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Q5ZM45

- UBP48_CHICK

UniProt

Q5ZM45 - UBP48_CHICK

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Protein
Ubiquitin carboxyl-terminal hydrolase 48
Gene
USP48, RCJMB04_3d5
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981Nucleophile By similarity
Active sitei351 – 3511Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.068.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 48 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 48
Ubiquitin thioesterase 48
Ubiquitin-specific-processing protease 48
Gene namesi
Name:USP48
ORF Names:RCJMB04_3d5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10331033Ubiquitin carboxyl-terminal hydrolase 48
PRO_0000249526Add
BLAST

Proteomic databases

PaxDbiQ5ZM45.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022836.

Structurei

3D structure databases

ProteinModelPortaliQ5ZM45.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 419331USP
Add
BLAST
Domaini457 – 55296DUSP 1
Add
BLAST
Domaini567 – 690124DUSP 2
Add
BLAST
Domaini710 – 823114DUSP 3
Add
BLAST
Domaini931 – 100777Ubiquitin-like
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 3 DUSP domains.
Contains 1 USP domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000231639.
HOVERGENiHBG080368.
InParanoidiQ5ZM45.
KOiK11858.
PhylomeDBiQ5ZM45.

Family and domain databases

Gene3Di3.30.2230.10. 1 hit.
InterProiIPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00695. DUSP. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZM45-1 [UniParc]FASTAAdd to Basket

« Hide

MAPRLQLEKA AWRWTETVPP EAVTQEHIEA AYRVGLEPCQ RGTCRRNCRG     50
NPNCLVGIGE HVWLGEIDEN SFHNIDDPNC ERRKKNAFVG LTNLGATCYV 100
NTFLQMWFLN LELRQALYLC SSNEHAAGES IPKDKDYEPQ TICEHLQYLF 150
ALLQNSKRRY IDPSGFVKAL GLDTGQQQDA QEFSKLFMSL LEDTLSKQKN 200
PDVRNIVQKQ FCGEYAYVTV CNQCGRESKL VSKFYELELN IQGHKQLTDC 250
ITEFLKEEKL EGDNRYFCET CQSKQNATRK IRLLSLPCTL NLQLMRFVFD 300
RQTGHKKKLN TYIGFSELLD MEPFMEQKNG VYVYELSAVL IHRGVSAYSG 350
HYIAHVKDPQ TGEWYKFNDE DIEKMEGKKL QLGIEEDLAE PSKSQTRKPK 400
CGKGTHCSRN AYMLVYRLQT REKSLTVEVP AFLQELVERD NCKFEEWCNE 450
MAEMRKQSVA RGKIKHEEVK ELYQRLPAEA GSPYDFISLE WLQKWLDEST 500
PPKPIDNTAC LCSHGKLHPD KICIMKRISE YVADFFYRRY GGGPRLNVKA 550
LCKDCVVERC RILRLKNQLN EDYKTVTNLL KITVKGSEGF WVGKASLRSW 600
RQLALEQLNE QDEDAEHSNG KLNGNAPNKD EVNEEKREEE EELNFNEDIV 650
CPHGDLCISE NERRVVSKEA WKKLKQYFPK APEFPSNKEC CSQCKILERE 700
GEENEALHKM MASEQKTSLQ NLFHDKCRPC LGSWPQETDE LYIVSQFFVE 750
EWRKFVRRPT RCSPVSSLGN SALLCPHGGL MFTYASMTKE DSKLIALIWP 800
SEWERIQKLF VVDHVIKITR TRAAGEPESA LYSSEPQLCP ECRGGLLCQQ 850
QRDLREYTQA TIYIHKVVDN KKVMKDAAPE LNVSSSEAEE EREENKPEGE 900
QDPDFNQSNG GAKRQKLSHQ SYISYQKQGI RRSTRHRKVR GEKALLVSAN 950
QTLKELKIQI MHAFSVAPFD QNLLIDGKIL SDDTATLGSL GIIPESVILL 1000
KADEPIADYA AMDDVMQVCM PEEGFKGTGL LGH 1033
Length:1,033
Mass (Da):118,691
Last modified:November 23, 2004 - v1
Checksum:i55E1960AAFB983C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ719539 mRNA. Translation: CAG31198.1.
RefSeqiNP_001073211.1. NM_001079743.1.
UniGeneiGga.20232.

Genome annotation databases

GeneIDi769457.
KEGGigga:769457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ719539 mRNA. Translation: CAG31198.1 .
RefSeqi NP_001073211.1. NM_001079743.1.
UniGenei Gga.20232.

3D structure databases

ProteinModelPortali Q5ZM45.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000022836.

Protein family/group databases

MEROPSi C19.068.

Proteomic databases

PaxDbi Q5ZM45.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 769457.
KEGGi gga:769457.

Organism-specific databases

CTDi 84196.

Phylogenomic databases

eggNOGi COG5077.
HOGENOMi HOG000231639.
HOVERGENi HBG080368.
InParanoidi Q5ZM45.
KOi K11858.
PhylomeDBi Q5ZM45.

Miscellaneous databases

NextBioi 20919686.
PROi Q5ZM45.

Family and domain databases

Gene3Di 3.30.2230.10. 1 hit.
InterProi IPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00240. ubiquitin. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view ]
SMARTi SM00695. DUSP. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF143791. SSF143791. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiUBP48_CHICK
AccessioniPrimary (citable) accession number: Q5ZM45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi