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Protein

Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1

Gene

GBGT1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens (By similarity).By similarity

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi202 – 2021ManganeseBy similarity
Metal bindingi204 – 2041ManganeseBy similarity
Active sitei294 – 2941NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT6. Glycosyltransferase Family 6.

Names & Taxonomyi

Protein namesi
Recommended name:
Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (EC:2.4.1.-)
Alternative name(s):
Forssman glycolipid synthase-like protein
Gene namesi
Name:GBGT1
ORF Names:RCJMB04_5m5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence analysis
Transmembranei7 – 2721Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini28 – 343316LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1PRO_0000157297Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5ZLK4.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005275.

Structurei

3D structure databases

ProteinModelPortaliQ5ZLK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni112 – 1176Substrate bindingBy similarity
Regioni202 – 2043Substrate bindingBy similarity
Regioni224 – 2274Substrate bindingBy similarity

Domaini

The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity).By similarity

Sequence similaritiesi

Belongs to the glycosyltransferase 6 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFQJ. Eukaryota.
ENOG4111IPQ. LUCA.
HOGENOMiHOG000234339.
HOVERGENiHBG003563.
InParanoidiQ5ZLK4.
KOiK00722.
PhylomeDBiQ5ZLK4.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005076. Glyco_trans_6.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR10462. PTHR10462. 1 hit.
PfamiPF03414. Glyco_transf_6. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZLK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISRKALGSL VCLSAVATLI WIASGNWKVH YLPYYLPCPG IFSKKLQYLG
60 70 80 90 100
DKPVQLFPQL FYQQPRVLAP KRQDVLTVTP WLAPIVWEGT FSPEILDSAY
110 120 130 140 150
MPLNLTIGVT AFAVGKYTRF VSRFLKSAEM HFMKGYRVNY YIFTDNPKMI
160 170 180 190 200
PDVQLQPGRR FDVVHIKKYS SWQEISVRRM EAINLHIAER SHREVDYLFC
210 220 230 240 250
LDIDMVFHNA WGAETLGDMV AAIHPGYFNV PRSQFPYERR SSSAAYIPDG
260 270 280 290 300
EGDFYYGGAV FGGLVKKVYE FTKICHMTIL ADKANGIMAA WQEESHLNRH
310 320 330 340
FLTHKPSKLL SPEYLWDDRK PKPPEIFLIR FSTVDKNYQE VRN
Length:343
Mass (Da):39,652
Last modified:November 23, 2004 - v1
Checksum:iC5000B26218649C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719730 mRNA. Translation: CAG31389.1.
RefSeqiNP_001025854.1. NM_001030683.1.
UniGeneiGga.22209.

Genome annotation databases

GeneIDi417163.
KEGGigga:417163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719730 mRNA. Translation: CAG31389.1.
RefSeqiNP_001025854.1. NM_001030683.1.
UniGeneiGga.22209.

3D structure databases

ProteinModelPortaliQ5ZLK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005275.

Protein family/group databases

CAZyiGT6. Glycosyltransferase Family 6.

Proteomic databases

PaxDbiQ5ZLK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi417163.
KEGGigga:417163.

Organism-specific databases

CTDi26301.

Phylogenomic databases

eggNOGiENOG410IFQJ. Eukaryota.
ENOG4111IPQ. LUCA.
HOGENOMiHOG000234339.
HOVERGENiHBG003563.
InParanoidiQ5ZLK4.
KOiK00722.
PhylomeDBiQ5ZLK4.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

PROiQ5ZLK4.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005076. Glyco_trans_6.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR10462. PTHR10462. 1 hit.
PfamiPF03414. Glyco_transf_6. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiGBGT1_CHICK
AccessioniPrimary (citable) accession number: Q5ZLK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.