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Protein

Early growth response protein

Gene

RCJMB04_4l24

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response proteinUniRule annotation
Gene namesi
ORF Names:RCJMB04_4l24Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ5ZLU9.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012417.

Structurei

3D structure databases

ProteinModelPortaliQ5ZLU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini310 – 339C2H2-typeInterPro annotationAdd BLAST30
Domaini340 – 367C2H2-typeInterPro annotationAdd BLAST28
Domaini368 – 395C2H2-typeInterPro annotationAdd BLAST28

Sequence similaritiesi

Belongs to the EGR C2H2-type zinc-finger protein family.UniRule annotation
Contains 3 C2H2-type zinc fingers.UniRule annotation

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000036856.
HOVERGENiHBG003909.
KOiK09203.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021839. DUF3432.
IPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11914. DUF3432. 1 hit.
PF11928. DUF3446. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZLU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKAEMQL LPSLQISDPF GVFPHSPPAM DGHYPKLEEM MLLSGGGQQF
60 70 80 90 100
LAPSGAPESA GFGAAGEPSE QHFEHLAADT FPEISLNNEK TMPETSYPNQ
110 120 130 140 150
TTRLPPITYT GRFSLEPAPN GSNTLWPEPL FSLVSGLVSM ANAPPTSTPS
160 170 180 190 200
SSSPSSSQST PLSCSVQASE NSPIYSAAPT FPTSSSDIFP EPQTQPFPNP
210 220 230 240 250
SGVPIQYPPP AYPTAKTNFQ VPMIPDYLFP QQQSELNLIS ADQKPFSALE
260 270 280 290 300
TRAQQPSLTP LSTIKAFATQ TGSQELKTLN ANYQSQLIKP SRMRKYPNRP
310 320 330 340 350
SKTPPHERPY ACPVESCDRR FSRSDELTRH IRIHTGQKPF QCRICMRNFS
360 370 380 390 400
RSDHLTTHIR THTGEKPFAC DICGRKFARS DERKRHTKIH LRQKDKKVEK
410 420 430 440 450
AASVSATSSS VAAYSSSVAT SYSSSIATTY PSPVRTVYSS PASSSYPSPA
460 470 480 490 500
HTTFPSPSIA TTYSSGTATF QTQVATSFPS PGVTNNFSSQ VTSALSDMTS
510
TFSPRTIEIC
Length:510
Mass (Da):55,351
Last modified:November 23, 2004 - v1
Checksum:i90B21EC163D95E4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719635 mRNA. Translation: CAG31294.1.
RefSeqiNP_989467.2. NM_204136.2.
UniGeneiGga.4922.

Genome annotation databases

GeneIDi373931.
KEGGigga:373931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719635 mRNA. Translation: CAG31294.1.
RefSeqiNP_989467.2. NM_204136.2.
UniGeneiGga.4922.

3D structure databases

ProteinModelPortaliQ5ZLU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012417.

Proteomic databases

PaxDbiQ5ZLU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373931.
KEGGigga:373931.

Organism-specific databases

CTDi1958.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000036856.
HOVERGENiHBG003909.
KOiK09203.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021839. DUF3432.
IPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11914. DUF3432. 1 hit.
PF11928. DUF3446. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5ZLU9_CHICK
AccessioniPrimary (citable) accession number: Q5ZLU9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.