Cytochrome b-c1 complex subunit Rieske, mitochondrial precursor

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Reviewed, UniProtKB/Swiss-Prot Q5ZLR5 (UCRI_CHICK)

Last modified February 9, 2010. Version 45. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Cytochrome b-c1 complex subunit Rieske, mitochondrial
    EC=1.10.2.2
Alternative name(s):
    Ubiquinol-cytochrome c reductase iron-sulfur subunit
    Rieske iron-sulfur protein
      Short name=RISP
    Complex III subunit 5

Gene names

Name:	UQCRFS1
ORF Names:	RCJMB04_5b19

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

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Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.
Catalytic activity	QH₂ + 2 ferricytochrome c = Q + 2 ferrocytochrome c + 2 H⁺.
Cofactor	Binds 1 2Fe-2S cluster per subunit By similarity.
Subunit structure	The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9 and UQCR11/QCR10) By similarity.
Subcellular location	Mitochondrion inner membrane By similarity.
Miscellaneous	The Rieske protein is a high potential 2Fe-2S protein.
Sequence similarities	Contains 1 Rieske domain.

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Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	3D-structure
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquinol-cytochrome-c reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 76

Mitochondrion By similarity

Chain

77 – 272

196

Cytochrome b-c1 complex subunit Rieske, mitochondrial

PRO_0000342403

Regions

Domain

185 – 270

Rieske

Sites

Metal binding

215

Iron-sulfur (2Fe-2S) By similarity

Metal binding

217

Iron-sulfur (2Fe-2S); via pros nitrogen By similarity

Metal binding

234

Iron-sulfur (2Fe-2S) By similarity

Metal binding

237

Iron-sulfur (2Fe-2S); via pros nitrogen By similarity

Amino acid modifications

Disulfide bond

220 ↔ 236

By similarity

Secondary structure

272

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q5ZLR5-1 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 3E60AD2419D26C25
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FASTA

272

29,387

        10         20         30         40         50         60 
MLSVAARSGP FAPYLSAAAH AVPGPLKALA PAALRAEKVV LDLKRPLLCR ESMSGRSARR 

        70         80         90        100        110        120 
DLVAGISLNA PASVRYVHND VTVPDFSAYR REDVMDATTS SQTSSEDRKG FSYLVTATAC 

       130        140        150        160        170        180 
VATAYAAKNV VTQFISSLSA SADVLALSKI EIKLSDIPEG KNVAFKWRGK PLFVRHRTQA 

       190        200        210        220        230        240 
EINQEAEVDV SKLRDPQHDL DRVKKPEWVI LVGVCTHLGC VPIANSGDFG GYYCPCHGSH 

       250        260        270 
YDASGRIRKG PAPYNLEVPT YQFVGDDLVV VG

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References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ719669 mRNA. Translation: CAG31328.1.

IPI

IPI00571043.

RefSeq

NP_001005843.1.

UniGene

Gga.5791

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3CWB	X-ray	3.51	I/V	45-76	[»]
3H1H	X-ray	3.16	E/R	77-272	[»]
			I/V	45-76	[»]
3H1I	X-ray	3.53	E/R	77-272	[»]
			I/V	45-76	[»]
3H1J	X-ray	3.00	E/R	77-272	[»]
			I/V	45-76	[»]
3H1K	X-ray	3.48	E/R	77-272	[»]
			I/V	45-76	[»]
3H1L	X-ray	3.21	E/R	77-272	[»]
			I/V	45-76	[»]

SMR

Q5ZLR5. Positions 1-55.

ModBase

Search...

Protein-protein interaction databases

STRING

Q5ZLR5.

Proteomic databases

PRIDE

Q5ZLR5.

Genome annotation databases

Ensembl

ENSGALT00000007087; ENSGALP00000007075; ENSGALG00000004452; Gallus gallus. [Genome view]

GeneID

415752.

KEGG

gga:415752.

Organism-specific databases

CTD

415752.

Phylogenomic databases

eggNOG

veNOG04796.

HOGENOM

HBG668715.

HOVERGEN

Q5ZLR5.

InParanoid

Q5ZLR5.

OMA

DYRRAEV.

OrthoDB

EOG9XH2KK.

PhylomeDB

Q5ZLR5.

Family and domain databases

InterPro

IPR011070. Globular_prot_asu/bsu.
IPR017941. Rieske_2Fe-2S.
IPR014349. Rieske_Fe-S_prot.
IPR005805. Rieske_Fe-S_prot_C.
IPR015248. Ubiqinol_cyt_c_Rdtase_N.
IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
IPR004192. Ubiquinol_cyt_Rdtase_TM.
[Graphical view]

Gene3D

G3DSA:2.102.10.10. Rieske_reg. 1 hit.

PANTHER

PTHR10134. Rieske. 1 hit.

Pfam

PF00355. Rieske. 1 hit.
PF09165. Ubiq-Cytc-red_N. 1 hit.
PF02921. UCR_TM. 1 hit.
[Graphical view]

PRINTS

PR00162. RIESKE.

TIGRFAMs

TIGR01416. Rieske_proteo. 1 hit.

PROSITE

PS51296. RIESKE. 1 hit.
[Graphical view]

ProtoNet

Search...

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Entry information

Entry name

UCRI_CHICK

Accession

Primary (citable) accession number: Q5ZLR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	November 23, 2004
Last modified:	February 9, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families