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Protein

Ras-related protein Rab-18

Gene

RAB18

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTPBy similarity
Nucleotide bindingi63 – 675GTPBy similarity
Nucleotide bindingi122 – 1254GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-18
Gene namesi
Name:RAB18
ORF Names:RCJMB04_6g4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Ras-related protein Rab-18PRO_0000121197Add
BLAST
Propeptidei204 – 2063Removed in mature formSequence analysisPRO_0000370765

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi199 – 1991S-palmitoyl cysteineSequence analysis
Modified residuei203 – 2031Cysteine methyl esterSequence analysis
Lipidationi203 – 2031S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ5ZLG1.
PRIDEiQ5ZLG1.

Interactioni

Protein-protein interaction databases

BioGridi681433. 1 interaction.
IntActiQ5ZLG1. 1 interaction.
STRINGi9031.ENSGALP00000012019.

Structurei

3D structure databases

ProteinModelPortaliQ5ZLG1.
SMRiQ5ZLG1. Positions 2-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0080. Eukaryota.
ENOG410XPD0. LUCA.
GeneTreeiENSGT00840000129698.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ5ZLG1.
KOiK07910.
OMAiSYYRDAQ.
OrthoDBiEOG7CVQ04.
PhylomeDBiQ5ZLG1.
TreeFamiTF313448.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZLG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI
60 70 80 90 100
SVDGNKAKLA IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD
110 120 130 140 150
NWLNELETYC TRNDIVKMLV GNKIDKENRE VDRNEGLKFA RKHSMLFIEA
160 170 180 190 200
SAKTCDGVQC AFEELVEKII QTPGLWESES QNKGVKLSNK EEGHGGGACG

GYCSML
Length:206
Mass (Da):22,954
Last modified:November 23, 2004 - v1
Checksum:iC312C672E72FDA22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719773 mRNA. Translation: CAG31432.1.
RefSeqiNP_001006355.1. NM_001006355.1.
UniGeneiGga.42447.

Genome annotation databases

EnsembliENSGALT00000012033; ENSGALP00000012019; ENSGALG00000007435.
GeneIDi420483.
KEGGigga:420483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719773 mRNA. Translation: CAG31432.1.
RefSeqiNP_001006355.1. NM_001006355.1.
UniGeneiGga.42447.

3D structure databases

ProteinModelPortaliQ5ZLG1.
SMRiQ5ZLG1. Positions 2-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi681433. 1 interaction.
IntActiQ5ZLG1. 1 interaction.
STRINGi9031.ENSGALP00000012019.

Proteomic databases

PaxDbiQ5ZLG1.
PRIDEiQ5ZLG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000012033; ENSGALP00000012019; ENSGALG00000007435.
GeneIDi420483.
KEGGigga:420483.

Organism-specific databases

CTDi22931.

Phylogenomic databases

eggNOGiKOG0080. Eukaryota.
ENOG410XPD0. LUCA.
GeneTreeiENSGT00840000129698.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ5ZLG1.
KOiK07910.
OMAiSYYRDAQ.
OrthoDBiEOG7CVQ04.
PhylomeDBiQ5ZLG1.
TreeFamiTF313448.

Enzyme and pathway databases

ReactomeiR-GGA-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiQ5ZLG1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiRAB18_CHICK
AccessioniPrimary (citable) accession number: Q5ZLG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.