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Q5ZKR7

- ACBG2_CHICK

UniProt

Q5ZKR7 - ACBG2_CHICK

Protein

Long-chain-fatty-acid--CoA ligase ACSBG2

Gene

ACSBG2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei550 – 5501ATPBy similarity
    Binding sitei565 – 5651ATPBy similarity
    Binding sitei678 – 6781ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi281 – 2899ATPBy similarity
    Nucleotide bindingi472 – 4776ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase ACSBG2 (EC:6.2.1.3)
    Alternative name(s):
    Acyl-CoA synthetase bubblegum family member 2
    Gene namesi
    Name:ACSBG2
    ORF Names:RCJMB04_9i11
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 763763Long-chain-fatty-acid--CoA ligase ACSBG2PRO_0000315815Add
    BLAST

    Proteomic databases

    PaxDbiQ5ZKR7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000002679.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZKR7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1022.
    HOGENOMiHOG000230004.
    HOVERGENiHBG054660.
    InParanoidiQ5ZKR7.
    KOiK15013.
    PhylomeDBiQ5ZKR7.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5ZKR7-1 [UniParc]FASTAAdd to Basket

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    MLCESEARST LADPVPMAYL SVDAQGSSEV SLDDITINSS AGTVEVCSMK    50
    PADDPKTERS QMNKTGLASS SRPASNVWTT QQDGEVKLRM DEEGMGSEAP 100
    KTVHEVFQEA VSKYGDYYAL ASKKNGQWVK LTYKMYYDKC WKAAKSFLKL 150
    VLERFHGVCI LGFNSPEWFI ADIGAIFAGG LAVGIYTTNS PEACHYVAEN 200
    CSANILVVEN HTQACRKSLE IEHKLPHMKA IIQYGEELKE KRPNQYSWRE 250
    FLDLGEDIPD SQLREIIESQ KPNQCCTLIY TSGTTGQPKG VMLSHDNLTW 300
    TSIAAGRSLM LLEATEKQEL VVSYLPLSHV AAQMIDIWLP VTFGGQVFFA 350
    QPDALKGTLV DTLREVRPTA FLGVPRVWEK IEEKMKSVGA KSSTLRRKVA 400
    SWAKGVGLQT NLKWMNGHSE VPMNFRLARQ LVYKKVRKAI GLDRCTKCFT 450
    GAAPISRETL EFFLSLNIPV FELYGMSESS GPHTVSIPQA FRLTSCGKEM 500
    AGCRTLIHKP DADGIGEICF AGRHIFMGYL NMEEKTKEAI DKDGWLHSGD 550
    LGKCDKDGFI YITGRIKELI ITAGGENVPP VPIEDAVKEA CPIISNAMLV 600
    GDKAKFLAML LTLKCIINTE SGEPGDDLTA EAIEYCQKLG SKATKVSEII 650
    SSKDKAVYAA IQAAVSEVNK RAVSNAQKIQ KWVVLEKDFS VGGGELGPTM 700
    KLKRPVVAQK YKDLIDEFYA DANTPTTTEE RTSAVMWGGR KLPLVHSIVS 750
    LGSLQQIQRV LQK 763
    Length:763
    Mass (Da):84,207
    Last modified:January 15, 2008 - v2
    Checksum:i01B065BA33BCAB43
    GO

    Sequence cautioni

    The sequence CAG31676.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720017 mRNA. Translation: CAG31676.1. Different initiation.
    RefSeqiNP_001012864.1. NM_001012846.1.
    UniGeneiGga.22498.

    Genome annotation databases

    GeneIDi420090.
    KEGGigga:420090.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720017 mRNA. Translation: CAG31676.1 . Different initiation.
    RefSeqi NP_001012864.1. NM_001012846.1.
    UniGenei Gga.22498.

    3D structure databases

    ProteinModelPortali Q5ZKR7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000002679.

    Proteomic databases

    PaxDbi Q5ZKR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 420090.
    KEGGi gga:420090.

    Organism-specific databases

    CTDi 81616.

    Phylogenomic databases

    eggNOGi COG1022.
    HOGENOMi HOG000230004.
    HOVERGENi HBG054660.
    InParanoidi Q5ZKR7.
    KOi K15013.
    PhylomeDBi Q5ZKR7.

    Miscellaneous databases

    NextBioi 20823052.
    PROi Q5ZKR7.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiACBG2_CHICK
    AccessioniPrimary (citable) accession number: Q5ZKR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 62 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3