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Protein

Coatomer subunit delta

Gene

ARCN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-GGA-199997. COPI Mediated Transport.
R-GGA-6807878. COPI-mediated anterograde transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit delta
Alternative name(s):
Archain
Delta-coat protein
Short name:
Delta-COP
Gene namesi
Name:ARCN1
Synonyms:COPD
ORF Names:RCJMB04_7j3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Coatomer subunit deltaPRO_0000193845Add
BLAST

Proteomic databases

PaxDbiQ5ZL57.
PRIDEiQ5ZL57.

Expressioni

Gene expression databases

ExpressionAtlasiQ5ZL57. baseline.

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.By similarity

Protein-protein interaction databases

BioGridi691278. 2 interactions.
IntActiQ5ZL57. 1 interaction.
STRINGi9031.ENSGALP00000012007.

Structurei

3D structure databases

ProteinModelPortaliQ5ZL57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini270 – 510241MHDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2635. Eukaryota.
ENOG410XRH2. LUCA.
HOGENOMiHOG000203984.
HOVERGENiHBG005381.
InParanoidiQ5ZL57.
OrthoDBiEOG7CG6ZW.
PhylomeDBiQ5ZL57.
TreeFamiTF105760.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR027059. Coatomer_dsu.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PANTHERiPTHR10121. PTHR10121. 1 hit.
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS51072. MHD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZL57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE
60 70 80 90 100
TESVRYVYQP MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN
110 120 130 140 150
EISEHCFDLI FAFDEIVALG YRENVNLAQI RTFTEMDSHE EKVFRAVRET
160 170 180 190 200
QEREAKAEMR RKAKELQQAR RDAERLGKKA PGFGGFGSSA VSGGTTAAMI
210 220 230 240 250
TETIIETEKP KVAPAPSRPS GPSKALKLGA KGKEVDNFVD KLKSEGENIM
260 270 280 290 300
TSVGKRSTEA AKVLAPPINM ESVHMKIEEK ISLTCGRDGG LQNMELHGMI
310 320 330 340 350
MLHISDEKFA RIRLHVENED KRGVQLQTHP NVDKKLFTAE SQIGLKNPEK
360 370 380 390 400
SFPINSDVGV LKWRLQTTEE SFIPLTINCW PSESGNSCDV NIEYELQEES
410 420 430 440 450
LELNDVVIMI PLPSGVGAPV IGEIDGEYRH DSRRNLLEWC LPVIDAKNKS
460 470 480 490 500
GSLEFSIAGQ PNDFFPVQVS FISKKNYCNI QVTKVTQVDG NSPVRFSTET
510
TFLVDKYEIL
Length:510
Mass (Da):57,170
Last modified:November 23, 2004 - v1
Checksum:i5BD2C04CC5CE2C59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719877 mRNA. Translation: CAG31536.1.
RefSeqiNP_001072967.1. NM_001079499.1.
UniGeneiGga.1878.

Genome annotation databases

GeneIDi770561.
KEGGigga:770561.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719877 mRNA. Translation: CAG31536.1.
RefSeqiNP_001072967.1. NM_001079499.1.
UniGeneiGga.1878.

3D structure databases

ProteinModelPortaliQ5ZL57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi691278. 2 interactions.
IntActiQ5ZL57. 1 interaction.
STRINGi9031.ENSGALP00000012007.

Proteomic databases

PaxDbiQ5ZL57.
PRIDEiQ5ZL57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi770561.
KEGGigga:770561.

Organism-specific databases

CTDi372.

Phylogenomic databases

eggNOGiKOG2635. Eukaryota.
ENOG410XRH2. LUCA.
HOGENOMiHOG000203984.
HOVERGENiHBG005381.
InParanoidiQ5ZL57.
OrthoDBiEOG7CG6ZW.
PhylomeDBiQ5ZL57.
TreeFamiTF105760.

Enzyme and pathway databases

ReactomeiR-GGA-199997. COPI Mediated Transport.
R-GGA-6807878. COPI-mediated anterograde transport.

Miscellaneous databases

NextBioi20920779.
PROiQ5ZL57.

Gene expression databases

ExpressionAtlasiQ5ZL57. baseline.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR027059. Coatomer_dsu.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PANTHERiPTHR10121. PTHR10121. 1 hit.
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS51072. MHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiCOPD_CHICK
AccessioniPrimary (citable) accession number: Q5ZL57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: November 23, 2004
Last modified: February 17, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.