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Protein

Cytosolic Fe-S cluster assembly factor NUBP2

Gene

NUBP2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi197 – 1971Iron-sulfur (4Fe-4S); shared with dimeric partnerUniRule annotation
Metal bindingi200 – 2001Iron-sulfur (4Fe-4S); shared with dimeric partnerUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 308ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

4Fe-4S, ATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic Fe-S cluster assembly factor NUBP2UniRule annotation
Alternative name(s):
Nucleotide-binding protein 2UniRule annotation
Short name:
NBP 2UniRule annotation
Gene namesi
Name:NUBP2UniRule annotationBy similarity
ORF Names:RCJMB04_9a23
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 14

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Cytosolic Fe-S cluster assembly factor NUBP2PRO_0000306171Add
BLAST

Proteomic databases

PaxDbiQ5ZKV4.
PRIDEiQ5ZKV4.

Interactioni

Subunit structurei

Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.UniRule annotation

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003634.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410KCSJ. Eukaryota.
COG0489. LUCA.
GeneTreeiENSGT00550000075057.
HOGENOMiHOG000079916.
HOVERGENiHBG051027.
InParanoidiQ5ZKV4.
OMAiEERNADT.
OrthoDBiEOG7D59NZ.
PhylomeDBiQ5ZKV4.
TreeFamiTF354321.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_02040. Mrp_NBP35.
MF_03039. NUBP2.
InterProiIPR019591. Mrp/NBP35_ATP-bd.
IPR000808. Mrp_CS.
IPR028600. NUBP2/Cfd1_eukaryotes.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23264. PTHR23264. 1 hit.
PfamiPF10609. ParA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01215. MRP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZKV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEVVAERSN LGGVRHILLV LSGKGGVGKS TISTELALSL RHSGKKVGIL
60 70 80 90 100
DVDLCGPSIP RMFKVQDNDV HQCDAGWVPV FVDQEKSISL MSIGFLLEKP
110 120 130 140 150
DDAVVWRGPK KNALIKQFVA DVAWGELDFL IVDTPPGTSD EHISTVEALR
160 170 180 190 200
PYKPLGAILV TTPQAVSVGD VRRELTFCKK TGLRVLGIVE NMSGFVCPHC
210 220 230 240 250
SECTNIFSKG GGEELAKHAG VPFLGSVPLD PQLSQSLEEG RDFIQEFPKS
260 270
SAFPALTRIA QQILDGALQR SS
Length:272
Mass (Da):29,359
Last modified:November 23, 2004 - v1
Checksum:i93FB0189D8DF3A5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719980 mRNA. Translation: CAG31639.1.
RefSeqiNP_001007834.1. NM_001007833.2.
UniGeneiGga.4676.

Genome annotation databases

EnsembliENSGALT00000003641; ENSGALP00000003634; ENSGALG00000002316.
GeneIDi416402.
KEGGigga:416402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719980 mRNA. Translation: CAG31639.1.
RefSeqiNP_001007834.1. NM_001007833.2.
UniGeneiGga.4676.

3D structure databases

ProteinModelPortaliQ5ZKV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003634.

Proteomic databases

PaxDbiQ5ZKV4.
PRIDEiQ5ZKV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000003641; ENSGALP00000003634; ENSGALG00000002316.
GeneIDi416402.
KEGGigga:416402.

Organism-specific databases

CTDi10101.

Phylogenomic databases

eggNOGiENOG410KCSJ. Eukaryota.
COG0489. LUCA.
GeneTreeiENSGT00550000075057.
HOGENOMiHOG000079916.
HOVERGENiHBG051027.
InParanoidiQ5ZKV4.
OMAiEERNADT.
OrthoDBiEOG7D59NZ.
PhylomeDBiQ5ZKV4.
TreeFamiTF354321.

Miscellaneous databases

NextBioi20819865.
PROiQ5ZKV4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_02040. Mrp_NBP35.
MF_03039. NUBP2.
InterProiIPR019591. Mrp/NBP35_ATP-bd.
IPR000808. Mrp_CS.
IPR028600. NUBP2/Cfd1_eukaryotes.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23264. PTHR23264. 1 hit.
PfamiPF10609. ParA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01215. MRP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CBImported.
    Tissue: Bursa of FabriciusImported.

Entry informationi

Entry nameiNUBP2_CHICK
AccessioniPrimary (citable) accession number: Q5ZKV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 23, 2004
Last modified: December 9, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.