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Protein

Long-chain-fatty-acid--CoA ligase ACSBG2

Gene

ACSBG2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei550 – 5501ATPBy similarity
Binding sitei565 – 5651ATPBy similarity
Binding sitei678 – 6781ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi281 – 2899ATPBy similarity
Nucleotide bindingi472 – 4776ATPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2
Gene namesi
Name:ACSBG2
ORF Names:RCJMB04_9i11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Long-chain-fatty-acid--CoA ligase ACSBG2PRO_0000315815Add
BLAST

Proteomic databases

PaxDbiQ5ZKR7.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002679.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
HOGENOMiHOG000230004.
HOVERGENiHBG054660.
InParanoidiQ5ZKR7.
PhylomeDBiQ5ZKR7.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZKR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCESEARST LADPVPMAYL SVDAQGSSEV SLDDITINSS AGTVEVCSMK
60 70 80 90 100
PADDPKTERS QMNKTGLASS SRPASNVWTT QQDGEVKLRM DEEGMGSEAP
110 120 130 140 150
KTVHEVFQEA VSKYGDYYAL ASKKNGQWVK LTYKMYYDKC WKAAKSFLKL
160 170 180 190 200
VLERFHGVCI LGFNSPEWFI ADIGAIFAGG LAVGIYTTNS PEACHYVAEN
210 220 230 240 250
CSANILVVEN HTQACRKSLE IEHKLPHMKA IIQYGEELKE KRPNQYSWRE
260 270 280 290 300
FLDLGEDIPD SQLREIIESQ KPNQCCTLIY TSGTTGQPKG VMLSHDNLTW
310 320 330 340 350
TSIAAGRSLM LLEATEKQEL VVSYLPLSHV AAQMIDIWLP VTFGGQVFFA
360 370 380 390 400
QPDALKGTLV DTLREVRPTA FLGVPRVWEK IEEKMKSVGA KSSTLRRKVA
410 420 430 440 450
SWAKGVGLQT NLKWMNGHSE VPMNFRLARQ LVYKKVRKAI GLDRCTKCFT
460 470 480 490 500
GAAPISRETL EFFLSLNIPV FELYGMSESS GPHTVSIPQA FRLTSCGKEM
510 520 530 540 550
AGCRTLIHKP DADGIGEICF AGRHIFMGYL NMEEKTKEAI DKDGWLHSGD
560 570 580 590 600
LGKCDKDGFI YITGRIKELI ITAGGENVPP VPIEDAVKEA CPIISNAMLV
610 620 630 640 650
GDKAKFLAML LTLKCIINTE SGEPGDDLTA EAIEYCQKLG SKATKVSEII
660 670 680 690 700
SSKDKAVYAA IQAAVSEVNK RAVSNAQKIQ KWVVLEKDFS VGGGELGPTM
710 720 730 740 750
KLKRPVVAQK YKDLIDEFYA DANTPTTTEE RTSAVMWGGR KLPLVHSIVS
760
LGSLQQIQRV LQK
Length:763
Mass (Da):84,207
Last modified:January 15, 2008 - v2
Checksum:i01B065BA33BCAB43
GO

Sequence cautioni

The sequence CAG31676.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720017 mRNA. Translation: CAG31676.1. Different initiation.
UniGeneiGga.22498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720017 mRNA. Translation: CAG31676.1. Different initiation.
UniGeneiGga.22498.

3D structure databases

ProteinModelPortaliQ5ZKR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002679.

Proteomic databases

PaxDbiQ5ZKR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG1022.
HOGENOMiHOG000230004.
HOVERGENiHBG054660.
InParanoidiQ5ZKR7.
PhylomeDBiQ5ZKR7.

Miscellaneous databases

NextBioi20823052.
PROiQ5ZKR7.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiACBG2_CHICK
AccessioniPrimary (citable) accession number: Q5ZKR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 22, 2015
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.