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Protein

Parafibromin

Gene

CDC73

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Transcription

Enzyme and pathway databases

ReactomeiR-GGA-201722. Formation of the beta-catenin:TCF transactivating complex.
R-GGA-5632684. Hedgehog 'on' state.

Names & Taxonomyi

Protein namesi
Recommended name:
Parafibromin
Alternative name(s):
Cell division cycle protein 73 homolog
Gene namesi
Name:CDC73
ORF Names:RCJMB04_5j4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531ParafibrominPRO_0000191806Add
BLAST

Proteomic databases

PaxDbiQ5ZLM0.
PRIDEiQ5ZLM0.

Interactioni

Subunit structurei

Component of the PAF1 complex, which at least consists of CDC73, PAF1, LEO1, CTR9 and RTF1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003888.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi125 – 13915Nuclear localization signalBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi361 – 3644Poly-Ile

Sequence similaritiesi

Belongs to the CDC73 family.Curated

Phylogenomic databases

eggNOGiKOG3786. Eukaryota.
COG5157. LUCA.
GeneTreeiENSGT00390000001114.
HOGENOMiHOG000007819.
HOVERGENiHBG055033.
InParanoidiQ5ZLM0.
KOiK15175.
OMAiKKLQGCQ.
OrthoDBiEOG7KM5SP.
PhylomeDBiQ5ZLM0.
TreeFamiTF313016.

Family and domain databases

InterProiIPR007852. Cdc73/Parafibromin.
IPR031336. CDC73_C.
IPR032041. Cdc73_N.
[Graphical view]
PANTHERiPTHR12466. PTHR12466. 2 hits.
PfamiPF05179. CDC73_C. 1 hit.
PF16050. CDC73_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZLM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVLSVLRQ YNTQKKEIVV KGDEVIFGEF SWPKNVKTNY VIWGTGKEGQ
60 70 80 90 100
PREYYTLDSI LFLLNNVHLS HPVYVRRAAT ENIPVVRRPD RKDLLAYLNG
110 120 130 140 150
ETSTSSSIDR SAPLEIGLQR STQVKRAADE ILAEAKKPRI EDEECVRLDK
160 170 180 190 200
ERLAARLEGH KEGIVQTEQI RSLSEAMSVE KIAAIKAKIM AKKRSTIKTD
210 220 230 240 250
LDDDITALKQ RSFVDAEVDV TRDIVSRERV WRTRTTILQS TGKNFAKNIF
260 270 280 290 300
AILQSVKARE EGRAPEQRPA PNTAPTDPTL RNKQPIPAAY NRYDQERFKG
310 320 330 340 350
KEETEGFKID TMGTYHGMTL KSVTEGASAR KTQTPAAQPV PRPVSQARPP
360 370 380 390 400
PNQKKGSRTP IIIIPAATTS LITMLNAKDL LQDLKFVPSD EKKKQGCQRE
410 420 430 440 450
NETLIQRRKD QMQPGGTTVS VTVPYRVVDQ PLKLMPQDWD RVVAVFVQGP
460 470 480 490 500
AWQFKGWPWL LPDGSPVDIF AKIKAFHLKY DEVRLDPNVQ KWDVTVLELS
510 520 530
YHKRHLDRPV FLRFWETLDR YMVKHKSHLR F
Length:531
Mass (Da):60,698
Last modified:November 23, 2004 - v1
Checksum:iFA5802D275629D04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719714 mRNA. Translation: CAG31373.1.
RefSeqiNP_001026436.1. NM_001031265.1.
UniGeneiGga.42090.

Genome annotation databases

EnsembliENSGALT00000003897; ENSGALP00000003888; ENSGALG00000002469.
GeneIDi424356.
KEGGigga:424356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719714 mRNA. Translation: CAG31373.1.
RefSeqiNP_001026436.1. NM_001031265.1.
UniGeneiGga.42090.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003888.

Proteomic databases

PaxDbiQ5ZLM0.
PRIDEiQ5ZLM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000003897; ENSGALP00000003888; ENSGALG00000002469.
GeneIDi424356.
KEGGigga:424356.

Organism-specific databases

CTDi79577.

Phylogenomic databases

eggNOGiKOG3786. Eukaryota.
COG5157. LUCA.
GeneTreeiENSGT00390000001114.
HOGENOMiHOG000007819.
HOVERGENiHBG055033.
InParanoidiQ5ZLM0.
KOiK15175.
OMAiKKLQGCQ.
OrthoDBiEOG7KM5SP.
PhylomeDBiQ5ZLM0.
TreeFamiTF313016.

Enzyme and pathway databases

ReactomeiR-GGA-201722. Formation of the beta-catenin:TCF transactivating complex.
R-GGA-5632684. Hedgehog 'on' state.

Miscellaneous databases

PROiQ5ZLM0.

Family and domain databases

InterProiIPR007852. Cdc73/Parafibromin.
IPR031336. CDC73_C.
IPR032041. Cdc73_N.
[Graphical view]
PANTHERiPTHR12466. PTHR12466. 2 hits.
PfamiPF05179. CDC73_C. 1 hit.
PF16050. CDC73_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiCDC73_CHICK
AccessioniPrimary (citable) accession number: Q5ZLM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.