Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TAR DNA-binding protein 43

Gene

TARDBP

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in transcriptional repression.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor, RNA-binding
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TAR DNA-binding protein 43
Short name:
TDP-43
Gene namesi
Name:TARDBP
Synonyms:TDP43
ORF Names:RCJMB04_5g9
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174161 – 414TAR DNA-binding protein 43Add BLAST414

Proteomic databases

PaxDbiQ5ZLN5.
PRIDEiQ5ZLN5.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004576.

Structurei

3D structure databases

ProteinModelPortaliQ5ZLN5.
SMRiQ5ZLN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 200RRM 1PROSITE-ProRule annotationAdd BLAST97
Domaini191 – 262RRM 2PROSITE-ProRule annotationAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi274 – 413Gly-richAdd BLAST140

Domaini

The RRM domains can bind to both DNA and RNA.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IFJS. Eukaryota.
ENOG410ZYQJ. LUCA.
HOGENOMiHOG000254792.
HOVERGENiHBG058671.
InParanoidiQ5ZLN5.
PhylomeDBiQ5ZLN5.

Family and domain databases

InterProiView protein in InterPro
IPR035979. RBD_domain_sf.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 2 hits.
SMARTiView protein in SMART
SM00360. RRM. 2 hits.
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiView protein in PROSITE
PS50102. RRM. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5ZLN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC
60 70 80 90 100
MWGVRLVEGI LHAPEAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV
110 120 130 140 150
QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDIK TGHSKGFGFV
160 170 180 190 200
RFTDYETQVK VMSQRHMIDG RWCDCKLPNS KQSPDEPLRS RKVFVGRCTE
210 220 230 240 250
DMTADELQQF FAQYGEVVDV FIPKPFRAFA FVTFADDQVA QSLCGEDLII
260 270 280 290 300
KGISVHISNA EPKHNSNRQL ERGGRFGGNP GGFGNQGGFG NSRGGGGGLG
310 320 330 340 350
NNQGSNMGGG MNFGAFSINP AMMAAAQAAL QSSWGMMGML ASQQNQSGPS
360 370 380 390 400
GNNQPQGNMQ REQNQGFSSG NNSYGGSNSG AAIGWGSASN AGSSSGFNGG
410
FGSSMDSKSS GWGM
Length:414
Mass (Da):44,590
Last modified:November 23, 2004 - v1
Checksum:i17E7114DAB966DB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719699 mRNA. Translation: CAG31358.1.
RefSeqiNP_001026049.1. NM_001030878.1.
UniGeneiGga.16753.
Gga.56340.

Genome annotation databases

GeneIDi419453.
KEGGigga:419453.

Similar proteinsi

Entry informationi

Entry nameiTADBP_CHICK
AccessioniPrimary (citable) accession number: Q5ZLN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 23, 2004
Last modified: October 25, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome