Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5ZM11 (SYRC_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase, cytoplasmic

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:RARS
ORF Names:RCJMB04_3h11
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length661 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis By similarity. HAMAP-Rule MF_00123

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer; also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Domain

The N-terminus (AA 1-72) has two regions predicted to be alpha-helical that might be involved in the multisynthetase complex assembly By similarity. HAMAP-Rule MF_00123

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 661661Arginine--tRNA ligase, cytoplasmic HAMAP-Rule MF_00123
PRO_0000250729

Regions

Region1 – 7272Could be involved in the assembly of the multisynthetase complex By similarity
Motif202 – 21312"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q5ZM11 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 92D61B5BB5BC030B

FASTA66175,418
        10         20         30         40         50         60 
MEARVAEAAA RLARQENEIK SLTAEIEHLK NFGCLGISPS LEGLRDENAK LKYRLNFLQK 

        70         80         90        100        110        120 
SLQEEQSKTV KSMININSRL QEIFGAAIQA AYPELENPPL VVTPSQQPKF GDYQCNSAMG 

       130        140        150        160        170        180 
ITQILLKTKE QKVSPREIAE KITKHIPANE CIEKVEIAGP GFINVHLRKD FVSKQLSSLL 

       190        200        210        220        230        240 
VNGVQPPAIG KRKKVILDFS SPNIAKEMHV GHLRSTIIGE SMCRLFEFAG YDVLRLNHLG 

       250        260        270        280        290        300 
DWGTQFGMLI AHLQDRFPDY LTVSPPIGDL QAFYKESKRR FDTEEEFKKR AYQCVVLLQS 

       310        320        330        340        350        360 
KDPDFIKAWE LICDVSRKEF QKIYNCLDVT LTERGESFYQ DMMKDIVKEF EDKGFVQVDD 

       370        380        390        400        410        420 
GRKIVFVPGF SVPLTIMKSD GGYTYDTSDL AALRHRLLEE KGDILIYVVD SGQSVHLQTV 

       430        440        450        460        470        480 
FAAGQMIGWY DPKVTRITHA AFGVVLGEDK KKFKTRSGDT VRLMDLLEEG LKRAMDKLKD 

       490        500        510        520        530        540 
KERDKVLTPE ELKAAQMSVA FGCIKYADLS HNRLNDYVFS FDKMLDDRGN TAAYLLYAFT 

       550        560        570        580        590        600 
RIRAIARLAN IDEGMLRKAA REEVIVLDHE KEWKLGKCIL RFPEILQKIL DDLLLHTLCD 

       610        620        630        640        650        660 
YLYELATTFT EFYDNCYCVE KDRQSGQIMK VNTWRLLLCE ATATIMAKGF DILGIKPVER 


M 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ719573 mRNA. Translation: CAG31232.1.
RefSeqNP_001025778.1. NM_001030607.1.
UniGeneGga.22550.

3D structure databases

ProteinModelPortalQ5ZM11.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000002862.

Proteomic databases

PaxDbQ5ZM11.
PRIDEQ5ZM11.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID416168.
KEGGgga:416168.

Organism-specific databases

CTD5917.

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247212.
HOVERGENHBG029238.
InParanoidQ5ZM11.
KOK01887.
PhylomeDBQ5ZM11.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20819670.
PROQ5ZM11.

Entry information

Entry nameSYRC_CHICK
AccessionPrimary (citable) accession number: Q5ZM11
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries