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Protein

Serine-threonine kinase receptor-associated protein

Gene

STRAP

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins are trapped in an inactive complex. The SMN complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-GGA-2173788 Downregulation of TGF-beta receptor signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-threonine kinase receptor-associated protein
Gene namesi
Name:STRAP
ORF Names:RCJMB04_7p19
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003137961 – 350Serine-threonine kinase receptor-associated proteinAdd BLAST350

Proteomic databases

PaxDbiQ5ZL33
PRIDEiQ5ZL33

Expressioni

Gene expression databases

BgeeiENSGALG00000013092

Interactioni

Subunit structurei

Part of the core SMN complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021343

Structurei

3D structure databases

ProteinModelPortaliQ5ZL33
SMRiQ5ZL33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 56WD 1Add BLAST45
Repeati57 – 96WD 2Add BLAST40
Repeati98 – 137WD 3Add BLAST40
Repeati141 – 179WD 4Add BLAST39
Repeati180 – 212WD 5Add BLAST33
Repeati221 – 262WD 6Add BLAST42
Repeati263 – 302WD 7Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat STRAP family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0278 Eukaryota
ENOG410XPJ4 LUCA
GeneTreeiENSGT00630000089849
HOGENOMiHOG000174258
HOVERGENiHBG055228
InParanoidiQ5ZL33
KOiK13137
OMAiMISACKD
OrthoDBiEOG091G0BY5
PhylomeDBiQ5ZL33
TreeFamiTF323287

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZL33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMRQTPLTC SGHTRPVVDL AFSGVTPYGY FLISACKDGK PMLRQGDTGD
60 70 80 90 100
WIGTFLGHKG AVWGATLNKD ATKAATAAAD FTAKVWDAVS GDELITLAHK
110 120 130 140 150
HIVKSVDFTQ DSNYLLTGGQ DKLLRIYDLS KPEAEPDVVS GHTSGIKKAL
160 170 180 190 200
WSSDDKQILS ADDKTVRLWD RSTMTEVKAL NVAMSVSSME YVPEGQILVI
210 220 230 240 250
TYGKTIAFHS AETLEQIKSF EAPATINSAS LHPEKECLVA GGEDFKLYKY
260 270 280 290 300
DYNTGEELES YKGHFGPIHC VRFSPDGELY ASGSEDGTLR LWQTTVGKTY
310 320 330 340 350
GLWKCVVPEE ENAEAAKART TLPGTAEEEI EEVASENSDS VYSSTPEVKA
Length:350
Mass (Da):38,141
Last modified:January 15, 2008 - v2
Checksum:iE13C2CF4D1B2B5D0
GO

Sequence cautioni

The sequence CAG31560 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719901 mRNA Translation: CAG31560.1 Different initiation.
RefSeqiNP_001006247.2, NM_001006247.2
UniGeneiGga.44357

Genome annotation databases

EnsembliENSGALT00000021374; ENSGALP00000021343; ENSGALG00000013092
GeneIDi418175
KEGGigga:418175

Similar proteinsi

Entry informationi

Entry nameiSTRAP_CHICK
AccessioniPrimary (citable) accession number: Q5ZL33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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