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Protein

Parafibromin

Gene

CDC73

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Transcription

Enzyme and pathway databases

ReactomeiR-GGA-201722. Formation of the beta-catenin:TCF transactivating complex.
R-GGA-5632684. Hedgehog 'on' state.
R-GGA-674695. RNA Polymerase II Pre-transcription Events.
R-GGA-75955. RNA Polymerase II Transcription Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Parafibromin
Alternative name(s):
Cell division cycle protein 73 homolog
Gene namesi
Name:CDC73
ORF Names:RCJMB04_5j4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001918061 – 531ParafibrominAdd BLAST531

Proteomic databases

PaxDbiQ5ZLM0.
PRIDEiQ5ZLM0.

Expressioni

Gene expression databases

BgeeiENSGALG00000002469.

Interactioni

Subunit structurei

Component of the PAF1 complex, which at least consists of CDC73, PAF1, LEO1, CTR9 and RTF1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003888.

Structurei

3D structure databases

SMRiQ5ZLM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi125 – 139Nuclear localization signalBy similarityAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi361 – 364Poly-Ile4

Sequence similaritiesi

Belongs to the CDC73 family.Curated

Phylogenomic databases

eggNOGiKOG3786. Eukaryota.
COG5157. LUCA.
GeneTreeiENSGT00390000001114.
HOGENOMiHOG000007819.
HOVERGENiHBG055033.
InParanoidiQ5ZLM0.
KOiK15175.
OMAiKKLQGCQ.
OrthoDBiEOG091G0A8X.
PhylomeDBiQ5ZLM0.
TreeFamiTF313016.

Family and domain databases

InterProiView protein in InterPro
IPR007852. Cdc73/Parafibromin.
IPR031336. CDC73_C.
IPR032041. Cdc73_N.
PANTHERiPTHR12466. PTHR12466. 1 hit.
PfamiView protein in Pfam
PF05179. CDC73_C. 1 hit.
PF16050. CDC73_N. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZLM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVLSVLRQ YNTQKKEIVV KGDEVIFGEF SWPKNVKTNY VIWGTGKEGQ
60 70 80 90 100
PREYYTLDSI LFLLNNVHLS HPVYVRRAAT ENIPVVRRPD RKDLLAYLNG
110 120 130 140 150
ETSTSSSIDR SAPLEIGLQR STQVKRAADE ILAEAKKPRI EDEECVRLDK
160 170 180 190 200
ERLAARLEGH KEGIVQTEQI RSLSEAMSVE KIAAIKAKIM AKKRSTIKTD
210 220 230 240 250
LDDDITALKQ RSFVDAEVDV TRDIVSRERV WRTRTTILQS TGKNFAKNIF
260 270 280 290 300
AILQSVKARE EGRAPEQRPA PNTAPTDPTL RNKQPIPAAY NRYDQERFKG
310 320 330 340 350
KEETEGFKID TMGTYHGMTL KSVTEGASAR KTQTPAAQPV PRPVSQARPP
360 370 380 390 400
PNQKKGSRTP IIIIPAATTS LITMLNAKDL LQDLKFVPSD EKKKQGCQRE
410 420 430 440 450
NETLIQRRKD QMQPGGTTVS VTVPYRVVDQ PLKLMPQDWD RVVAVFVQGP
460 470 480 490 500
AWQFKGWPWL LPDGSPVDIF AKIKAFHLKY DEVRLDPNVQ KWDVTVLELS
510 520 530
YHKRHLDRPV FLRFWETLDR YMVKHKSHLR F
Length:531
Mass (Da):60,698
Last modified:November 23, 2004 - v1
Checksum:iFA5802D275629D04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719714 mRNA. Translation: CAG31373.1.
RefSeqiNP_001026436.1. NM_001031265.1.
UniGeneiGga.42090.

Genome annotation databases

EnsembliENSGALT00000003897; ENSGALP00000003888; ENSGALG00000002469.
GeneIDi424356.
KEGGigga:424356.

Similar proteinsi

Entry informationi

Entry nameiCDC73_CHICK
AccessioniPrimary (citable) accession number: Q5ZLM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 23, 2004
Last modified: September 27, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families