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Protein

Ubiquitin carboxyl-terminal hydrolase 48

Gene

USP48

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei98NucleophilePROSITE-ProRule annotation1
Active sitei351Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC19.068

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 48 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 48
Ubiquitin thioesterase 48
Ubiquitin-specific-processing protease 48
Gene namesi
Name:USP48
ORF Names:RCJMB04_3d5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002495261 – 1033Ubiquitin carboxyl-terminal hydrolase 48Add BLAST1033

Proteomic databases

PaxDbiQ5ZM45
PRIDEiQ5ZM45

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022836

Structurei

3D structure databases

ProteinModelPortaliQ5ZM45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 419USPAdd BLAST331
Domaini457 – 552DUSP 1PROSITE-ProRule annotationAdd BLAST96
Domaini567 – 690DUSP 2PROSITE-ProRule annotationAdd BLAST124
Domaini710 – 823DUSP 3PROSITE-ProRule annotationAdd BLAST114
Domaini931 – 1007Ubiquitin-likePROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1863 Eukaryota
COG5077 LUCA
HOGENOMiHOG000231639
HOVERGENiHBG080368
InParanoidiQ5ZM45
KOiK11858
PhylomeDBiQ5ZM45

Family and domain databases

CDDicd02668 Peptidase_C19L, 1 hit
InterProiView protein in InterPro
IPR035927 DUSP-like_sf
IPR006615 Pept_C19_DUSP
IPR001394 Peptidase_C19_UCH
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
IPR033841 USP48
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
PF00443 UCH, 1 hit
SMARTiView protein in SMART
SM00695 DUSP, 1 hit
SUPFAMiSSF143791 SSF143791, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51283 DUSP, 3 hits
PS50053 UBIQUITIN_2, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZM45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRLQLEKA AWRWTETVPP EAVTQEHIEA AYRVGLEPCQ RGTCRRNCRG
60 70 80 90 100
NPNCLVGIGE HVWLGEIDEN SFHNIDDPNC ERRKKNAFVG LTNLGATCYV
110 120 130 140 150
NTFLQMWFLN LELRQALYLC SSNEHAAGES IPKDKDYEPQ TICEHLQYLF
160 170 180 190 200
ALLQNSKRRY IDPSGFVKAL GLDTGQQQDA QEFSKLFMSL LEDTLSKQKN
210 220 230 240 250
PDVRNIVQKQ FCGEYAYVTV CNQCGRESKL VSKFYELELN IQGHKQLTDC
260 270 280 290 300
ITEFLKEEKL EGDNRYFCET CQSKQNATRK IRLLSLPCTL NLQLMRFVFD
310 320 330 340 350
RQTGHKKKLN TYIGFSELLD MEPFMEQKNG VYVYELSAVL IHRGVSAYSG
360 370 380 390 400
HYIAHVKDPQ TGEWYKFNDE DIEKMEGKKL QLGIEEDLAE PSKSQTRKPK
410 420 430 440 450
CGKGTHCSRN AYMLVYRLQT REKSLTVEVP AFLQELVERD NCKFEEWCNE
460 470 480 490 500
MAEMRKQSVA RGKIKHEEVK ELYQRLPAEA GSPYDFISLE WLQKWLDEST
510 520 530 540 550
PPKPIDNTAC LCSHGKLHPD KICIMKRISE YVADFFYRRY GGGPRLNVKA
560 570 580 590 600
LCKDCVVERC RILRLKNQLN EDYKTVTNLL KITVKGSEGF WVGKASLRSW
610 620 630 640 650
RQLALEQLNE QDEDAEHSNG KLNGNAPNKD EVNEEKREEE EELNFNEDIV
660 670 680 690 700
CPHGDLCISE NERRVVSKEA WKKLKQYFPK APEFPSNKEC CSQCKILERE
710 720 730 740 750
GEENEALHKM MASEQKTSLQ NLFHDKCRPC LGSWPQETDE LYIVSQFFVE
760 770 780 790 800
EWRKFVRRPT RCSPVSSLGN SALLCPHGGL MFTYASMTKE DSKLIALIWP
810 820 830 840 850
SEWERIQKLF VVDHVIKITR TRAAGEPESA LYSSEPQLCP ECRGGLLCQQ
860 870 880 890 900
QRDLREYTQA TIYIHKVVDN KKVMKDAAPE LNVSSSEAEE EREENKPEGE
910 920 930 940 950
QDPDFNQSNG GAKRQKLSHQ SYISYQKQGI RRSTRHRKVR GEKALLVSAN
960 970 980 990 1000
QTLKELKIQI MHAFSVAPFD QNLLIDGKIL SDDTATLGSL GIIPESVILL
1010 1020 1030
KADEPIADYA AMDDVMQVCM PEEGFKGTGL LGH
Length:1,033
Mass (Da):118,691
Last modified:November 23, 2004 - v1
Checksum:i55E1960AAFB983C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719539 mRNA Translation: CAG31198.1
RefSeqiNP_001073211.1, NM_001079743.1
UniGeneiGga.20232

Genome annotation databases

GeneIDi769457
KEGGigga:769457

Similar proteinsi

Entry informationi

Entry nameiUBP48_CHICK
AccessioniPrimary (citable) accession number: Q5ZM45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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