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Q5ZM35 (TWF2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Twinfilin-2
Gene names
Name:TWF2
ORF Names:RCJMB04_3e19
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin By similarity.

Subunit structure

Interacts with G-actin; ADP-actin form and capping protein (CP) By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity. Cytoplasmperinuclear region By similarity. Note: Perinuclear and G-actin-rich cortical actin structure sublocalization By similarity.

Sequence similarities

Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.

Contains 2 ADF-H domains.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   DomainRepeat
   LigandActin-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of actin filament polymerization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Twinfilin-2
PRO_0000233139

Regions

Domain4 – 139136ADF-H 1
Domain177 – 313137ADF-H 2

Sequences

Sequence LengthMass (Da)Tools
Q5ZM35 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 8F4EFDBA0453BD97

FASTA34939,835
        10         20         30         40         50         60 
MTHQTGIHAT TELRDFFAKA RNGSVRLIKV IIEEEQLVLG AHKELARRWD VDYDAFVLPL 

        70         80         90        100        110        120 
LDEQQPCYVL YRLDSQNAQG YEWLFISWSP DNSPVRLKML YAATRATVKK EFGGGHIKDE 

       130        140        150        160        170        180 
MFGTVKEDVS LSGYQKHVSS CSAPAPLTAA EQELQQIRIN EVKTEISVES KHQTLQGLAF 

       190        200        210        220        230        240 
PLQLDAQQAI QTLKQKKINY IQLKLDLERE TIDLVHTSPT DISDLPKRIP QDSARYHFFL 

       250        260        270        280        290        300 
YKHSHEGDYL ESVVFIYSMP GYKCSIKERM LYSSCKSRLL DTVEQEFCLE IAKKIEIDDG 

       310        320        330        340 
AELTAEFLYD EVHPKQHAFK QAFAKPKGPV GKRGQKRLIK GPGENGEDS 

« Hide

References

« Hide 'large scale' references
[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.
[2]"Twinfilin 2 regulates actin filament lengths in cochlear stereocilia."
Peng A.W., Belyantseva I.A., Hsu P.D., Friedman T.B., Heller S.
J. Neurosci. 29:15083-15088(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Cochlea.

Web resources

Protein Spotlight

Molecular embrace - Issue 73 of August 2006

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ719549 mRNA. Translation: CAG31208.1.
RefSeqNP_001025760.1. NM_001030589.1.
UniGeneGga.7292.

3D structure databases

ProteinModelPortalQ5ZM35.
SMRQ5ZM35. Positions 6-137, 161-313.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000006327.

Proteomic databases

PaxDbQ5ZM35.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID415940.
KEGGgga:415940.

Organism-specific databases

CTD11344.

Phylogenomic databases

eggNOGCOG2319.
HOGENOMHOG000168296.
HOVERGENHBG000848.
KOK08870.
PhylomeDBQ5ZM35.

Family and domain databases

Gene3D3.40.20.10. 2 hits.
InterProIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028458. Twinfilin.
[Graphical view]
PANTHERPTHR13759. PTHR13759. 1 hit.
PfamPF00241. Cofilin_ADF. 2 hits.
[Graphical view]
SMARTSM00102. ADF. 2 hits.
[Graphical view]
PROSITEPS51263. ADF_H. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20819466.

Entry information

Entry nameTWF2_CHICK
AccessionPrimary (citable) accession number: Q5ZM35
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries