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Q5ZM45 (UBP48_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 48

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 48
Ubiquitin thioesterase 48
Ubiquitin-specific-processing protease 48
Gene names
Name:USP48
ORF Names:RCJMB04_3d5
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length1033 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 3 DUSP domains.

Contains 1 ubiquitin-like domain.

Contains 1 USP domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCytoplasm
Nucleus
   DomainRepeat
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionubiquitin-specific protease activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10331033Ubiquitin carboxyl-terminal hydrolase 48
PRO_0000249526

Regions

Domain89 – 419331USP
Domain457 – 55296DUSP 1
Domain567 – 690124DUSP 2
Domain710 – 823114DUSP 3
Domain931 – 100777Ubiquitin-like

Sites

Active site981Nucleophile By similarity
Active site3511Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZM45 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 55E1960AAFB983C2

FASTA1,033118,691
        10         20         30         40         50         60 
MAPRLQLEKA AWRWTETVPP EAVTQEHIEA AYRVGLEPCQ RGTCRRNCRG NPNCLVGIGE 

        70         80         90        100        110        120 
HVWLGEIDEN SFHNIDDPNC ERRKKNAFVG LTNLGATCYV NTFLQMWFLN LELRQALYLC 

       130        140        150        160        170        180 
SSNEHAAGES IPKDKDYEPQ TICEHLQYLF ALLQNSKRRY IDPSGFVKAL GLDTGQQQDA 

       190        200        210        220        230        240 
QEFSKLFMSL LEDTLSKQKN PDVRNIVQKQ FCGEYAYVTV CNQCGRESKL VSKFYELELN 

       250        260        270        280        290        300 
IQGHKQLTDC ITEFLKEEKL EGDNRYFCET CQSKQNATRK IRLLSLPCTL NLQLMRFVFD 

       310        320        330        340        350        360 
RQTGHKKKLN TYIGFSELLD MEPFMEQKNG VYVYELSAVL IHRGVSAYSG HYIAHVKDPQ 

       370        380        390        400        410        420 
TGEWYKFNDE DIEKMEGKKL QLGIEEDLAE PSKSQTRKPK CGKGTHCSRN AYMLVYRLQT 

       430        440        450        460        470        480 
REKSLTVEVP AFLQELVERD NCKFEEWCNE MAEMRKQSVA RGKIKHEEVK ELYQRLPAEA 

       490        500        510        520        530        540 
GSPYDFISLE WLQKWLDEST PPKPIDNTAC LCSHGKLHPD KICIMKRISE YVADFFYRRY 

       550        560        570        580        590        600 
GGGPRLNVKA LCKDCVVERC RILRLKNQLN EDYKTVTNLL KITVKGSEGF WVGKASLRSW 

       610        620        630        640        650        660 
RQLALEQLNE QDEDAEHSNG KLNGNAPNKD EVNEEKREEE EELNFNEDIV CPHGDLCISE 

       670        680        690        700        710        720 
NERRVVSKEA WKKLKQYFPK APEFPSNKEC CSQCKILERE GEENEALHKM MASEQKTSLQ 

       730        740        750        760        770        780 
NLFHDKCRPC LGSWPQETDE LYIVSQFFVE EWRKFVRRPT RCSPVSSLGN SALLCPHGGL 

       790        800        810        820        830        840 
MFTYASMTKE DSKLIALIWP SEWERIQKLF VVDHVIKITR TRAAGEPESA LYSSEPQLCP 

       850        860        870        880        890        900 
ECRGGLLCQQ QRDLREYTQA TIYIHKVVDN KKVMKDAAPE LNVSSSEAEE EREENKPEGE 

       910        920        930        940        950        960 
QDPDFNQSNG GAKRQKLSHQ SYISYQKQGI RRSTRHRKVR GEKALLVSAN QTLKELKIQI 

       970        980        990       1000       1010       1020 
MHAFSVAPFD QNLLIDGKIL SDDTATLGSL GIIPESVILL KADEPIADYA AMDDVMQVCM 

      1030 
PEEGFKGTGL LGH 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ719539 mRNA. Translation: CAG31198.1.
RefSeqNP_001073211.1. NM_001079743.1.
UniGeneGga.20232.

3D structure databases

ProteinModelPortalQ5ZM45.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000022836.

Protein family/group databases

MEROPSC19.068.

Proteomic databases

PaxDbQ5ZM45.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID769457.
KEGGgga:769457.

Organism-specific databases

CTD84196.

Phylogenomic databases

eggNOGCOG5077.
HOGENOMHOG000231639.
HOVERGENHBG080368.
InParanoidQ5ZM45.
KOK11858.
PhylomeDBQ5ZM45.

Family and domain databases

Gene3D3.30.2230.10. 1 hit.
InterProIPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00240. ubiquitin. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTSM00695. DUSP. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMSSF143791. SSF143791. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEPS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20919686.
PROQ5ZM45.

Entry information

Entry nameUBP48_CHICK
AccessionPrimary (citable) accession number: Q5ZM45
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries