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Protein

Vesicle-associated membrane protein 7

Gene

VAMP7

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • calcium ion regulated exocytosis Source: UniProtKB
  • endocytosis Source: GO_Central
  • endosome to lysosome transport Source: UniProtKB
  • eosinophil degranulation Source: UniProtKB
  • ER to Golgi vesicle-mediated transport Source: UniProtKB
  • exocytosis Source: GO_Central
  • Golgi to plasma membrane protein transport Source: Ensembl
  • natural killer cell degranulation Source: Ensembl
  • neutrophil degranulation Source: UniProtKB
  • phagocytosis, engulfment Source: UniProtKB
  • positive regulation of dendrite morphogenesis Source: Ensembl
  • positive regulation of histamine secretion by mast cell Source: Ensembl
  • regulation of protein targeting to vacuolar membrane Source: Ensembl
  • SNARE complex assembly Source: Ensembl
  • vesicle fusion Source: UniProtKB
  • vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 7
Alternative name(s):
Synaptobrevin-like protein 1
Gene namesi
Name:VAMP7By similarity
Synonyms:SYBL1By similarity
ORF Names:RCJMB04_7f19
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 188187CytoplasmicSequence analysisBy similarityAdd
BLAST
Transmembranei189 – 20921Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini210 – 22011VesicularSequence analysisBy similarityAdd
BLAST

GO - Cellular componenti

  • apical part of cell Source: Ensembl
  • azurophil granule membrane Source: Ensembl
  • cell junction Source: UniProtKB-KW
  • cell surface Source: Ensembl
  • endoplasmic reticulum membrane Source: UniProtKB
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • lamellipodium Source: Ensembl
  • late endosome membrane Source: UniProtKB
  • lysosomal membrane Source: UniProtKB
  • neuron projection Source: UniProtKB
  • perinuclear region of cytoplasm Source: Ensembl
  • phagocytic vesicle Source: UniProtKB
  • phagocytic vesicle membrane Source: UniProtKB-SubCell
  • plasma membrane Source: Ensembl
  • platelet alpha granule Source: Ensembl
  • pseudopodium Source: Ensembl
  • SNARE complex Source: UniProtKB
  • synapse Source: UniProtKB-KW
  • trans-Golgi network Source: Ensembl
  • transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 220219Vesicle-associated membrane protein 7By similarityPRO_0000319995Add
BLAST

Proteomic databases

PaxDbiQ5ZL74.

Expressioni

Gene expression databases

BgeeiENSGALG00000007476.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012071.

Structurei

3D structure databases

ProteinModelPortaliQ5ZL74.
SMRiQ5ZL74. Positions 1-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 110104LonginPROSITE-ProRule annotationAdd
BLAST
Domaini125 – 18561v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Sequence analysis
Contains 1 longin domain.PROSITE-ProRule annotation
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0859. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00510000047733.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiQ5ZL74.
KOiK08515.
OMAiARSLFWK.
OrthoDBiEOG091G0MPE.
PhylomeDBiQ5ZL74.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
PRINTSiPR00219. SYNAPTOBREVN.
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZL74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILFAVVAR GTTILAKHAW CGGNFLEVTE QILAKIPSEN NKLTYSHGNY
60 70 80 90 100
LFHYICQDRI IYLCITDDDF ERSRAFNFLN EIKKRFQTTY GSRAQTALPY
110 120 130 140 150
AMNSEFSSVL AAQLKYHSES KGTDQVAETQ AQVDELKGIM VRNIDLVAQR
160 170 180 190 200
GEKLELLIDK TENLVDSSVT FKTTSRNLAR AMCMKNLKLT IIIIIVSIVI
210 220
IYIIVSAACG GLAWPSCVQK
Length:220
Mass (Da):24,682
Last modified:November 23, 2004 - v1
Checksum:iD08834367BD53CA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719860 mRNA. Translation: CAG31519.1.
RefSeqiNP_001026292.1. NM_001031121.1.
XP_015133771.1. XM_015278285.1.
XP_015133772.1. XM_015278286.1.
XP_015133773.1. XM_015278287.1.
XP_015133774.1. XM_015278288.1.
XP_015133775.1. XM_015278289.1.
UniGeneiGga.50742.

Genome annotation databases

EnsembliENSGALT00000032338; ENSGALP00000031702; ENSGALG00000007476.
GeneIDi422297.
KEGGigga:422297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719860 mRNA. Translation: CAG31519.1.
RefSeqiNP_001026292.1. NM_001031121.1.
XP_015133771.1. XM_015278285.1.
XP_015133772.1. XM_015278286.1.
XP_015133773.1. XM_015278287.1.
XP_015133774.1. XM_015278288.1.
XP_015133775.1. XM_015278289.1.
UniGeneiGga.50742.

3D structure databases

ProteinModelPortaliQ5ZL74.
SMRiQ5ZL74. Positions 1-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012071.

Proteomic databases

PaxDbiQ5ZL74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000032338; ENSGALP00000031702; ENSGALG00000007476.
GeneIDi422297.
KEGGigga:422297.

Organism-specific databases

CTDi6845.

Phylogenomic databases

eggNOGiKOG0859. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00510000047733.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiQ5ZL74.
KOiK08515.
OMAiARSLFWK.
OrthoDBiEOG091G0MPE.
PhylomeDBiQ5ZL74.

Miscellaneous databases

PROiQ5ZL74.

Gene expression databases

BgeeiENSGALG00000007476.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
PRINTSiPR00219. SYNAPTOBREVN.
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVAMP7_CHICK
AccessioniPrimary (citable) accession number: Q5ZL74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.