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Q5ZM45

- UBP48_CHICK

UniProt

Q5ZM45 - UBP48_CHICK

Protein

Ubiquitin carboxyl-terminal hydrolase 48

Gene

USP48

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei98 – 981NucleophilePROSITE-ProRule annotation
    Active sitei351 – 3511Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.068.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 48 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 48
    Ubiquitin thioesterase 48
    Ubiquitin-specific-processing protease 48
    Gene namesi
    Name:USP48
    ORF Names:RCJMB04_3d5
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10331033Ubiquitin carboxyl-terminal hydrolase 48PRO_0000249526Add
    BLAST

    Proteomic databases

    PaxDbiQ5ZM45.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000022836.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZM45.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini89 – 419331USPAdd
    BLAST
    Domaini457 – 55296DUSP 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini567 – 690124DUSP 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini710 – 823114DUSP 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini931 – 100777Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 3 DUSP domains.PROSITE-ProRule annotation
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5077.
    HOGENOMiHOG000231639.
    HOVERGENiHBG080368.
    InParanoidiQ5ZM45.
    KOiK11858.
    PhylomeDBiQ5ZM45.

    Family and domain databases

    Gene3Di3.30.2230.10. 1 hit.
    InterProiIPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00240. ubiquitin. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00695. DUSP. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF143791. SSF143791. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS51283. DUSP. 3 hits.
    PS50053. UBIQUITIN_2. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5ZM45-1 [UniParc]FASTAAdd to Basket

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    MAPRLQLEKA AWRWTETVPP EAVTQEHIEA AYRVGLEPCQ RGTCRRNCRG     50
    NPNCLVGIGE HVWLGEIDEN SFHNIDDPNC ERRKKNAFVG LTNLGATCYV 100
    NTFLQMWFLN LELRQALYLC SSNEHAAGES IPKDKDYEPQ TICEHLQYLF 150
    ALLQNSKRRY IDPSGFVKAL GLDTGQQQDA QEFSKLFMSL LEDTLSKQKN 200
    PDVRNIVQKQ FCGEYAYVTV CNQCGRESKL VSKFYELELN IQGHKQLTDC 250
    ITEFLKEEKL EGDNRYFCET CQSKQNATRK IRLLSLPCTL NLQLMRFVFD 300
    RQTGHKKKLN TYIGFSELLD MEPFMEQKNG VYVYELSAVL IHRGVSAYSG 350
    HYIAHVKDPQ TGEWYKFNDE DIEKMEGKKL QLGIEEDLAE PSKSQTRKPK 400
    CGKGTHCSRN AYMLVYRLQT REKSLTVEVP AFLQELVERD NCKFEEWCNE 450
    MAEMRKQSVA RGKIKHEEVK ELYQRLPAEA GSPYDFISLE WLQKWLDEST 500
    PPKPIDNTAC LCSHGKLHPD KICIMKRISE YVADFFYRRY GGGPRLNVKA 550
    LCKDCVVERC RILRLKNQLN EDYKTVTNLL KITVKGSEGF WVGKASLRSW 600
    RQLALEQLNE QDEDAEHSNG KLNGNAPNKD EVNEEKREEE EELNFNEDIV 650
    CPHGDLCISE NERRVVSKEA WKKLKQYFPK APEFPSNKEC CSQCKILERE 700
    GEENEALHKM MASEQKTSLQ NLFHDKCRPC LGSWPQETDE LYIVSQFFVE 750
    EWRKFVRRPT RCSPVSSLGN SALLCPHGGL MFTYASMTKE DSKLIALIWP 800
    SEWERIQKLF VVDHVIKITR TRAAGEPESA LYSSEPQLCP ECRGGLLCQQ 850
    QRDLREYTQA TIYIHKVVDN KKVMKDAAPE LNVSSSEAEE EREENKPEGE 900
    QDPDFNQSNG GAKRQKLSHQ SYISYQKQGI RRSTRHRKVR GEKALLVSAN 950
    QTLKELKIQI MHAFSVAPFD QNLLIDGKIL SDDTATLGSL GIIPESVILL 1000
    KADEPIADYA AMDDVMQVCM PEEGFKGTGL LGH 1033
    Length:1,033
    Mass (Da):118,691
    Last modified:November 23, 2004 - v1
    Checksum:i55E1960AAFB983C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ719539 mRNA. Translation: CAG31198.1.
    RefSeqiNP_001073211.1. NM_001079743.1.
    UniGeneiGga.20232.

    Genome annotation databases

    GeneIDi769457.
    KEGGigga:769457.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ719539 mRNA. Translation: CAG31198.1 .
    RefSeqi NP_001073211.1. NM_001079743.1.
    UniGenei Gga.20232.

    3D structure databases

    ProteinModelPortali Q5ZM45.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000022836.

    Protein family/group databases

    MEROPSi C19.068.

    Proteomic databases

    PaxDbi Q5ZM45.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 769457.
    KEGGi gga:769457.

    Organism-specific databases

    CTDi 84196.

    Phylogenomic databases

    eggNOGi COG5077.
    HOGENOMi HOG000231639.
    HOVERGENi HBG080368.
    InParanoidi Q5ZM45.
    KOi K11858.
    PhylomeDBi Q5ZM45.

    Miscellaneous databases

    NextBioi 20919686.
    PROi Q5ZM45.

    Family and domain databases

    Gene3Di 3.30.2230.10. 1 hit.
    InterProi IPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00240. ubiquitin. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00695. DUSP. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF143791. SSF143791. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS51283. DUSP. 3 hits.
    PS50053. UBIQUITIN_2. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiUBP48_CHICK
    AccessioniPrimary (citable) accession number: Q5ZM45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3