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Protein

Phosphoglycerate mutase 1

Gene

PGAM1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.Curated

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.By similarity
3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.By similarity
2,3-bisphospho-D-glycerate + H2O = 3-phospho-D-glycerate + phosphate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111Tele-phosphohistidine intermediateBy similarity
Binding sitei62 – 621SubstrateBy similarity
Active sitei89 – 891Proton donor/acceptorBy similarity
Binding sitei100 – 1001SubstrateBy similarity
Sitei186 – 1861Transition state stabilizerBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Isomerase

Keywords - Biological processi

Glycolysis

Enzyme and pathway databases

ReactomeiR-GGA-352875. Gluconeogenesis.
R-GGA-352882. Glycolysis.
R-GGA-70171. Glycolysis.
R-GGA-70263. Gluconeogenesis.
SABIO-RKQ5ZLN1.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate mutase 1 (EC:3.1.3.13, EC:5.4.2.11, EC:5.4.2.4)
Alternative name(s):
BPG-dependent PGAM 1
Gene namesi
Name:PGAM1By similarity
ORF Names:RCJMB04_5g20
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 254253Phosphoglycerate mutase 1PRO_0000223502Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei26 – 261PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5ZLN1.
PRIDEiQ5ZLN1.

Expressioni

Gene expression databases

BgeeiENSGALG00000007606.
ExpressionAtlasiQ5ZLN1. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi687887. 2 interactions.
IntActiQ5ZLN1. 1 interaction.
STRINGi9031.ENSGALP00000038677.

Structurei

3D structure databases

ProteinModelPortaliQ5ZLN1.
SMRiQ5ZLN1. Positions 2-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 178Substrate bindingBy similarity
Regioni23 – 242Substrate bindingBy similarity
Regioni89 – 924Substrate bindingBy similarity
Regioni116 – 1172Substrate bindingBy similarity
Regioni187 – 1882Substrate bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi122 – 1254Poly-Pro

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0235. Eukaryota.
COG0588. LUCA.
HOGENOMiHOG000221682.
HOVERGENiHBG027528.
InParanoidiQ5ZLN1.
KOiK01834.
OrthoDBiEOG091G0GIS.
PhylomeDBiQ5ZLN1.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 2 hits.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZLN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAYRLVLVR HGESAWNLEN RFCGWYDADL SPAGQQEARR GGEALRDAGY
60 70 80 90 100
EFDICFTSVQ KRAIRTLWNV LDAIDQMWLP VVRTWRLNER HYGALTGLNK
110 120 130 140 150
AETAAKHGEA QVKIWRRSFD IPPPPMQSDH PFFSTISKDR RYADLTEDQL
160 170 180 190 200
PTCESLKDTI ARALPFWNEE IVPQIKEGKR VLIAAHGNSL RGIVKHLEGM
210 220 230 240 250
SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVR KAMEAVAAQG

KVKK
Length:254
Mass (Da):28,898
Last modified:January 23, 2007 - v3
Checksum:iE96705B2E5F7F227
GO

Mass spectrometryi

Molecular mass is 28769±1 Da from positions 2 - 254. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719703 mRNA. Translation: CAG31362.1.
RefSeqiNP_001026727.1. NM_001031556.1.
UniGeneiGga.6033.

Genome annotation databases

GeneIDi428969.
KEGGigga:428969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719703 mRNA. Translation: CAG31362.1.
RefSeqiNP_001026727.1. NM_001031556.1.
UniGeneiGga.6033.

3D structure databases

ProteinModelPortaliQ5ZLN1.
SMRiQ5ZLN1. Positions 2-246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi687887. 2 interactions.
IntActiQ5ZLN1. 1 interaction.
STRINGi9031.ENSGALP00000038677.

Proteomic databases

PaxDbiQ5ZLN1.
PRIDEiQ5ZLN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi428969.
KEGGigga:428969.

Organism-specific databases

CTDi5223.

Phylogenomic databases

eggNOGiKOG0235. Eukaryota.
COG0588. LUCA.
HOGENOMiHOG000221682.
HOVERGENiHBG027528.
InParanoidiQ5ZLN1.
KOiK01834.
OrthoDBiEOG091G0GIS.
PhylomeDBiQ5ZLN1.

Enzyme and pathway databases

ReactomeiR-GGA-352875. Gluconeogenesis.
R-GGA-352882. Glycolysis.
R-GGA-70171. Glycolysis.
R-GGA-70263. Gluconeogenesis.
SABIO-RKQ5ZLN1.

Miscellaneous databases

PROiQ5ZLN1.

Gene expression databases

BgeeiENSGALG00000007606.
ExpressionAtlasiQ5ZLN1. baseline.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 2 hits.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGAM1_CHICK
AccessioniPrimary (citable) accession number: Q5ZLN1
Secondary accession number(s): P84174
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.