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Protein

Acetoacetyl-CoA synthetase

Gene

AACS

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).By similarity

Catalytic activityi

ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-77111. Synthesis of Ketone Bodies.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetoacetyl-CoA synthetase (EC:6.2.1.16)
Gene namesi
Name:AACS
ORF Names:RCJMB04_6g9
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 667667Acetoacetyl-CoA synthetasePRO_0000315788Add
BLAST

Proteomic databases

PaxDbiQ5ZLG0.
PRIDEiQ5ZLG0.

Expressioni

Gene expression databases

ExpressionAtlasiQ5ZLG0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004568.

Structurei

3D structure databases

ProteinModelPortaliQ5ZLG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
HOGENOMiHOG000229992.
HOVERGENiHBG059947.
InParanoidiQ5ZLG0.
KOiK01907.
PhylomeDBiQ5ZLG0.

Family and domain databases

InterProiIPR005914. Acac_CoA_synth.
IPR032387. ACAS_N.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01217. ac_ac_CoA_syn. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZLG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSREPEIMES QVMWEPDSKR NTHMDRFRAA VAGSCGLRLA NYNDLYQWSV
60 70 80 90 100
ESFADFWAEF WKYSNIVCSR LYDEVVDTSK SIADVPEWFK GSRLNYAENL
110 120 130 140 150
LKHKDNDKIA LYAAKEGKEE ILKVTFEELR QAVALYAAAM RKMGVKIGDR
160 170 180 190 200
VVGYLPNSIH AVEAMLAAAS IGAIWSSTSP DFGINGVLDR FSQIQPKLIF
210 220 230 240 250
SVEAVVYNGK EHNHLEKLLS VVKGLPDLKK VVVIPYVSSR ETIDISKIPN
260 270 280 290 300
SVFLEDFLAT GKGDQAPQLE FEQLPFSHPL FIMYSSGTTG APKCMVHSAG
310 320 330 340 350
GTLIQHLKEH ILHGNMSSND IIMYYTTTGW MMWNWLVTAL ATGASVVLYD
360 370 380 390 400
GSPLVPSPNV LWDLIDRLGI TILGTGAKWL AVLEEKNLKP CETHNLQTLH
410 420 430 440 450
TILSTGSPLK SQSYEYVYKH IKSSVLLGSI SGGTDIISCF MGQNVTIPVY
460 470 480 490 500
KGEIQARNLG MAVEAWNDEG KPVWGESGEL VCTKPIPCQP THFWNDENGS
510 520 530 540 550
KYRKAYFSKF PGVWAHGDYC KINPKTGGIV MLGRSDGTLN PNGVRFGSSE
560 570 580 590 600
IYNIVEAFEE VSDSLCVPQY NKDGEERVIL FLKMASNHAF SEDLVKRIRD
610 620 630 640 650
AIRVALSARH VPSLILETKG IPYTINGKKV EVAVKQIIAG KEVEQRGAFS
660
NPETLDLYQN IPELQNF
Length:667
Mass (Da):74,370
Last modified:November 23, 2004 - v1
Checksum:i17B6EE7757E85366
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719774 mRNA. Translation: CAG31433.1.
RefSeqiNP_001006184.1. NM_001006184.1.
UniGeneiGga.22600.

Genome annotation databases

GeneIDi416811.
KEGGigga:416811.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719774 mRNA. Translation: CAG31433.1.
RefSeqiNP_001006184.1. NM_001006184.1.
UniGeneiGga.22600.

3D structure databases

ProteinModelPortaliQ5ZLG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004568.

Proteomic databases

PaxDbiQ5ZLG0.
PRIDEiQ5ZLG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi416811.
KEGGigga:416811.

Organism-specific databases

CTDi65985.

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
HOGENOMiHOG000229992.
HOVERGENiHBG059947.
InParanoidiQ5ZLG0.
KOiK01907.
PhylomeDBiQ5ZLG0.

Enzyme and pathway databases

ReactomeiR-GGA-77111. Synthesis of Ketone Bodies.

Miscellaneous databases

PROiQ5ZLG0.

Gene expression databases

ExpressionAtlasiQ5ZLG0. baseline and differential.

Family and domain databases

InterProiIPR005914. Acac_CoA_synth.
IPR032387. ACAS_N.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01217. ac_ac_CoA_syn. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiAACS_CHICK
AccessioniPrimary (citable) accession number: Q5ZLG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.