Reviewed, UniProtKB/Swiss-Prot Q5ZLG0 (AACS_CHICK)

Names and origin

Protein names

Recommended name:
    Acetoacetyl-CoA synthetase
    EC=6.2.1.16

Gene names

Name:	AACS
ORF Names:	RCJMB04_6g9

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	667 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development By similarity.
Catalytic activity	ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.
Subcellular location	Cytoplasm › cytosol By similarity.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Biological process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetoacetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 667	667	Acetoacetyl-CoA synthetase		PRO_0000315788

Sequences

	Sequence		Length	Mass (Da)
	Q5ZLG0-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 17B6EE7757E85366	FASTA	667	74,370
	10 20 30 40 50 60 MSREPEIMES QVMWEPDSKR NTHMDRFRAA VAGSCGLRLA NYNDLYQWSV ESFADFWAEF 70 80 90 100 110 120 WKYSNIVCSR LYDEVVDTSK SIADVPEWFK GSRLNYAENL LKHKDNDKIA LYAAKEGKEE 130 140 150 160 170 180 ILKVTFEELR QAVALYAAAM RKMGVKIGDR VVGYLPNSIH AVEAMLAAAS IGAIWSSTSP 190 200 210 220 230 240 DFGINGVLDR FSQIQPKLIF SVEAVVYNGK EHNHLEKLLS VVKGLPDLKK VVVIPYVSSR 250 260 270 280 290 300 ETIDISKIPN SVFLEDFLAT GKGDQAPQLE FEQLPFSHPL FIMYSSGTTG APKCMVHSAG 310 320 330 340 350 360 GTLIQHLKEH ILHGNMSSND IIMYYTTTGW MMWNWLVTAL ATGASVVLYD GSPLVPSPNV 370 380 390 400 410 420 LWDLIDRLGI TILGTGAKWL AVLEEKNLKP CETHNLQTLH TILSTGSPLK SQSYEYVYKH 430 440 450 460 470 480 IKSSVLLGSI SGGTDIISCF MGQNVTIPVY KGEIQARNLG MAVEAWNDEG KPVWGESGEL 490 500 510 520 530 540 VCTKPIPCQP THFWNDENGS KYRKAYFSKF PGVWAHGDYC KINPKTGGIV MLGRSDGTLN 550 560 570 580 590 600 PNGVRFGSSE IYNIVEAFEE VSDSLCVPQY NKDGEERVIL FLKMASNHAF SEDLVKRIRD 610 620 630 640 650 660 AIRVALSARH VPSLILETKG IPYTINGKKV EVAVKQIIAG KEVEQRGAFS NPETLDLYQN IPELQNF

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:RESEARCH006.1-RESEARCH006.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ719774 mRNA. Translation: CAG31433.1.
IPI	IPI00822553.
RefSeq	NP_001006184.1.
UniGene	Gga.22600
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSGALG00000002899. Gallus gallus. [Contig view]
GeneID	416811.
KEGG	gga:416811.
Phylogenomic databases
HOGENOM	Q5ZLG0.
HOVERGEN	Q5ZLG0.
Enzyme and pathway databases
BRENDA	6.2.1.16. 4.
Family and domain databases
InterPro	IPR005914. Acac_CoA_synth. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR01217. ac_ac_CoA_syn. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AACS_CHICK

Accession

Primary (citable) accession number: Q5ZLG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 23, 2004
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)