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Q5ZM35

- TWF2_CHICK

UniProt

Q5ZM35 - TWF2_CHICK

Protein

Twinfilin-2

Gene

TWF2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin By similarity.By similarity

    GO - Biological processi

    1. negative regulation of actin filament polymerization Source: InterPro

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Twinfilin-2
    Gene namesi
    Name:TWF2
    ORF Names:RCJMB04_3e19
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Cytoplasmperinuclear region By similarity
    Note: Perinuclear and G-actin-rich cortical actin structure sublocalization.By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Twinfilin-2PRO_0000233139Add
    BLAST

    Proteomic databases

    PaxDbiQ5ZM35.

    Interactioni

    Subunit structurei

    Interacts with G-actin; ADP-actin form and capping protein (CP).By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000006327.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZM35.
    SMRiQ5ZM35. Positions 6-137, 161-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 139136ADF-H 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini177 – 313137ADF-H 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ADF-H domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000168296.
    HOVERGENiHBG000848.
    KOiK08870.
    PhylomeDBiQ5ZM35.

    Family and domain databases

    Gene3Di3.40.20.10. 2 hits.
    InterProiIPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR028458. Twinfilin.
    [Graphical view]
    PANTHERiPTHR13759. PTHR13759. 1 hit.
    PfamiPF00241. Cofilin_ADF. 2 hits.
    [Graphical view]
    SMARTiSM00102. ADF. 2 hits.
    [Graphical view]
    PROSITEiPS51263. ADF_H. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5ZM35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHQTGIHAT TELRDFFAKA RNGSVRLIKV IIEEEQLVLG AHKELARRWD    50
    VDYDAFVLPL LDEQQPCYVL YRLDSQNAQG YEWLFISWSP DNSPVRLKML 100
    YAATRATVKK EFGGGHIKDE MFGTVKEDVS LSGYQKHVSS CSAPAPLTAA 150
    EQELQQIRIN EVKTEISVES KHQTLQGLAF PLQLDAQQAI QTLKQKKINY 200
    IQLKLDLERE TIDLVHTSPT DISDLPKRIP QDSARYHFFL YKHSHEGDYL 250
    ESVVFIYSMP GYKCSIKERM LYSSCKSRLL DTVEQEFCLE IAKKIEIDDG 300
    AELTAEFLYD EVHPKQHAFK QAFAKPKGPV GKRGQKRLIK GPGENGEDS 349
    Length:349
    Mass (Da):39,835
    Last modified:November 23, 2004 - v1
    Checksum:i8F4EFDBA0453BD97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ719549 mRNA. Translation: CAG31208.1.
    RefSeqiNP_001025760.1. NM_001030589.1.
    UniGeneiGga.7292.

    Genome annotation databases

    GeneIDi415940.
    KEGGigga:415940.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Molecular embrace - Issue 73 of August 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ719549 mRNA. Translation: CAG31208.1 .
    RefSeqi NP_001025760.1. NM_001030589.1.
    UniGenei Gga.7292.

    3D structure databases

    ProteinModelPortali Q5ZM35.
    SMRi Q5ZM35. Positions 6-137, 161-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000006327.

    Proteomic databases

    PaxDbi Q5ZM35.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 415940.
    KEGGi gga:415940.

    Organism-specific databases

    CTDi 11344.

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000168296.
    HOVERGENi HBG000848.
    KOi K08870.
    PhylomeDBi Q5ZM35.

    Miscellaneous databases

    NextBioi 20819466.

    Family and domain databases

    Gene3Di 3.40.20.10. 2 hits.
    InterProi IPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR028458. Twinfilin.
    [Graphical view ]
    PANTHERi PTHR13759. PTHR13759. 1 hit.
    Pfami PF00241. Cofilin_ADF. 2 hits.
    [Graphical view ]
    SMARTi SM00102. ADF. 2 hits.
    [Graphical view ]
    PROSITEi PS51263. ADF_H. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.
    2. "Twinfilin 2 regulates actin filament lengths in cochlear stereocilia."
      Peng A.W., Belyantseva I.A., Hsu P.D., Friedman T.B., Heller S.
      J. Neurosci. 29:15083-15088(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cochlea.

    Entry informationi

    Entry nameiTWF2_CHICK
    AccessioniPrimary (citable) accession number: Q5ZM35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3