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Protein

Ubiquitin carboxyl-terminal hydrolase 48

Gene

USP48

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981NucleophilePROSITE-ProRule annotation
Active sitei351 – 3511Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.068.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 48 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 48
Ubiquitin thioesterase 48
Ubiquitin-specific-processing protease 48
Gene namesi
Name:USP48
ORF Names:RCJMB04_3d5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10331033Ubiquitin carboxyl-terminal hydrolase 48PRO_0000249526Add
BLAST

Proteomic databases

PaxDbiQ5ZM45.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022836.

Structurei

3D structure databases

ProteinModelPortaliQ5ZM45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 419331USPAdd
BLAST
Domaini457 – 55296DUSP 1PROSITE-ProRule annotationAdd
BLAST
Domaini567 – 690124DUSP 2PROSITE-ProRule annotationAdd
BLAST
Domaini710 – 823114DUSP 3PROSITE-ProRule annotationAdd
BLAST
Domaini931 – 100777Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 3 DUSP domains.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000231639.
HOVERGENiHBG080368.
InParanoidiQ5ZM45.
KOiK11858.
PhylomeDBiQ5ZM45.

Family and domain databases

Gene3Di3.30.2230.10. 1 hit.
InterProiIPR006615. Pept_C19_DUSP.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00695. DUSP. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZM45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRLQLEKA AWRWTETVPP EAVTQEHIEA AYRVGLEPCQ RGTCRRNCRG
60 70 80 90 100
NPNCLVGIGE HVWLGEIDEN SFHNIDDPNC ERRKKNAFVG LTNLGATCYV
110 120 130 140 150
NTFLQMWFLN LELRQALYLC SSNEHAAGES IPKDKDYEPQ TICEHLQYLF
160 170 180 190 200
ALLQNSKRRY IDPSGFVKAL GLDTGQQQDA QEFSKLFMSL LEDTLSKQKN
210 220 230 240 250
PDVRNIVQKQ FCGEYAYVTV CNQCGRESKL VSKFYELELN IQGHKQLTDC
260 270 280 290 300
ITEFLKEEKL EGDNRYFCET CQSKQNATRK IRLLSLPCTL NLQLMRFVFD
310 320 330 340 350
RQTGHKKKLN TYIGFSELLD MEPFMEQKNG VYVYELSAVL IHRGVSAYSG
360 370 380 390 400
HYIAHVKDPQ TGEWYKFNDE DIEKMEGKKL QLGIEEDLAE PSKSQTRKPK
410 420 430 440 450
CGKGTHCSRN AYMLVYRLQT REKSLTVEVP AFLQELVERD NCKFEEWCNE
460 470 480 490 500
MAEMRKQSVA RGKIKHEEVK ELYQRLPAEA GSPYDFISLE WLQKWLDEST
510 520 530 540 550
PPKPIDNTAC LCSHGKLHPD KICIMKRISE YVADFFYRRY GGGPRLNVKA
560 570 580 590 600
LCKDCVVERC RILRLKNQLN EDYKTVTNLL KITVKGSEGF WVGKASLRSW
610 620 630 640 650
RQLALEQLNE QDEDAEHSNG KLNGNAPNKD EVNEEKREEE EELNFNEDIV
660 670 680 690 700
CPHGDLCISE NERRVVSKEA WKKLKQYFPK APEFPSNKEC CSQCKILERE
710 720 730 740 750
GEENEALHKM MASEQKTSLQ NLFHDKCRPC LGSWPQETDE LYIVSQFFVE
760 770 780 790 800
EWRKFVRRPT RCSPVSSLGN SALLCPHGGL MFTYASMTKE DSKLIALIWP
810 820 830 840 850
SEWERIQKLF VVDHVIKITR TRAAGEPESA LYSSEPQLCP ECRGGLLCQQ
860 870 880 890 900
QRDLREYTQA TIYIHKVVDN KKVMKDAAPE LNVSSSEAEE EREENKPEGE
910 920 930 940 950
QDPDFNQSNG GAKRQKLSHQ SYISYQKQGI RRSTRHRKVR GEKALLVSAN
960 970 980 990 1000
QTLKELKIQI MHAFSVAPFD QNLLIDGKIL SDDTATLGSL GIIPESVILL
1010 1020 1030
KADEPIADYA AMDDVMQVCM PEEGFKGTGL LGH
Length:1,033
Mass (Da):118,691
Last modified:November 23, 2004 - v1
Checksum:i55E1960AAFB983C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719539 mRNA. Translation: CAG31198.1.
RefSeqiNP_001073211.1. NM_001079743.1.
UniGeneiGga.20232.

Genome annotation databases

GeneIDi769457.
KEGGigga:769457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719539 mRNA. Translation: CAG31198.1.
RefSeqiNP_001073211.1. NM_001079743.1.
UniGeneiGga.20232.

3D structure databases

ProteinModelPortaliQ5ZM45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022836.

Protein family/group databases

MEROPSiC19.068.

Proteomic databases

PaxDbiQ5ZM45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi769457.
KEGGigga:769457.

Organism-specific databases

CTDi84196.

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000231639.
HOVERGENiHBG080368.
InParanoidiQ5ZM45.
KOiK11858.
PhylomeDBiQ5ZM45.

Miscellaneous databases

NextBioi20919686.
PROiQ5ZM45.

Family and domain databases

Gene3Di3.30.2230.10. 1 hit.
InterProiIPR006615. Pept_C19_DUSP.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00695. DUSP. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiUBP48_CHICK
AccessioniPrimary (citable) accession number: Q5ZM45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 23, 2004
Last modified: February 4, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.