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Protein

Twinfilin-2

Gene

TWF2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin (By similarity).By similarity

GO - Biological processi

  1. negative regulation of actin filament polymerization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Twinfilin-2
Gene namesi
Name:TWF2
ORF Names:RCJMB04_3e19
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cytoplasmperinuclear region By similarity
Note: Perinuclear and G-actin-rich cortical actin structure sublocalization.By similarity

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB-SubCell
  2. perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Twinfilin-2PRO_0000233139Add
BLAST

Proteomic databases

PaxDbiQ5ZM35.

Interactioni

Subunit structurei

Interacts with G-actin; ADP-actin form and capping protein (CP).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006327.

Structurei

3D structure databases

ProteinModelPortaliQ5ZM35.
SMRiQ5ZM35. Positions 6-137, 161-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 139136ADF-H 1PROSITE-ProRule annotationAdd
BLAST
Domaini177 – 313137ADF-H 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ADF-H domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000168296.
HOVERGENiHBG000848.
InParanoidiQ5ZM35.
KOiK08870.
PhylomeDBiQ5ZM35.

Family and domain databases

Gene3Di3.40.20.10. 2 hits.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028458. Twinfilin.
[Graphical view]
PANTHERiPTHR13759. PTHR13759. 1 hit.
PfamiPF00241. Cofilin_ADF. 2 hits.
[Graphical view]
SMARTiSM00102. ADF. 2 hits.
[Graphical view]
PROSITEiPS51263. ADF_H. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZM35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHQTGIHAT TELRDFFAKA RNGSVRLIKV IIEEEQLVLG AHKELARRWD
60 70 80 90 100
VDYDAFVLPL LDEQQPCYVL YRLDSQNAQG YEWLFISWSP DNSPVRLKML
110 120 130 140 150
YAATRATVKK EFGGGHIKDE MFGTVKEDVS LSGYQKHVSS CSAPAPLTAA
160 170 180 190 200
EQELQQIRIN EVKTEISVES KHQTLQGLAF PLQLDAQQAI QTLKQKKINY
210 220 230 240 250
IQLKLDLERE TIDLVHTSPT DISDLPKRIP QDSARYHFFL YKHSHEGDYL
260 270 280 290 300
ESVVFIYSMP GYKCSIKERM LYSSCKSRLL DTVEQEFCLE IAKKIEIDDG
310 320 330 340
AELTAEFLYD EVHPKQHAFK QAFAKPKGPV GKRGQKRLIK GPGENGEDS
Length:349
Mass (Da):39,835
Last modified:November 23, 2004 - v1
Checksum:i8F4EFDBA0453BD97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719549 mRNA. Translation: CAG31208.1.
RefSeqiNP_001025760.1. NM_001030589.1.
UniGeneiGga.7292.

Genome annotation databases

GeneIDi415940.
KEGGigga:415940.

Cross-referencesi

Web resourcesi

Protein Spotlight

Molecular embrace - Issue 73 of August 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719549 mRNA. Translation: CAG31208.1.
RefSeqiNP_001025760.1. NM_001030589.1.
UniGeneiGga.7292.

3D structure databases

ProteinModelPortaliQ5ZM35.
SMRiQ5ZM35. Positions 6-137, 161-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006327.

Proteomic databases

PaxDbiQ5ZM35.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi415940.
KEGGigga:415940.

Organism-specific databases

CTDi11344.

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000168296.
HOVERGENiHBG000848.
InParanoidiQ5ZM35.
KOiK08870.
PhylomeDBiQ5ZM35.

Miscellaneous databases

NextBioi20819466.

Family and domain databases

Gene3Di3.40.20.10. 2 hits.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028458. Twinfilin.
[Graphical view]
PANTHERiPTHR13759. PTHR13759. 1 hit.
PfamiPF00241. Cofilin_ADF. 2 hits.
[Graphical view]
SMARTiSM00102. ADF. 2 hits.
[Graphical view]
PROSITEiPS51263. ADF_H. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.
  2. "Twinfilin 2 regulates actin filament lengths in cochlear stereocilia."
    Peng A.W., Belyantseva I.A., Hsu P.D., Friedman T.B., Heller S.
    J. Neurosci. 29:15083-15088(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cochlea.

Entry informationi

Entry nameiTWF2_CHICK
AccessioniPrimary (citable) accession number: Q5ZM35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 23, 2004
Last modified: February 4, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.