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Protein

Putative oxidoreductase GLYR1

Gene

GLYR1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of MAPK14 and specifically regulating MAPK14 signaling.By similarity

Miscellaneous

The conserved NAD-binding sites and sequence similarity to plant dehydrogenases suggest that this protein may have oxidoreductase activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei362NADBy similarity1
Binding sitei505NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi168 – 180A.T hookCuratedAdd BLAST13
Nucleotide bindingi271 – 285NADBy similarityAdd BLAST15

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, Oxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative oxidoreductase GLYR1 (EC:1.-.-.-)
Alternative name(s):
Glyoxylate reductase 1 homolog
Nuclear protein NP60
Gene namesi
Name:GLYR1
Synonyms:NP60
ORF Names:RCJMB04_4p18
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121251 – 553Putative oxidoreductase GLYR1Add BLAST553

Proteomic databases

PaxDbiQ5ZLS7.
PRIDEiQ5ZLS7.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002823.

Structurei

3D structure databases

ProteinModelPortaliQ5ZLS7.
SMRiQ5ZLS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 66PWWPPROSITE-ProRule annotationAdd BLAST59

Domaini

The PWWP domain probably mediates the binding to H3K36me3.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0409. Eukaryota.
KOG1904. Eukaryota.
COG2084. LUCA.
HOGENOMiHOG000219609.
InParanoidiQ5ZLS7.
PhylomeDBiQ5ZLS7.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006115. 6PGDH_NADP-bd.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
IPR000313. PWWP_dom.
PfamiView protein in Pfam
PF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
PF00855. PWWP. 1 hit.
SMARTiView protein in SMART
SM00293. PWWP. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS50812. PWWP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZLS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVSLRLGD LVWGKLGRYP PWPGKIVNPP KDLKKPRGKK CFFVKFFGTE
60 70 80 90 100
DHAWIKVEQL KPYHLHKEEM IKINKGKRFQ QAVDAVEEFL RKTKGKDQAS
110 120 130 140 150
SHNSSEEKNR RNSSEERGKQ SAREEKRKAS LSEGKLKKGT GEGKKRVSSV
160 170 180 190 200
SSERGSKSPL KRAQDQSPRK RGRPPKDEKD LTIPESSTVK RVMTGTVAGF
210 220 230 240 250
KWPPSVSEPV KDSDPHFHHF LLSQTEKPAV CYQAITKKLK VCEEETGSTS
260 270 280 290 300
IQAADSTAVN GSITPTDKKI GFLGLGLMGS GIVSNLLKMG HTVTVWNRTA
310 320 330 340 350
EKCDLFIQEG ARLGRTPAEV VSTCDITFAC VSDPKAAKDL VLGPSGVLQG
360 370 380 390 400
IRPGKCYVDM STVDADTVTE LAQVIVSRGG RFLEAPVSGN QQLSNDGMLV
410 420 430 440 450
ILAAGDRGLY EDCSSCFQAM GKTSFFLGEV GNAAKMMLIV NMVQGSFMAT
460 470 480 490 500
IAEGLTLAQV TGQSQQTLLD ILNQGQLASI FLDQKCQNIL QGNFKPDFYL
510 520 530 540 550
KYIQKDLRLA IALGDSVNHP TPMAAAANEV YKRAKALDQS DNDMSAVYRA

YIH
Length:553
Mass (Da):60,601
Last modified:November 23, 2004 - v1
Checksum:i707C3C476C82FF1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719657 mRNA. Translation: CAG31316.1.
RefSeqiNP_001006572.1. NM_001006572.2.
UniGeneiGga.41977.

Genome annotation databases

GeneIDi426988.
KEGGigga:426988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719657 mRNA. Translation: CAG31316.1.
RefSeqiNP_001006572.1. NM_001006572.2.
UniGeneiGga.41977.

3D structure databases

ProteinModelPortaliQ5ZLS7.
SMRiQ5ZLS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002823.

Proteomic databases

PaxDbiQ5ZLS7.
PRIDEiQ5ZLS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi426988.
KEGGigga:426988.

Organism-specific databases

CTDi84656.

Phylogenomic databases

eggNOGiKOG0409. Eukaryota.
KOG1904. Eukaryota.
COG2084. LUCA.
HOGENOMiHOG000219609.
InParanoidiQ5ZLS7.
PhylomeDBiQ5ZLS7.

Miscellaneous databases

PROiPR:Q5ZLS7.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006115. 6PGDH_NADP-bd.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
IPR000313. PWWP_dom.
PfamiView protein in Pfam
PF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
PF00855. PWWP. 1 hit.
SMARTiView protein in SMART
SM00293. PWWP. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS50812. PWWP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLYR1_CHICK
AccessioniPrimary (citable) accession number: Q5ZLS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 23, 2004
Last modified: March 15, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.