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Protein

Microtubule-associated protein RP/EB family member 1

Gene

MAPRE1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-GGA-2467813. Separation of Sister Chromatids.
R-GGA-2500257. Resolution of Sister Chromatid Cohesion.
R-GGA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-GGA-380259. Loss of Nlp from mitotic centrosomes.
R-GGA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-GGA-5620912. Anchoring of the basal body to the plasma membrane.
R-GGA-5663220. RHO GTPases Activate Formins.
R-GGA-68877. Mitotic Prometaphase.
R-GGA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-GGA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein RP/EB family member 1
Gene namesi
Name:MAPRE1
ORF Names:RCJMB04_6l6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 20

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmcytoskeleton By similarity
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity

  • Note: Associated with the microtubule network at the growing distal tip of microtubules. Detected along microtubules. Also enriched at the centrosome (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Microtubule-associated protein RP/EB family member 1PRO_0000213421Add
BLAST

Proteomic databases

PaxDbiQ5ZLC7.
PRIDEiQ5ZLC7.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010754.

Structurei

3D structure databases

ProteinModelPortaliQ5ZLC7.
SMRiQ5ZLC7. Positions 1-130, 181-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 116103CHPROSITE-ProRule annotationAdd
BLAST
Domaini175 – 24571EB1 C-terminalPROSITE-ProRule annotationAdd
BLAST

Domaini

The N-terminal domain may form a hydrophobic cleft involved in microtubule binding and the C-terminal may be involved in the formation of mutually exclusive complexes with APC and DCTN1.By similarity

Sequence similaritiesi

Belongs to the MAPRE family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 EB1 C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3000. Eukaryota.
COG5217. LUCA.
GeneTreeiENSGT00490000043329.
HOGENOMiHOG000198048.
HOVERGENiHBG052410.
InParanoidiQ5ZLC7.
KOiK10436.
OMAiIQNYKII.
OrthoDBiEOG7ZD1W5.
PhylomeDBiQ5ZLC7.
TreeFamiTF313620.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR004953. EB1_C.
IPR027328. MAPRE.
[Graphical view]
PANTHERiPTHR10623. PTHR10623. 1 hit.
PfamiPF00307. CH. 1 hit.
PF03271. EB1. 1 hit.
[Graphical view]
SUPFAMiSSF140612. SSF140612. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51230. EB1_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZLC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVNVYSTSV TSDNLSRHDM LAWINESLQL TLTKIEQLCS GAAYCQFMDM
60 70 80 90 100
LFPGSVALKK VKFQAKLEHE YIQNFKVLQA GFKRMGVDKI IPVDKLVKGK
110 120 130 140 150
FQDNFEFVQW FKKFFDANYD GKEYDPVAAR QGQETVAPNL VAPVVNKPKK
160 170 180 190 200
PLAPQRPIVA QRTPATPKGS TGMVKKAAGD DESAGLIEQI NVLKLTVEDL
210 220 230 240 250
EKERDFYFGK LRNIELICQE NEGENDPVLQ RIVEILYATD EGFVIPDEGA

PQEEQEEY
Length:258
Mass (Da):29,143
Last modified:November 23, 2004 - v1
Checksum:i752FEB40D1033F52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719807 mRNA. Translation: CAG31466.1.
RefSeqiNP_001026031.1. NM_001030860.1.
UniGeneiGga.16800.

Genome annotation databases

EnsembliENSGALT00000010768; ENSGALP00000010754; ENSGALG00000006657.
GeneIDi419288.
KEGGigga:419288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719807 mRNA. Translation: CAG31466.1.
RefSeqiNP_001026031.1. NM_001030860.1.
UniGeneiGga.16800.

3D structure databases

ProteinModelPortaliQ5ZLC7.
SMRiQ5ZLC7. Positions 1-130, 181-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010754.

Proteomic databases

PaxDbiQ5ZLC7.
PRIDEiQ5ZLC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000010768; ENSGALP00000010754; ENSGALG00000006657.
GeneIDi419288.
KEGGigga:419288.

Organism-specific databases

CTDi22919.

Phylogenomic databases

eggNOGiKOG3000. Eukaryota.
COG5217. LUCA.
GeneTreeiENSGT00490000043329.
HOGENOMiHOG000198048.
HOVERGENiHBG052410.
InParanoidiQ5ZLC7.
KOiK10436.
OMAiIQNYKII.
OrthoDBiEOG7ZD1W5.
PhylomeDBiQ5ZLC7.
TreeFamiTF313620.

Enzyme and pathway databases

ReactomeiR-GGA-2467813. Separation of Sister Chromatids.
R-GGA-2500257. Resolution of Sister Chromatid Cohesion.
R-GGA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-GGA-380259. Loss of Nlp from mitotic centrosomes.
R-GGA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-GGA-5620912. Anchoring of the basal body to the plasma membrane.
R-GGA-5663220. RHO GTPases Activate Formins.
R-GGA-68877. Mitotic Prometaphase.
R-GGA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-GGA-8854518. AURKA Activation by TPX2.

Miscellaneous databases

PROiQ5ZLC7.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR004953. EB1_C.
IPR027328. MAPRE.
[Graphical view]
PANTHERiPTHR10623. PTHR10623. 1 hit.
PfamiPF00307. CH. 1 hit.
PF03271. EB1. 1 hit.
[Graphical view]
SUPFAMiSSF140612. SSF140612. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51230. EB1_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiMARE1_CHICK
AccessioniPrimary (citable) accession number: Q5ZLC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.