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Protein

Microtubule-associated protein RP/EB family member 1

Gene

MAPRE1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-GGA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-GGA-2467813 Separation of Sister Chromatids
R-GGA-2500257 Resolution of Sister Chromatid Cohesion
R-GGA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-GGA-380259 Loss of Nlp from mitotic centrosomes
R-GGA-380270 Recruitment of mitotic centrosome proteins and complexes
R-GGA-380320 Recruitment of NuMA to mitotic centrosomes
R-GGA-5620912 Anchoring of the basal body to the plasma membrane
R-GGA-5663220 RHO GTPases Activate Formins
R-GGA-68877 Mitotic Prometaphase
R-GGA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-GGA-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein RP/EB family member 1
Gene namesi
Name:MAPRE1
ORF Names:RCJMB04_6l6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002134211 – 258Microtubule-associated protein RP/EB family member 1Add BLAST258

Proteomic databases

PaxDbiQ5ZLC7
PRIDEiQ5ZLC7

Expressioni

Gene expression databases

BgeeiENSGALG00000006657

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010754

Structurei

3D structure databases

ProteinModelPortaliQ5ZLC7
SMRiQ5ZLC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 116Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST103
Domaini175 – 245EB1 C-terminalPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Belongs to the MAPRE family.Curated

Phylogenomic databases

eggNOGiKOG3000 Eukaryota
COG5217 LUCA
HOGENOMiHOG000198048
HOVERGENiHBG052410
InParanoidiQ5ZLC7
KOiK10436
OMAiCQVFDSI
OrthoDBiEOG091G0FT4
PhylomeDBiQ5ZLC7
TreeFamiTF313620

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR004953 EB1_C
IPR036133 EB1_C_sf
IPR027739 EB1_Meta
IPR027328 MAPRE
PANTHERiPTHR10623 PTHR10623, 1 hit
PTHR10623:SF20 PTHR10623:SF20, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF03271 EB1, 1 hit
SUPFAMiSSF140612 SSF140612, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51230 EB1_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZLC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVNVYSTSV TSDNLSRHDM LAWINESLQL TLTKIEQLCS GAAYCQFMDM
60 70 80 90 100
LFPGSVALKK VKFQAKLEHE YIQNFKVLQA GFKRMGVDKI IPVDKLVKGK
110 120 130 140 150
FQDNFEFVQW FKKFFDANYD GKEYDPVAAR QGQETVAPNL VAPVVNKPKK
160 170 180 190 200
PLAPQRPIVA QRTPATPKGS TGMVKKAAGD DESAGLIEQI NVLKLTVEDL
210 220 230 240 250
EKERDFYFGK LRNIELICQE NEGENDPVLQ RIVEILYATD EGFVIPDEGA

PQEEQEEY
Length:258
Mass (Da):29,143
Last modified:November 23, 2004 - v1
Checksum:i752FEB40D1033F52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719807 mRNA Translation: CAG31466.1
RefSeqiNP_001026031.1, NM_001030860.1
UniGeneiGga.16800

Genome annotation databases

GeneIDi419288
KEGGigga:419288

Similar proteinsi

Entry informationi

Entry nameiMARE1_CHICK
AccessioniPrimary (citable) accession number: Q5ZLC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 23, 2004
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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