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Protein

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

Gene

SLC9A3R1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. May enhance Wnt signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Short name:
NHERF-1
Alternative name(s):
Ezrin-radixin-moesin-binding phosphoprotein 50
Short name:
EBP50
Regulatory cofactor of Na(+)/H(+) exchanger
Sodium-hydrogen exchanger regulatory factor 1
Solute carrier family 9 isoform A3 regulatory factor 1
Gene namesi
Name:SLC9A3R1
Synonyms:NHERF, NHERF1
ORF Names:RCJMB04_3g21
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Na(+)/H(+) exchange regulatory cofactor NHE-RF1PRO_0000301266Add
BLAST

Proteomic databases

PaxDbiQ5ZM14.
PRIDEiQ5ZM14.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012367.

Structurei

3D structure databases

ProteinModelPortaliQ5ZM14.
SMRiQ5ZM14. Positions 11-97, 131-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 9381PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini135 – 21581PDZ 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG4110362. LUCA.
HOGENOMiHOG000089940.
HOVERGENiHBG052616.
InParanoidiQ5ZM14.
KOiK13365.
PhylomeDBiQ5ZM14.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR015098. EBP50_C-term.
IPR031199. NHERF-1.
IPR017300. NHERF-1/NHERF-2.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR14191:SF7. PTHR14191:SF7. 1 hit.
PfamiPF09007. EBP50_C. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
PIRSFiPIRSF037866. EBP50. 1 hit.
ProDomiPD283022. EBP50_C-term. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZM14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAPPGPAA PRLCCMEKGP DGYGFHLHGE KGKPGQYIRL VEAGSPAERS
60 70 80 90 100
GLRAGDRLLE VDGTNVERES HQQVVERIRA AAGAVRLLVV QPQPEEQPPK
110 120 130 140 150
THSDPDGEAQ REPPAAETPA AERSGPEERE LRPRLCRIKK GPNGYGFNLH
160 170 180 190 200
SEKSRPGQYV RAVDPDSPAE AAGLRAQDRI VEVNGTSVEG KQHADVVAAI
210 220 230 240 250
KAGGDETKLL VVGVLADEFF KKCRVVPSEA HLAGPLPEPM ANGDVEKENG
260 270 280 290 300
GEPRLNSVSE RPPSPALATS PEGSETHSEP DTQEGDKRSS APSSLLDLDI
310 320 330
PLAVAKERAH QKRTSKRAPQ MDWSKKNELF SNL
Length:333
Mass (Da):35,805
Last modified:November 23, 2004 - v1
Checksum:i352D02280D6AEE65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719570 mRNA. Translation: CAG31229.1.
RefSeqiNP_001006424.1. NM_001006424.1.
UniGeneiGga.1222.

Genome annotation databases

GeneIDi422108.
KEGGigga:422108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719570 mRNA. Translation: CAG31229.1.
RefSeqiNP_001006424.1. NM_001006424.1.
UniGeneiGga.1222.

3D structure databases

ProteinModelPortaliQ5ZM14.
SMRiQ5ZM14. Positions 11-97, 131-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012367.

Proteomic databases

PaxDbiQ5ZM14.
PRIDEiQ5ZM14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi422108.
KEGGigga:422108.

Organism-specific databases

CTDi9368.

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG4110362. LUCA.
HOGENOMiHOG000089940.
HOVERGENiHBG052616.
InParanoidiQ5ZM14.
KOiK13365.
PhylomeDBiQ5ZM14.

Miscellaneous databases

PROiQ5ZM14.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR015098. EBP50_C-term.
IPR031199. NHERF-1.
IPR017300. NHERF-1/NHERF-2.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR14191:SF7. PTHR14191:SF7. 1 hit.
PfamiPF09007. EBP50_C. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
PIRSFiPIRSF037866. EBP50. 1 hit.
ProDomiPD283022. EBP50_C-term. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiNHRF1_CHICK
AccessioniPrimary (citable) accession number: Q5ZM14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.