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Protein

Arginine--tRNA ligase, cytoplasmic

Gene

RARS

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.By similarity

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei212L-arginineBy similarity1
Binding sitei385L-arginineBy similarity1
Binding sitei389L-arginineBy similarity1
Binding sitei413L-arginineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase, cytoplasmic (EC:6.1.1.19By similarity)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:RARS
ORF Names:RCJMB04_3h11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002507291 – 661Arginine--tRNA ligase, cytoplasmicAdd BLAST661

Proteomic databases

PaxDbiQ5ZM11.
PRIDEiQ5ZM11.

Interactioni

Subunit structurei

Monomer; also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002862.

Structurei

3D structure databases

ProteinModelPortaliQ5ZM11.
SMRiQ5ZM11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 72Could be involved in the assembly of the multisynthetase complexBy similarityAdd BLAST72
Regioni201 – 203L-arginine bindingBy similarity3
Regioni530 – 544Interaction with tRNABy similarityAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi202 – 213"HIGH" regionAdd BLAST12

Domaini

The alpha-helical N-terminus (residues 1-72) mediates interaction with AIMP1 and thereby contributes to the assembly of the multisynthetase complex.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1195. Eukaryota.
COG0018. LUCA.
HOGENOMiHOG000247212.
HOVERGENiHBG029238.
InParanoidiQ5ZM11.
KOiK01887.
PhylomeDBiQ5ZM11.

Family and domain databases

CDDicd00671. ArgRS_core. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR035684. ArgRS_core.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZM11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARVAEAAA RLARQENEIK SLTAEIEHLK NFGCLGISPS LEGLRDENAK
60 70 80 90 100
LKYRLNFLQK SLQEEQSKTV KSMININSRL QEIFGAAIQA AYPELENPPL
110 120 130 140 150
VVTPSQQPKF GDYQCNSAMG ITQILLKTKE QKVSPREIAE KITKHIPANE
160 170 180 190 200
CIEKVEIAGP GFINVHLRKD FVSKQLSSLL VNGVQPPAIG KRKKVILDFS
210 220 230 240 250
SPNIAKEMHV GHLRSTIIGE SMCRLFEFAG YDVLRLNHLG DWGTQFGMLI
260 270 280 290 300
AHLQDRFPDY LTVSPPIGDL QAFYKESKRR FDTEEEFKKR AYQCVVLLQS
310 320 330 340 350
KDPDFIKAWE LICDVSRKEF QKIYNCLDVT LTERGESFYQ DMMKDIVKEF
360 370 380 390 400
EDKGFVQVDD GRKIVFVPGF SVPLTIMKSD GGYTYDTSDL AALRHRLLEE
410 420 430 440 450
KGDILIYVVD SGQSVHLQTV FAAGQMIGWY DPKVTRITHA AFGVVLGEDK
460 470 480 490 500
KKFKTRSGDT VRLMDLLEEG LKRAMDKLKD KERDKVLTPE ELKAAQMSVA
510 520 530 540 550
FGCIKYADLS HNRLNDYVFS FDKMLDDRGN TAAYLLYAFT RIRAIARLAN
560 570 580 590 600
IDEGMLRKAA REEVIVLDHE KEWKLGKCIL RFPEILQKIL DDLLLHTLCD
610 620 630 640 650
YLYELATTFT EFYDNCYCVE KDRQSGQIMK VNTWRLLLCE ATATIMAKGF
660
DILGIKPVER M
Length:661
Mass (Da):75,418
Last modified:November 23, 2004 - v1
Checksum:i92D61B5BB5BC030B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719573 mRNA. Translation: CAG31232.1.
RefSeqiNP_001025778.1. NM_001030607.1.
UniGeneiGga.22550.

Genome annotation databases

GeneIDi416168.
KEGGigga:416168.

Similar proteinsi

Entry informationi

Entry nameiSYRC_CHICK
AccessioniPrimary (citable) accession number: Q5ZM11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: September 27, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families