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Reviewed, UniProtKB/Swiss-Prot Q5ZLL6 (ERG25_CHICK)

Last modified January 19, 2010. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    C-4 methylsterol oxidase
    EC=1.14.13.72
Alternative name(s):
    Methylsterol monooxygenase
Gene names
Name: SC4MOL
ORF Names: RCJMB04_5j19
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

4,4-dimethyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)+ + H2O.

4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O2 = 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)+ + 2 H2O.

3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)H + O2 = 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NAD(P)+ + H2O.

Cofactor

Iron By similarity.

Pathway

Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 3/6.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Probable.

Domain

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similarities

Belongs to the sterol desaturase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296C-4 methylsterol oxidase
PRO_0000249852

Regions

Transmembrane55 – 7521 Potential
Transmembrane100 – 12021 Potential
Transmembrane199 – 21921 Potential
Motif157 – 1615Histidine box-1 By similarity
Motif170 – 1745Histidine box-2 By similarity
Motif249 – 2557Histidine box-3 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZLL6-1 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 54144716232002A0

FASTA29635,485
        10         20         30         40         50         60 
MAVNDSVNIL NSAYLAVEYI DSFLPDNPLQ QPFKNAWNYM LDNYTKFQIA TWGSLLVHEA 

        70         80         90        100        110        120 
SYFLLCVPGF IFQFIPYMQK YKIQPDKPET WEKQWKCFKT LIFNHFFIQL PLICGTYYFT 

       130        140        150        160        170        180 
EYFNIPYEWE EMPRWYVLLA QCFGCAVIED AWHYFLHRLL HHKRIYKYIH KVHHEFVSPF 

       190        200        210        220        230        240 
GMQAEYAHPL ETLILGAGFF IGIVVFCNHV VLLWAWVICR LMETIDVHSG YDIPLNPLHL 

       250        260        270        280        290 
VPFYAGARFH DFHHMNFIGN YASTFTWWDR IFGTDSQFIA YKEKEKKQQL RMKKTN 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ719718 mRNA. Translation: CAG31377.1.
IPIIPI00578812.
RefSeqNP_001006438.1.
UniGeneGga.21297

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ5ZLL6.

Genome annotation databases

EnsemblENSGALT00000015566; ENSGALP00000015550; ENSGALG00000009560; Gallus gallus. [Genome view]
GeneID422423.
KEGGgga:422423.

Organism-specific databases

CTD422423.

Phylogenomic databases

eggNOGveNOG09290.
HOGENOMHBG325679.
HOVERGENQ5ZLL6.
InParanoidQ5ZLL6.
PhylomeDBQ5ZLL6.

Enzyme and pathway databases

BRENDA1.14.13.72. 4.

Family and domain databases

InterProIPR006694. Fatty_acid_hydroxylase.
[Graphical view]
PfamPF04116. FA_hydroxylase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameERG25_CHICK
AccessionPrimary (citable) accession number: Q5ZLL6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 23, 2004
Last modified: January 19, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents