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Protein

Serine/threonine-protein phosphatase

Gene

PPP2CA

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-113501. Inhibition of replication initiation of damaged DNA by RB1/E2F1.
R-GGA-1295596. Spry regulation of FGF signaling.
R-GGA-141444. Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
R-GGA-180024. DARPP-32 events.
R-GGA-195253. Degradation of beta-catenin by the destruction complex.
R-GGA-196299. Beta-catenin phosphorylation cascade.
R-GGA-198753. ERK/MAPK targets.
R-GGA-202670. ERKs are inactivated.
R-GGA-2467813. Separation of Sister Chromatids.
R-GGA-2500257. Resolution of Sister Chromatid Cohesion.
R-GGA-2995383. Initiation of Nuclear Envelope Reformation.
R-GGA-389513. CTLA4 inhibitory signaling.
R-GGA-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.
R-GGA-5663220. RHO GTPases Activate Formins.
R-GGA-5673000. RAF activation.
R-GGA-5675221. Negative regulation of MAPK pathway.
R-GGA-6804757. Regulation of TP53 Degradation.
R-GGA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-GGA-68877. Mitotic Prometaphase.
R-GGA-69231. Cyclin D associated events in G1.
R-GGA-69273. Cyclin A/B1/B2 associated events during G2/M transition.
R-GGA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
Gene namesi
Name:PPP2CAImported
ORF Names:RCJMB04_3c21Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSGALG00000006462.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010423.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 119SER_THR_PHOSPHATASEInterPro annotation6

Sequence similaritiesi

Belongs to the PPP phosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0371. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00550000074618.
HOGENOMiHOG000172696.
HOVERGENiHBG000216.
OMAiEGYNWGQ.
OrthoDBiEOG091G0B6S.
TreeFamiTF105559.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZM47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKVFTKEL DQWVEQLNEC KQLSEGQVKS LCEKAKEILT KESNVQEVRC
60 70 80 90 100
PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL
110 120 130 140 150
VALKVRYRER ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF
160 170 180 190 200
DYLPLTALVD GQIFCLHGGL SPSIDTLDHI RALDRLQEVP HEGPMCDLLW
210 220 230 240 250
SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA HQLVMEGYNW
260 270 280 290 300
CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV

TRRTPDYFL
Length:309
Mass (Da):35,564
Last modified:November 23, 2004 - v1
Checksum:i089461BB8C461E49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000380 Genomic DNA. No translation available.
AJ719537 mRNA. Translation: CAG31196.1.
RefSeqiNP_001006152.1. NM_001006152.1.
UniGeneiGga.8891.

Genome annotation databases

EnsembliENSGALT00000010437; ENSGALP00000010423; ENSGALG00000006462.
GeneIDi416318.

Similar proteinsi

Entry informationi

Entry nameiQ5ZM47_CHICK
AccessioniPrimary (citable) accession number: Q5ZM47
Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: November 22, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported