Q5ZM35 (TWF2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Twinfilin-2

Gene names

Name:	TWF2
ORF Names:	RCJMB04_3e19

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin By similarity.
Subunit structure	Interacts with G-actin; ADP-actin form and capping protein (CP) By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity. Cytoplasm › perinuclear region By similarity. Note: Perinuclear and G-actin-rich cortical actin structure sublocalization By similarity.
Sequence similarities	Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. Contains 2 ADF-H domains.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Domain	Repeat
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Twinfilin-2		PRO_0000233139
Regions
	Domain	4 – 139	136	ADF-H 1
	Domain	177 – 313	137	ADF-H 2

Sequences

	Sequence		Length	Mass (Da)
	Q5ZM35 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 8F4EFDBA0453BD97	FASTA	349	39,835
	10 20 30 40 50 60 MTHQTGIHAT TELRDFFAKA RNGSVRLIKV IIEEEQLVLG AHKELARRWD VDYDAFVLPL 70 80 90 100 110 120 LDEQQPCYVL YRLDSQNAQG YEWLFISWSP DNSPVRLKML YAATRATVKK EFGGGHIKDE 130 140 150 160 170 180 MFGTVKEDVS LSGYQKHVSS CSAPAPLTAA EQELQQIRIN EVKTEISVES KHQTLQGLAF 190 200 210 220 230 240 PLQLDAQQAI QTLKQKKINY IQLKLDLERE TIDLVHTSPT DISDLPKRIP QDSARYHFFL 250 260 270 280 290 300 YKHSHEGDYL ESVVFIYSMP GYKCSIKERM LYSSCKSRLL DTVEQEFCLE IAKKIEIDDG 310 320 330 340 AELTAEFLYD EVHPKQHAFK QAFAKPKGPV GKRGQKRLIK GPGENGEDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.
[2]	"Twinfilin 2 regulates actin filament lengths in cochlear stereocilia." Peng A.W., Belyantseva I.A., Hsu P.D., Friedman T.B., Heller S. J. Neurosci. 29:15083-15088(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY. Tissue: Cochlea.

Web resources

Protein Spotlight

Molecular embrace - Issue 73 of August 2006

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ719549 mRNA. Translation: CAG31208.1.
IPI	IPI00590073.
RefSeq	NP_001025760.1. NM_001030589.1.
UniGene	Gga.7292.
3D structure databases
ProteinModelPortal	Q5ZM35.
SMR	Q5ZM35. Positions 6-137, 161-313.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000006327.
Proteomic databases
PaxDb	Q5ZM35.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	415940.
KEGG	gga:415940.
Organism-specific databases
CTD	11344.
Phylogenomic databases
eggNOG	COG2319.
HOGENOM	HOG000168296.
HOVERGEN	HBG000848.
KO	K08870.
Family and domain databases
InterPro	IPR002108. Actin-bd_cofilin/tropomyosin. [Graphical view]
Pfam	PF00241. Cofilin_ADF. 2 hits. [Graphical view]
SMART	SM00102. ADF. 2 hits. [Graphical view]
PROSITE	PS51263. ADF_H. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	20819466.

Entry information

Entry name

TWF2_CHICK

Accession

Primary (citable) accession number: Q5ZM35

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	November 23, 2004
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program