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Protein

Serine-threonine kinase receptor-associated protein

Gene

STRAP

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins are trapped in an inactive complex. The SMN complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-GGA-2173788. Downregulation of TGF-beta receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-threonine kinase receptor-associated protein
Gene namesi
Name:STRAP
ORF Names:RCJMB04_7p19
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Localized predominantly in the cytoplasm but also found in the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Serine-threonine kinase receptor-associated proteinPRO_0000313796Add
BLAST

Proteomic databases

PaxDbiQ5ZL33.
PRIDEiQ5ZL33.

Interactioni

Subunit structurei

Part of the core SMN complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021343.

Structurei

3D structure databases

ProteinModelPortaliQ5ZL33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati12 – 5645WD 1Add
BLAST
Repeati57 – 9640WD 2Add
BLAST
Repeati98 – 13740WD 3Add
BLAST
Repeati141 – 17939WD 4Add
BLAST
Repeati180 – 21233WD 5Add
BLAST
Repeati221 – 26242WD 6Add
BLAST
Repeati263 – 30240WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat STRAP family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0278. Eukaryota.
ENOG410XPJ4. LUCA.
GeneTreeiENSGT00630000089849.
HOGENOMiHOG000174258.
HOVERGENiHBG055228.
InParanoidiQ5ZL33.
KOiK13137.
OMAiHGPIWSI.
OrthoDBiEOG7288RQ.
PhylomeDBiQ5ZL33.
TreeFamiTF323287.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZL33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMRQTPLTC SGHTRPVVDL AFSGVTPYGY FLISACKDGK PMLRQGDTGD
60 70 80 90 100
WIGTFLGHKG AVWGATLNKD ATKAATAAAD FTAKVWDAVS GDELITLAHK
110 120 130 140 150
HIVKSVDFTQ DSNYLLTGGQ DKLLRIYDLS KPEAEPDVVS GHTSGIKKAL
160 170 180 190 200
WSSDDKQILS ADDKTVRLWD RSTMTEVKAL NVAMSVSSME YVPEGQILVI
210 220 230 240 250
TYGKTIAFHS AETLEQIKSF EAPATINSAS LHPEKECLVA GGEDFKLYKY
260 270 280 290 300
DYNTGEELES YKGHFGPIHC VRFSPDGELY ASGSEDGTLR LWQTTVGKTY
310 320 330 340 350
GLWKCVVPEE ENAEAAKART TLPGTAEEEI EEVASENSDS VYSSTPEVKA
Length:350
Mass (Da):38,141
Last modified:January 15, 2008 - v2
Checksum:iE13C2CF4D1B2B5D0
GO

Sequence cautioni

The sequence CAG31560.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719901 mRNA. Translation: CAG31560.1. Different initiation.
RefSeqiNP_001006247.2. NM_001006247.2.
UniGeneiGga.44357.

Genome annotation databases

EnsembliENSGALT00000021374; ENSGALP00000021343; ENSGALG00000013092.
GeneIDi418175.
KEGGigga:418175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719901 mRNA. Translation: CAG31560.1. Different initiation.
RefSeqiNP_001006247.2. NM_001006247.2.
UniGeneiGga.44357.

3D structure databases

ProteinModelPortaliQ5ZL33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021343.

Proteomic databases

PaxDbiQ5ZL33.
PRIDEiQ5ZL33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000021374; ENSGALP00000021343; ENSGALG00000013092.
GeneIDi418175.
KEGGigga:418175.

Organism-specific databases

CTDi11171.

Phylogenomic databases

eggNOGiKOG0278. Eukaryota.
ENOG410XPJ4. LUCA.
GeneTreeiENSGT00630000089849.
HOGENOMiHOG000174258.
HOVERGENiHBG055228.
InParanoidiQ5ZL33.
KOiK13137.
OMAiHGPIWSI.
OrthoDBiEOG7288RQ.
PhylomeDBiQ5ZL33.
TreeFamiTF323287.

Enzyme and pathway databases

ReactomeiR-GGA-2173788. Downregulation of TGF-beta receptor signaling.

Miscellaneous databases

PROiQ5ZL33.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiSTRAP_CHICK
AccessioniPrimary (citable) accession number: Q5ZL33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 8, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.