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Protein

Cytochrome b-c1 complex subunit Rieske, mitochondrial

Gene

UQCRFS1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.By similarity

Catalytic activityi

Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+.

Cofactori

[2Fe-2S] clusterPROSITE-ProRule annotationNote: Binds 1 [2Fe-2S] cluster per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi215Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi217Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation1
Metal bindingi234Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi237Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC:1.10.2.2)
Alternative name(s):
Complex III subunit 5
Rieske iron-sulfur protein
Short name:
RISP
Ubiquinol-cytochrome c reductase iron-sulfur subunit
Gene namesi
Name:UQCRFS1
ORF Names:RCJMB04_5b19
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 11

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei101 – 138HelicalAdd BLAST38

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 76MitochondrionBy similarityAdd BLAST76
ChainiPRO_000034240377 – 272Cytochrome b-c1 complex subunit Rieske, mitochondrialAdd BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi220 ↔ 236PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5ZLR5.

Expressioni

Gene expression databases

BgeeiENSGALG00000025819.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9 and UQCR11/QCR10).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000007075.

Structurei

Secondary structure

1272
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni51 – 55Combined sources5
Beta strandi64 – 70Combined sources7
Beta strandi73 – 75Combined sources3
Helixi78 – 80Combined sources3
Turni87 – 89Combined sources3
Helixi92 – 94Combined sources3
Turni101 – 104Combined sources4
Helixi105 – 137Combined sources33
Helixi142 – 146Combined sources5
Beta strandi150 – 152Combined sources3
Turni154 – 156Combined sources3
Beta strandi159 – 161Combined sources3
Beta strandi162 – 167Combined sources6
Beta strandi170 – 176Combined sources7
Beta strandi179 – 183Combined sources5
Turni184 – 186Combined sources3
Beta strandi193 – 195Combined sources3
Turni199 – 201Combined sources3
Beta strandi206 – 212Combined sources7
Turni216 – 218Combined sources3
Beta strandi223 – 225Combined sources3
Beta strandi230 – 234Combined sources5
Turni235 – 237Combined sources3
Beta strandi238 – 242Combined sources5
Turni243 – 245Combined sources3
Beta strandi249 – 251Combined sources3
Beta strandi265 – 267Combined sources3
Beta strandi268 – 271Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16E77-272[»]
2BCCX-ray3.50E77-272[»]
3BCCX-ray3.70E77-272[»]
3CWBX-ray3.51E/R77-272[»]
I/V45-76[»]
3H1HX-ray3.16E/R77-272[»]
I/V45-76[»]
3H1IX-ray3.53E/R77-272[»]
I/V45-76[»]
3H1JX-ray3.00E/R77-272[»]
I/V45-76[»]
3H1KX-ray3.48E/R77-272[»]
I/V45-76[»]
3H1LX-ray3.21E/R77-272[»]
I/V45-76[»]
3L70X-ray2.75E/R77-272[»]
I/V45-76[»]
3L71X-ray2.84E/R77-272[»]
I/V45-76[»]
3L72X-ray3.06E/R77-272[»]
I/V45-76[»]
3L73X-ray3.04E/R77-272[»]
I/V45-76[»]
3L74X-ray2.76E/R77-272[»]
I/V45-76[»]
3L75X-ray2.79E/R77-272[»]
I/V45-76[»]
3TGUX-ray2.70E/R77-272[»]
I/V2-76[»]
4U3FX-ray3.23E/R77-272[»]
I/V2-76[»]
ProteinModelPortaliQ5ZLR5.
SMRiQ5ZLR5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5ZLR5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 270RieskePROSITE-ProRule annotationAdd BLAST86

Sequence similaritiesi

Contains 1 Rieske domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1671. Eukaryota.
COG0723. LUCA.
GeneTreeiENSGT00390000001014.
HOGENOMiHOG000255193.
HOVERGENiHBG001040.
InParanoidiQ5ZLR5.
KOiK00411.
OMAiPFYEFPD.
OrthoDBiEOG091G0MOP.
PhylomeDBiQ5ZLR5.
TreeFamiTF105037.

Family and domain databases

Gene3Di1.20.5.270. 1 hit.
2.102.10.10. 1 hit.
InterProiIPR011070. Globular_prot_asu/bsu.
IPR017941. Rieske_2Fe-2S.
IPR014349. Rieske_Fe-S_prot.
IPR005805. Rieske_Fe-S_prot_C.
IPR015248. Ubiqinol_cyt_c_Rdtase_N.
IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
IPR004192. Ubiquinol_cyt_Rdtase_TM.
[Graphical view]
PANTHERiPTHR10134. PTHR10134. 1 hit.
PfamiPF00355. Rieske. 1 hit.
PF09165. Ubiq-Cytc-red_N. 1 hit.
PF02921. UCR_TM. 1 hit.
[Graphical view]
PRINTSiPR00162. RIESKE.
SUPFAMiSSF50022. SSF50022. 1 hit.
SSF56568. SSF56568. 1 hit.
TIGRFAMsiTIGR01416. Rieske_proteo. 1 hit.
PROSITEiPS51296. RIESKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZLR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSVAARSGP FAPYLSAAAH AVPGPLKALA PAALRAEKVV LDLKRPLLCR
60 70 80 90 100
ESMSGRSARR DLVAGISLNA PASVRYVHND VTVPDFSAYR REDVMDATTS
110 120 130 140 150
SQTSSEDRKG FSYLVTATAC VATAYAAKNV VTQFISSLSA SADVLALSKI
160 170 180 190 200
EIKLSDIPEG KNVAFKWRGK PLFVRHRTQA EINQEAEVDV SKLRDPQHDL
210 220 230 240 250
DRVKKPEWVI LVGVCTHLGC VPIANSGDFG GYYCPCHGSH YDASGRIRKG
260 270
PAPYNLEVPT YQFVGDDLVV VG
Length:272
Mass (Da):29,387
Last modified:November 23, 2004 - v1
Checksum:i3E60AD2419D26C25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719669 mRNA. Translation: CAG31328.1.
RefSeqiNP_001005843.1. NM_001005843.1.
UniGeneiGga.5791.

Genome annotation databases

EnsembliENSGALT00000044199; ENSGALP00000041886; ENSGALG00000025819.
GeneIDi415752.
KEGGigga:415752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719669 mRNA. Translation: CAG31328.1.
RefSeqiNP_001005843.1. NM_001005843.1.
UniGeneiGga.5791.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16E77-272[»]
2BCCX-ray3.50E77-272[»]
3BCCX-ray3.70E77-272[»]
3CWBX-ray3.51E/R77-272[»]
I/V45-76[»]
3H1HX-ray3.16E/R77-272[»]
I/V45-76[»]
3H1IX-ray3.53E/R77-272[»]
I/V45-76[»]
3H1JX-ray3.00E/R77-272[»]
I/V45-76[»]
3H1KX-ray3.48E/R77-272[»]
I/V45-76[»]
3H1LX-ray3.21E/R77-272[»]
I/V45-76[»]
3L70X-ray2.75E/R77-272[»]
I/V45-76[»]
3L71X-ray2.84E/R77-272[»]
I/V45-76[»]
3L72X-ray3.06E/R77-272[»]
I/V45-76[»]
3L73X-ray3.04E/R77-272[»]
I/V45-76[»]
3L74X-ray2.76E/R77-272[»]
I/V45-76[»]
3L75X-ray2.79E/R77-272[»]
I/V45-76[»]
3TGUX-ray2.70E/R77-272[»]
I/V2-76[»]
4U3FX-ray3.23E/R77-272[»]
I/V2-76[»]
ProteinModelPortaliQ5ZLR5.
SMRiQ5ZLR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000007075.

Proteomic databases

PaxDbiQ5ZLR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000044199; ENSGALP00000041886; ENSGALG00000025819.
GeneIDi415752.
KEGGigga:415752.

Organism-specific databases

CTDi7386.

Phylogenomic databases

eggNOGiKOG1671. Eukaryota.
COG0723. LUCA.
GeneTreeiENSGT00390000001014.
HOGENOMiHOG000255193.
HOVERGENiHBG001040.
InParanoidiQ5ZLR5.
KOiK00411.
OMAiPFYEFPD.
OrthoDBiEOG091G0MOP.
PhylomeDBiQ5ZLR5.
TreeFamiTF105037.

Enzyme and pathway databases

ReactomeiR-GGA-611105. Respiratory electron transport.

Miscellaneous databases

EvolutionaryTraceiQ5ZLR5.
PROiQ5ZLR5.

Gene expression databases

BgeeiENSGALG00000025819.

Family and domain databases

Gene3Di1.20.5.270. 1 hit.
2.102.10.10. 1 hit.
InterProiIPR011070. Globular_prot_asu/bsu.
IPR017941. Rieske_2Fe-2S.
IPR014349. Rieske_Fe-S_prot.
IPR005805. Rieske_Fe-S_prot_C.
IPR015248. Ubiqinol_cyt_c_Rdtase_N.
IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
IPR004192. Ubiquinol_cyt_Rdtase_TM.
[Graphical view]
PANTHERiPTHR10134. PTHR10134. 1 hit.
PfamiPF00355. Rieske. 1 hit.
PF09165. Ubiq-Cytc-red_N. 1 hit.
PF02921. UCR_TM. 1 hit.
[Graphical view]
PRINTSiPR00162. RIESKE.
SUPFAMiSSF50022. SSF50022. 1 hit.
SSF56568. SSF56568. 1 hit.
TIGRFAMsiTIGR01416. Rieske_proteo. 1 hit.
PROSITEiPS51296. RIESKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUCRI_CHICK
AccessioniPrimary (citable) accession number: Q5ZLR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The Rieske protein is a high potential 2Fe-2S protein.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.