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Protein

Eukaryotic translation initiation factor 3 subunit H

Gene

EIF3H

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-GGA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-GGA-72702. Ribosomal scanning and start codon recognition.

Protein family/group databases

MEROPSiM67.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit HUniRule annotation
Short name:
eIF3hUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 3UniRule annotation
eIF-3-gamma
eIF3 p40 subunitUniRule annotation
Gene namesi
Name:EIF3HUniRule annotation
Synonyms:EIF3S3UniRule annotation
ORF Names:RCJMB04_6i8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Eukaryotic translation initiation factor 3 subunit HPRO_0000365174Add
BLAST

Proteomic databases

PaxDbiQ5ZLE6.
PRIDEiQ5ZLE6.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.UniRule annotation

Protein-protein interaction databases

BioGridi681277. 1 interaction.
STRINGi9031.ENSGALP00000025924.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 142113MPNUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit H family.UniRule annotation
Contains 1 MPN (JAB/Mov34) domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1560. Eukaryota.
ENOG410XSR9. LUCA.
GeneTreeiENSGT00730000111042.
HOGENOMiHOG000248787.
HOVERGENiHBG000883.
InParanoidiQ5ZLE6.
KOiK03247.
OMAiQEEGQGN.
OrthoDBiEOG7992RH.
PhylomeDBiQ5ZLE6.
TreeFamiTF101504.

Family and domain databases

HAMAPiMF_03007. eIF3h.
InterProiIPR027524. eIF3h.
IPR000555. JAMM/MPN+_dom.
[Graphical view]
PANTHERiPTHR10410:SF3. PTHR10410:SF3. 2 hits.
PfamiPF01398. JAB. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZLE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRKEGSGA AGGGFGASKG KGKAATTGDS AVKQVQIDGL VVLKIIKHYQ
60 70 80 90 100
EEGQGNEVVQ GVLLGLVVDD RLEITNCFPF PQHTEDDADF DEVQYQMEMM
110 120 130 140 150
RSLRHVNIDH LHVGWYQSTY YGSFVTRALL DSQFSYQHAI EESVVLIYDP
160 170 180 190 200
IKTAQGSLSL KAYRLTPKLM EVCKEKDFSP EALKKANIAY ENMFEEVPIV
210 220 230 240 250
IKNSYLINVM LWELEKKSAV ADRHELLSLA SSNHLGKSLQ LLMDRVDEMS
260 270 280 290 300
QDIVKYNTYL RNVSKQQQQK HQYQQRRQQE NLQRQSRGEA PLPEEDINKL
310 320 330 340
FKPPQPPARM ESLLIAGQIN TYCQNIKEFN AQNLGKLFMA QALQDYNN
Length:348
Mass (Da):39,537
Last modified:November 23, 2004 - v1
Checksum:i034A361FCA60FA61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719788 mRNA. Translation: CAG31447.1.
RefSeqiNP_001026122.1. NM_001030951.1.
UniGeneiGga.4721.

Genome annotation databases

EnsembliENSGALT00000025971; ENSGALP00000025924; ENSGALG00000016122.
GeneIDi420288.
KEGGigga:420288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719788 mRNA. Translation: CAG31447.1.
RefSeqiNP_001026122.1. NM_001030951.1.
UniGeneiGga.4721.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi681277. 1 interaction.
STRINGi9031.ENSGALP00000025924.

Protein family/group databases

MEROPSiM67.971.

Proteomic databases

PaxDbiQ5ZLE6.
PRIDEiQ5ZLE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000025971; ENSGALP00000025924; ENSGALG00000016122.
GeneIDi420288.
KEGGigga:420288.

Organism-specific databases

CTDi8667.

Phylogenomic databases

eggNOGiKOG1560. Eukaryota.
ENOG410XSR9. LUCA.
GeneTreeiENSGT00730000111042.
HOGENOMiHOG000248787.
HOVERGENiHBG000883.
InParanoidiQ5ZLE6.
KOiK03247.
OMAiQEEGQGN.
OrthoDBiEOG7992RH.
PhylomeDBiQ5ZLE6.
TreeFamiTF101504.

Enzyme and pathway databases

ReactomeiR-GGA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-GGA-72702. Ribosomal scanning and start codon recognition.

Miscellaneous databases

PROiQ5ZLE6.

Family and domain databases

HAMAPiMF_03007. eIF3h.
InterProiIPR027524. eIF3h.
IPR000555. JAMM/MPN+_dom.
[Graphical view]
PANTHERiPTHR10410:SF3. PTHR10410:SF3. 2 hits.
PfamiPF01398. JAB. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiEIF3H_CHICK
AccessioniPrimary (citable) accession number: Q5ZLE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.