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Protein

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

Gene

SLC9A3R1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. May enhance Wnt signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Short name:
NHERF-1
Alternative name(s):
Ezrin-radixin-moesin-binding phosphoprotein 50
Short name:
EBP50
Regulatory cofactor of Na(+)/H(+) exchanger
Sodium-hydrogen exchanger regulatory factor 1
Solute carrier family 9 isoform A3 regulatory factor 1
Gene namesi
Name:SLC9A3R1
Synonyms:NHERF, NHERF1
ORF Names:RCJMB04_3g21
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003012661 – 333Na(+)/H(+) exchange regulatory cofactor NHE-RF1Add BLAST333

Proteomic databases

PaxDbiQ5ZM14.
PRIDEiQ5ZM14.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012367.

Structurei

3D structure databases

ProteinModelPortaliQ5ZM14.
SMRiQ5ZM14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 93PDZ 1PROSITE-ProRule annotationAdd BLAST81
Domaini135 – 215PDZ 2PROSITE-ProRule annotationAdd BLAST81

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG4110362. LUCA.
HOGENOMiHOG000089940.
HOVERGENiHBG052616.
InParanoidiQ5ZM14.
KOiK13365.
PhylomeDBiQ5ZM14.

Family and domain databases

InterProiView protein in InterPro
IPR015098. EBP50_C-term.
IPR031199. NHERF-1.
IPR017300. NHERF-1/NHERF-2.
IPR001478. PDZ.
PANTHERiPTHR14191:SF14. PTHR14191:SF14. 1 hit.
PfamiView protein in Pfam
PF09007. EBP50_C. 1 hit.
PF00595. PDZ. 2 hits.
PIRSFiPIRSF037866. EBP50. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD283022. EBP50_C-term. 1 hit.
SMARTiView protein in SMART
SM00228. PDZ. 2 hits.
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiView protein in PROSITE
PS50106. PDZ. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5ZM14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAPPGPAA PRLCCMEKGP DGYGFHLHGE KGKPGQYIRL VEAGSPAERS
60 70 80 90 100
GLRAGDRLLE VDGTNVERES HQQVVERIRA AAGAVRLLVV QPQPEEQPPK
110 120 130 140 150
THSDPDGEAQ REPPAAETPA AERSGPEERE LRPRLCRIKK GPNGYGFNLH
160 170 180 190 200
SEKSRPGQYV RAVDPDSPAE AAGLRAQDRI VEVNGTSVEG KQHADVVAAI
210 220 230 240 250
KAGGDETKLL VVGVLADEFF KKCRVVPSEA HLAGPLPEPM ANGDVEKENG
260 270 280 290 300
GEPRLNSVSE RPPSPALATS PEGSETHSEP DTQEGDKRSS APSSLLDLDI
310 320 330
PLAVAKERAH QKRTSKRAPQ MDWSKKNELF SNL
Length:333
Mass (Da):35,805
Last modified:November 23, 2004 - v1
Checksum:i352D02280D6AEE65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719570 mRNA. Translation: CAG31229.1.
RefSeqiNP_001006424.1. NM_001006424.1.
UniGeneiGga.1222.

Genome annotation databases

GeneIDi422108.
KEGGigga:422108.

Similar proteinsi

Entry informationi

Entry nameiNHRF1_CHICK
AccessioniPrimary (citable) accession number: Q5ZM14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 23, 2004
Last modified: August 30, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome