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Protein

Regulation of nuclear pre-mRNA domain-containing protein 1A

Gene

RPRD1A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Regulation of nuclear pre-mRNA domain-containing protein 1A
Alternative name(s):
Cyclin-dependent kinase inhibitor 2B-related protein
p15INK4B-related protein
Gene namesi
Name:RPRD1A
Synonyms:P15RS
ORF Names:RCJMB04_3f10
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113471 – 268Regulation of nuclear pre-mRNA domain-containing protein 1AAdd BLAST268

Proteomic databases

PaxDbiQ5ZM30.

Interactioni

Subunit structurei

May form a heterodimer with RPRD1B. Associates with the RNA polymerase II subunit POLR2A (via CTD phosphorylated at 'Ser-2' and 'Ser-7' of the heptad repeats).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021401.

Structurei

3D structure databases

ProteinModelPortaliQ5ZM30.
SMRiQ5ZM30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 133CIDPROSITE-ProRule annotationAdd BLAST133

Sequence similaritiesi

Belongs to the UPF0400 (RTT103) family.Curated

Phylogenomic databases

eggNOGiKOG2669. Eukaryota.
ENOG410XRAP. LUCA.
HOGENOMiHOG000007456.
HOVERGENiHBG051177.
InParanoidiQ5ZM30.
PhylomeDBiQ5ZM30.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiView protein in InterPro
IPR006569. CID_dom.
IPR032337. CREPT.
IPR008942. ENTH_VHS.
IPR006903. RNA_pol_II-bd.
PfamiView protein in Pfam
PF16566. CREPT. 1 hit.
PF04818. CTD_bind. 1 hit.
SMARTiView protein in SMART
SM00582. RPR. 1 hit.
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiView protein in PROSITE
PS51391. CID. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZM30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAFSEAALE RKLSELSNSQ QSVQTLSLWL IHHRKHSALI VSVWERELRK
60 70 80 90 100
AKPNRKLTFL YLANDVIQNS KRKGPEFTKD FAPVIVEAFK HVSSESDESC
110 120 130 140 150
KKHPGRVLSI WEERSVYEND VLEQLRQALY GDRKVRKRTY EQIKVDENNC
160 170 180 190 200
SPRSSPTDPP QTMDLIRALQ ELENAASGDA AVHQRIASLP IEVQDVSLLD
210 220 230 240 250
RITDKESGEQ LSKMVDDACM LLADYNGRLA AEIDDRKQLT RMLSDFLRCQ
260
KEFLAEKEHK LEVRIVLF
Length:268
Mass (Da):30,836
Last modified:November 23, 2004 - v1
Checksum:i9E066A613F247AB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719554 mRNA. Translation: CAG31213.1.
RefSeqiNP_001026176.1. NM_001031005.2.
UniGeneiGga.12933.

Genome annotation databases

GeneIDi420953.
KEGGigga:420953.

Similar proteinsi

Entry informationi

Entry nameiRPR1A_CHICK
AccessioniPrimary (citable) accession number: Q5ZM30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 23, 2004
Last modified: February 15, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries