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Protein

E3 ubiquitin-protein ligase BRE1A

Gene

RNF20

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively).By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri931 – 970RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Transferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase BRE1A (EC:2.3.2.27By similarity)
Short name:
BRE1-A
Alternative name(s):
RING finger protein 20
RING-type E3 ubiquitin transferase BRE1ACurated
Gene namesi
Name:RNF20
Synonyms:BRE1A
ORF Names:RCJMB04_5a23
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000558381 – 984E3 ubiquitin-protein ligase BRE1AAdd BLAST984

Proteomic databases

PaxDbiQ5ZLS3.
PRIDEiQ5ZLS3.

Interactioni

Subunit structurei

Component of the RNF20/40 complex (also known as BRE1 complex).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025019.

Structurei

3D structure databases

ProteinModelPortaliQ5ZLS3.
SMRiQ5ZLS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili43 – 90Sequence analysisAdd BLAST48
Coiled coili236 – 378Sequence analysisAdd BLAST143
Coiled coili429 – 907Sequence analysisAdd BLAST479

Sequence similaritiesi

Belongs to the BRE1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri931 – 970RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG0978. Eukaryota.
ENOG410Y5C6. LUCA.
HOGENOMiHOG000231526.
HOVERGENiHBG080312.
InParanoidiQ5ZLS3.
KOiK10696.
PhylomeDBiQ5ZLS3.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZLS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGAGNKRAA GEPGPSAPPE KKAGVEDSGT TVETIKLGGV SSTEELDIRT
60 70 80 90 100
LQTKNRKLAE MLDQRQAIED ELREHIEKLE RRQATDDASL LIINRYWNQF
110 120 130 140 150
DENIRIILKR FDLDQGLGDL LSERKALVVP EPEPDSDSNQ ERKDERERGE
160 170 180 190 200
GLEPAFSFLA TLASSTSEEI ESQLQERVES SRRAVAQIVT MYDKLQEKVD
210 220 230 240 250
VLSHKLNSGD ISLMEEAVLE LNSYLSHENG RLQELADTLQ EKHRIMSQEF
260 270 280 290 300
SKLQEKVETA ESRVSVLETM IDDLQWNIDK IRKREQRLNR HLADVLERVN
310 320 330 340 350
SKGYKVYGAG SSLYGGTITI NARKFEEMNA ELEENKELAG NRLNELEELR
360 370 380 390 400
HDLQEVTTQN EKLKVELRRA VEEAVKETPE YRCMQSQFSV LYNESLQLKA
410 420 430 440 450
HLDEARTLLH GTRTTHQRQV ELIERDEVSL HKKLRTEVMQ LEDTLAQVRK
460 470 480 490 500
EYEMLRIEFE QTLAANEQAG PINREMRHLI SSLQNHNHQL KGEVLRYKRK
510 520 530 540 550
LREAQSDLSK IRSRSGSALL QSQSSTEDTK EEPPEIKQEP DDPSSQVSAP
560 570 580 590 600
RAASEEASEV KARRDEEERE RERRERERER EKEKEKERER EKEKEKEKER
610 620 630 640 650
EREKQKQKES EKERESKEKE KGKHEDGRKK EAEVIKQLKA ELKKAQESQK
660 670 680 690 700
EMKLLLDMYR SAPKEQRDKV QLMAAEKKAK AELEELRQRV KELEDKEKKE
710 720 730 740 750
SKKMADEDAL RKIRAVEEQI EYLQKKLAMA KQEEEALLSE MDVTGQAFED
760 770 780 790 800
MQEQNIRLMQ QLREKDDANF KLMSERIKSN QIHKLLKEEK EELADQVLTL
810 820 830 840 850
KTQVDAQLQV VRKLEEKEHL LQSSIGTGEK ELGLRTQALE MNKRKAMDAA
860 870 880 890 900
QLADDLKTQL ELAQKKLHDF QDEIVESRVT REKEMFNFKR AEEDISRLRR
910 920 930 940 950
KLETTKKPDM VPNCDEILME EIKDYKARLT CPCCNMRKKD AVLTKCFHVF
960 970 980
CFECVKTRYD TRQRKCPKCN AAFGANDFHR IYIG
Length:984
Mass (Da):114,808
Last modified:November 23, 2004 - v1
Checksum:i61659ADF0A8FCB05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719661 mRNA. Translation: CAG31320.1.
RefSeqiNP_001026605.1. NM_001031434.1.
UniGeneiGga.42047.

Genome annotation databases

GeneIDi427310.
KEGGigga:427310.

Similar proteinsi

Entry informationi

Entry nameiBRE1A_CHICK
AccessioniPrimary (citable) accession number: Q5ZLS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 23, 2004
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families