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Protein

Kinesin-like protein KIF2A

Gene

KIF2A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi313 – 3208ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Differentiation, Mitosis, Neurogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF2A
Gene namesi
Name:KIF2ABy similarity
ORF Names:RCJMB04_9a7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Kinesin-like protein KIF2APRO_0000306274Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5ZKV8.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023720.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKV8.
SMRiQ5ZKV8. Positions 196-550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini223 – 553331Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili154 – 18734Sequence analysisAdd
BLAST
Coiled coili662 – 69938Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0246. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000231329.
HOVERGENiHBG003875.
InParanoidiQ5ZKV8.
KOiK10393.
PhylomeDBiQ5ZKV8.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZKV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAANFGKIQ IGIYVEIKRS DGRIHQAMVT SLNEDNESVT VEWIENGDTK
60 70 80 90 100
GKEIDLESIF SLNPDLAPDE DIEPSPETQP LPAPSAKVNK IVKGRRTVAP
110 120 130 140 150
VKNDTPARDN RVASSARARP TQLPEQSSSS QQNGTVSGIS PVQAAKKEFG
160 170 180 190 200
PPSRRKSNCV KEVEKLQEKR EKRRLQQQEL REKRAQDVDA TNPNYEIMCM
210 220 230 240 250
IRDFRGNLDY RPLTTADPID EHRICVCVRK RPLNRKETLM KDLDVITIPS
260 270 280 290 300
KDVVMVHEPK QKVDLTRYLE NQTFRFDYAF DETAPNEMVY RFTARPLVET
310 320 330 340 350
IFERGMATCF AYGQTGSGKT HTMGGDFSGK NQDCSKGIYA LAARDVFLML
360 370 380 390 400
KKPNYKKLEL QVYATFFEIY SGKVFDLLNR KTKLRVLEDG KQQVQVVGLQ
410 420 430 440 450
EREVKCVEDV LKLIEIGNSC RTSGQTSANA HSSRSHAVFQ IILRRKGKLH
460 470 480 490 500
GKFSLIDLAG NERGADTSSA DRQTRLEGAE INKSLLALKE CIRALGRNKP
510 520 530 540 550
HTPFRASKLT QVLRDSFIGE NSRTCMIATI SPGMASCENT LNTLRYANRV
560 570 580 590 600
KELTIDPSAA GDIRPIIHHT PSQIDDLDTQ WGVGSSPQRD DLKLLCEQNE
610 620 630 640 650
EEVSPQLFTF HEAVSQMVEM EEQVVEDHRT VFQESIRWLE DEKALLEMTE
660 670 680 690 700
EVDYDVDSYA TQLEAILDQK IDILTELRDK VKSFRAALQE EEQASKQINP

KRPRAV
Length:706
Mass (Da):79,864
Last modified:October 2, 2007 - v2
Checksum:i6C5CA4DAE3DA1EC8
GO

Sequence cautioni

The sequence CAG31635.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719976 mRNA. Translation: CAG31635.1. Different initiation.
RefSeqiNP_001034401.2. NM_001039312.2.
UniGeneiGga.2067.

Genome annotation databases

GeneIDi427156.
KEGGigga:427156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719976 mRNA. Translation: CAG31635.1. Different initiation.
RefSeqiNP_001034401.2. NM_001039312.2.
UniGeneiGga.2067.

3D structure databases

ProteinModelPortaliQ5ZKV8.
SMRiQ5ZKV8. Positions 196-550.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023720.

Proteomic databases

PaxDbiQ5ZKV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi427156.
KEGGigga:427156.

Organism-specific databases

CTDi3796.

Phylogenomic databases

eggNOGiKOG0246. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000231329.
HOVERGENiHBG003875.
InParanoidiQ5ZKV8.
KOiK10393.
PhylomeDBiQ5ZKV8.

Miscellaneous databases

PROiQ5ZKV8.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CBImported.
    Tissue: Bursa of FabriciusImported.

Entry informationi

Entry nameiKIF2A_CHICK
AccessioniPrimary (citable) accession number: Q5ZKV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 8, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.