AccessioniPrimary (citable) accession number: Q5ZM47
Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health