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Protein

Eukaryotic translation initiation factor 2 subunit 1

Gene

EIF2S1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

ReactomeiR-GGA-381042 PERK regulates gene expression
R-GGA-72649 Translation initiation complex formation
R-GGA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-GGA-72702 Ribosomal scanning and start codon recognition
R-GGA-72731 Recycling of eIF2:GDP

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 2 subunit 1
Alternative name(s):
Eukaryotic translation initiation factor 2 subunit alpha
Short name:
eIF-2-alpha
Short name:
eIF-2A
Short name:
eIF-2alpha
Gene namesi
Name:EIF2S1
Synonyms:EIF2A
ORF Names:RCJMB04_4i21
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003312422 – 315Eukaryotic translation initiation factor 2 subunit 1Add BLAST314

Proteomic databases

PaxDbiQ5ZLX2
PRIDEiQ5ZLX2

Expressioni

Gene expression databases

BgeeiENSGALG00000009565

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain. Component of the EIF2 complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015560

Structurei

3D structure databases

ProteinModelPortaliQ5ZLX2
SMRiQ5ZLX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 88S1 motifPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Belongs to the eIF-2-alpha family.Curated

Phylogenomic databases

eggNOGiKOG2916 Eukaryota
COG1093 LUCA
GeneTreeiENSGT00390000007015
HOGENOMiHOG000199476
HOVERGENiHBG001910
InParanoidiQ5ZLX2
KOiK03237
OMAiKDVNEHQ
OrthoDBiEOG091G07NN
PhylomeDBiQ5ZLX2
TreeFamiTF101502

Family and domain databases

Gene3Di1.10.150.190, 1 hit
3.30.70.1130, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR022967 S1_dom
IPR003029 S1_domain
IPR024055 TIF2_asu_C
IPR024054 TIF2_asu_middle_sf
IPR011488 TIF_2_asu
PANTHERiPTHR10602 PTHR10602, 1 hit
PfamiView protein in Pfam
PF07541 EIF_2_alpha, 1 hit
PF00575 S1, 1 hit
SMARTiView protein in SMART
SM00316 S1, 1 hit
SUPFAMiSSF110993 SSF110993, 1 hit
SSF116742 SSF116742, 1 hit
SSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZLX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPALSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE
60 70 80 90 100
LSRRRIRSIN KLIRIGRNEC VVVIRVDKEK GYIDLSKRRV SPEEAIKCED
110 120 130 140 150
KFTKSKTVYS ILRHVAEVLE YTKDEQLESL FQRTAWVFDD KYKRPGYGAY
160 170 180 190 200
DAFKHAVSDP AILDSLDLTE EERRVLIDNI NRRLTPQAVK IRADIEVACY
210 220 230 240 250
GYEGIDAVKE ALRAGLNCST ENMPIKINLI APPRYVMTTT TLERTEGLSV
260 270 280 290 300
LNQAMAVIKE KIEEKRGVFN VQMEPKVVTD TDETELARQL ERLERENAEV
310
DGDDDAEEME AKTED
Length:315
Mass (Da):36,178
Last modified:April 29, 2008 - v2
Checksum:i7AD67C14FD92A491
GO

Sequence cautioni

The sequence CAG31271 differs from that shown. Reason: Erroneous termination at position 289. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289Missing in CAG31271 (PubMed:15642098).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BU385483 mRNA No translation available.
AJ719612 mRNA Translation: CAG31271.1 Sequence problems.
RefSeqiNP_001006477.1, NM_001006477.1
UniGeneiGga.21991

Genome annotation databases

EnsembliENSGALT00000015576; ENSGALP00000015560; ENSGALG00000009565
ENSGALT00000075355; ENSGALP00000047783; ENSGALG00000009565
GeneIDi423279
KEGGigga:423279

Similar proteinsi

Entry informationi

Entry nameiIF2A_CHICK
AccessioniPrimary (citable) accession number: Q5ZLX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

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