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Protein

Early growth response protein

Gene

RCJMB04_4l24

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.UniRule annotation

GO - Molecular functioni

  • DNA binding Source: AgBase
  • DNA binding transcription factor activity Source: AgBase
  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: AgBase

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response proteinUniRule annotation
Gene namesi
ORF Names:RCJMB04_4l24Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5ZLU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini310 – 339C2H2-typeInterPro annotationAdd BLAST30
Domaini340 – 367C2H2-typeInterPro annotationAdd BLAST28
Domaini368 – 395C2H2-typeInterPro annotationAdd BLAST28

Sequence similaritiesi

Belongs to the EGR C2H2-type zinc-finger protein family.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000036856
HOVERGENiHBG003909
KOiK09203

Family and domain databases

InterProiView protein in InterPro
IPR021849 EGR
IPR021839 EGR1_C
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF11914 DUF3432, 1 hit
PF11928 DUF3446, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q5ZLU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKAEMQL LPSLQISDPF GVFPHSPPAM DGHYPKLEEM MLLSGGGQQF
60 70 80 90 100
LAPSGAPESA GFGAAGEPSE QHFEHLAADT FPEISLNNEK TMPETSYPNQ
110 120 130 140 150
TTRLPPITYT GRFSLEPAPN GSNTLWPEPL FSLVSGLVSM ANAPPTSTPS
160 170 180 190 200
SSSPSSSQST PLSCSVQASE NSPIYSAAPT FPTSSSDIFP EPQTQPFPNP
210 220 230 240 250
SGVPIQYPPP AYPTAKTNFQ VPMIPDYLFP QQQSELNLIS ADQKPFSALE
260 270 280 290 300
TRAQQPSLTP LSTIKAFATQ TGSQELKTLN ANYQSQLIKP SRMRKYPNRP
310 320 330 340 350
SKTPPHERPY ACPVESCDRR FSRSDELTRH IRIHTGQKPF QCRICMRNFS
360 370 380 390 400
RSDHLTTHIR THTGEKPFAC DICGRKFARS DERKRHTKIH LRQKDKKVEK
410 420 430 440 450
AASVSATSSS VAAYSSSVAT SYSSSIATTY PSPVRTVYSS PASSSYPSPA
460 470 480 490 500
HTTFPSPSIA TTYSSGTATF QTQVATSFPS PGVTNNFSSQ VTSALSDMTS
510
TFSPRTIEIC
Length:510
Mass (Da):55,351
Last modified:November 23, 2004 - v1
Checksum:i90B21EC163D95E4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719635 mRNA Translation: CAG31294.1
RefSeqiNP_989467.2, NM_204136.2
UniGeneiGga.4922

Genome annotation databases

GeneIDi373931
KEGGigga:373931

Similar proteinsi

Entry informationi

Entry nameiQ5ZLU9_CHICK
AccessioniPrimary (citable) accession number: Q5ZLU9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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