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Protein

14-3-3 protein beta/alpha

Gene

YWHAB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-GGA-1445148. Translocation of GLUT4 to the plasma membrane.
R-GGA-165159. mTOR signalling.
R-GGA-166208. mTORC1-mediated signalling.
R-GGA-2028269. Signaling by Hippo.
R-GGA-392517. Rap1 signalling.
R-GGA-5628897. TP53 Regulates Metabolic Genes.
R-GGA-5673000. RAF activation.
R-GGA-5674135. MAP2K and MAPK activation.
R-GGA-5675221. Negative regulation of MAPK pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3 protein beta/alpha
Gene namesi
Name:YWHAB
ORF Names:RCJMB04_5d11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 20

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24424414-3-3 protein beta/alphaPRO_0000058597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei184 – 1841PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5ZLQ6.
PRIDEiQ5ZLQ6.

Interactioni

Subunit structurei

Homodimer, and heterodimer with other family members.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei56 – 561Interaction with phosphoserine on interacting proteinBy similarity
Sitei127 – 1271Interaction with phosphoserine on interacting proteinBy similarity

Protein-protein interaction databases

BioGridi680338. 1 interaction.
IntActiQ5ZLQ6. 1 interaction.
STRINGi9031.ENSGALP00000006578.

Structurei

3D structure databases

ProteinModelPortaliQ5ZLQ6.
SMRiQ5ZLQ6. Positions 1-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
HOVERGENiHBG050423.
InParanoidiQ5ZLQ6.
KOiK16197.
OMAiMGREYRE.
OrthoDBiEOG7HHWT3.
PhylomeDBiQ5ZLQ6.
TreeFamiTF102003.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZLQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKSELVQKA KLAEQAERYD DMAAAMKAVT EQGHELSNEE RNLLSVAYKN
60 70 80 90 100
VVGARRSSWR VISSIEQKTE RNEKKQQMGR EYREKIEAEL QDICNDVLEL
110 120 130 140 150
LDKYLIVNAT QPESKVFYLK MKGDYYRYLS EVASGDNKQT TVANSQQAYQ
160 170 180 190 200
EAFEISKKEM QPTHPIRLGL ALNFSVFYYE ILNSPEKACN LAKTAFDEAI
210 220 230 240
AELDTLNEES YKDSTLIMQL LRDNLTLWTS ENQGDEGDAG EGEN
Length:244
Mass (Da):27,907
Last modified:November 23, 2004 - v1
Checksum:i200272F6434A5254
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719678 mRNA. Translation: CAG31337.1.
RefSeqiNP_001006289.1. NM_001006289.1.
UniGeneiGga.34332.

Genome annotation databases

EnsembliENSGALT00000006588; ENSGALP00000006578; ENSGALG00000004143.
ENSGALT00000044506; ENSGALP00000043305; ENSGALG00000004143.
GeneIDi419190.
KEGGigga:419190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719678 mRNA. Translation: CAG31337.1.
RefSeqiNP_001006289.1. NM_001006289.1.
UniGeneiGga.34332.

3D structure databases

ProteinModelPortaliQ5ZLQ6.
SMRiQ5ZLQ6. Positions 1-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi680338. 1 interaction.
IntActiQ5ZLQ6. 1 interaction.
STRINGi9031.ENSGALP00000006578.

Proteomic databases

PaxDbiQ5ZLQ6.
PRIDEiQ5ZLQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000006588; ENSGALP00000006578; ENSGALG00000004143.
ENSGALT00000044506; ENSGALP00000043305; ENSGALG00000004143.
GeneIDi419190.
KEGGigga:419190.

Organism-specific databases

CTDi7529.

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
HOVERGENiHBG050423.
InParanoidiQ5ZLQ6.
KOiK16197.
OMAiMGREYRE.
OrthoDBiEOG7HHWT3.
PhylomeDBiQ5ZLQ6.
TreeFamiTF102003.

Enzyme and pathway databases

ReactomeiR-GGA-1445148. Translocation of GLUT4 to the plasma membrane.
R-GGA-165159. mTOR signalling.
R-GGA-166208. mTORC1-mediated signalling.
R-GGA-2028269. Signaling by Hippo.
R-GGA-392517. Rap1 signalling.
R-GGA-5628897. TP53 Regulates Metabolic Genes.
R-GGA-5673000. RAF activation.
R-GGA-5674135. MAP2K and MAPK activation.
R-GGA-5675221. Negative regulation of MAPK pathway.

Miscellaneous databases

PROiQ5ZLQ6.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry namei1433B_CHICK
AccessioniPrimary (citable) accession number: Q5ZLQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.