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Q5ZM11

- SYRC_CHICK

UniProt

Q5ZM11 - SYRC_CHICK

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Protein
Arginine--tRNA ligase, cytoplasmic
Gene
RARS, RCJMB04_3h11
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis By similarity.UniRule annotation

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. arginine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase, cytoplasmic (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:RARS
ORF Names:RCJMB04_3h11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 661661Arginine--tRNA ligase, cytoplasmicUniRule annotation
PRO_0000250729Add
BLAST

Proteomic databases

PaxDbiQ5ZM11.
PRIDEiQ5ZM11.

Interactioni

Subunit structurei

Monomer; also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro By similarity.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002862.

Structurei

3D structure databases

ProteinModelPortaliQ5ZM11.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7272Could be involved in the assembly of the multisynthetase complex By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi202 – 21312"HIGH" regionUniRule annotation
Add
BLAST

Domaini

The N-terminus (AA 1-72) has two regions predicted to be alpha-helical that might be involved in the multisynthetase complex assembly By similarity.UniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247212.
HOVERGENiHBG029238.
InParanoidiQ5ZM11.
KOiK01887.
PhylomeDBiQ5ZM11.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZM11-1 [UniParc]FASTAAdd to Basket

« Hide

MEARVAEAAA RLARQENEIK SLTAEIEHLK NFGCLGISPS LEGLRDENAK    50
LKYRLNFLQK SLQEEQSKTV KSMININSRL QEIFGAAIQA AYPELENPPL 100
VVTPSQQPKF GDYQCNSAMG ITQILLKTKE QKVSPREIAE KITKHIPANE 150
CIEKVEIAGP GFINVHLRKD FVSKQLSSLL VNGVQPPAIG KRKKVILDFS 200
SPNIAKEMHV GHLRSTIIGE SMCRLFEFAG YDVLRLNHLG DWGTQFGMLI 250
AHLQDRFPDY LTVSPPIGDL QAFYKESKRR FDTEEEFKKR AYQCVVLLQS 300
KDPDFIKAWE LICDVSRKEF QKIYNCLDVT LTERGESFYQ DMMKDIVKEF 350
EDKGFVQVDD GRKIVFVPGF SVPLTIMKSD GGYTYDTSDL AALRHRLLEE 400
KGDILIYVVD SGQSVHLQTV FAAGQMIGWY DPKVTRITHA AFGVVLGEDK 450
KKFKTRSGDT VRLMDLLEEG LKRAMDKLKD KERDKVLTPE ELKAAQMSVA 500
FGCIKYADLS HNRLNDYVFS FDKMLDDRGN TAAYLLYAFT RIRAIARLAN 550
IDEGMLRKAA REEVIVLDHE KEWKLGKCIL RFPEILQKIL DDLLLHTLCD 600
YLYELATTFT EFYDNCYCVE KDRQSGQIMK VNTWRLLLCE ATATIMAKGF 650
DILGIKPVER M 661
Length:661
Mass (Da):75,418
Last modified:November 23, 2004 - v1
Checksum:i92D61B5BB5BC030B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ719573 mRNA. Translation: CAG31232.1.
RefSeqiNP_001025778.1. NM_001030607.1.
UniGeneiGga.22550.

Genome annotation databases

GeneIDi416168.
KEGGigga:416168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ719573 mRNA. Translation: CAG31232.1 .
RefSeqi NP_001025778.1. NM_001030607.1.
UniGenei Gga.22550.

3D structure databases

ProteinModelPortali Q5ZM11.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000002862.

Proteomic databases

PaxDbi Q5ZM11.
PRIDEi Q5ZM11.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 416168.
KEGGi gga:416168.

Organism-specific databases

CTDi 5917.

Phylogenomic databases

eggNOGi COG0018.
HOGENOMi HOG000247212.
HOVERGENi HBG029238.
InParanoidi Q5ZM11.
KOi K01887.
PhylomeDBi Q5ZM11.

Miscellaneous databases

NextBioi 20819670.
PROi Q5ZM11.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiSYRC_CHICK
AccessioniPrimary (citable) accession number: Q5ZM11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi