Q5ZKR7 (ACBG2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2
EC=6.2.1.3

Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2

Gene names

Name:	ACSBG2
ORF Names:	RCJMB04_9i11

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	763 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation By similarity.
Catalytic activity	ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.
Sequence caution	The sequence CAG31676.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW long-chain fatty acid-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 763	763	Long-chain-fatty-acid--CoA ligase ACSBG2		PRO_0000315815
Regions
	Nucleotide binding	281 – 289	9	ATP By similarity
	Nucleotide binding	472 – 477	6	ATP By similarity
Sites
	Binding site	550	1	ATP By similarity
	Binding site	565	1	ATP By similarity
	Binding site	678	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZKR7 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 01B065BA33BCAB43	FASTA	763	84,207
	10 20 30 40 50 60 MLCESEARST LADPVPMAYL SVDAQGSSEV SLDDITINSS AGTVEVCSMK PADDPKTERS 70 80 90 100 110 120 QMNKTGLASS SRPASNVWTT QQDGEVKLRM DEEGMGSEAP KTVHEVFQEA VSKYGDYYAL 130 140 150 160 170 180 ASKKNGQWVK LTYKMYYDKC WKAAKSFLKL VLERFHGVCI LGFNSPEWFI ADIGAIFAGG 190 200 210 220 230 240 LAVGIYTTNS PEACHYVAEN CSANILVVEN HTQACRKSLE IEHKLPHMKA IIQYGEELKE 250 260 270 280 290 300 KRPNQYSWRE FLDLGEDIPD SQLREIIESQ KPNQCCTLIY TSGTTGQPKG VMLSHDNLTW 310 320 330 340 350 360 TSIAAGRSLM LLEATEKQEL VVSYLPLSHV AAQMIDIWLP VTFGGQVFFA QPDALKGTLV 370 380 390 400 410 420 DTLREVRPTA FLGVPRVWEK IEEKMKSVGA KSSTLRRKVA SWAKGVGLQT NLKWMNGHSE 430 440 450 460 470 480 VPMNFRLARQ LVYKKVRKAI GLDRCTKCFT GAAPISRETL EFFLSLNIPV FELYGMSESS 490 500 510 520 530 540 GPHTVSIPQA FRLTSCGKEM AGCRTLIHKP DADGIGEICF AGRHIFMGYL NMEEKTKEAI 550 560 570 580 590 600 DKDGWLHSGD LGKCDKDGFI YITGRIKELI ITAGGENVPP VPIEDAVKEA CPIISNAMLV 610 620 630 640 650 660 GDKAKFLAML LTLKCIINTE SGEPGDDLTA EAIEYCQKLG SKATKVSEII SSKDKAVYAA 670 680 690 700 710 720 IQAAVSEVNK RAVSNAQKIQ KWVVLEKDFS VGGGELGPTM KLKRPVVAQK YKDLIDEFYA 730 740 750 760 DANTPTTTEE RTSAVMWGGR KLPLVHSIVS LGSLQQIQRV LQK

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ720017 mRNA. Translation: CAG31676.1. Different initiation.
IPI	IPI00592307.
RefSeq	NP_001012864.1. NM_001012846.1.
UniGene	Gga.22498.
3D structure databases
ProteinModelPortal	Q5ZKR7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	420090.
KEGG	gga:420090.
Organism-specific databases
CTD	81616.
Phylogenomic databases
eggNOG	veNOG04901.
GeneTree	ENSGT00600000084439.
HOGENOM	HBG721674.
HOVERGEN	HBG054660.
InParanoid	Q5ZKR7.
OrthoDB	EOG43R3MF.
Family and domain databases
InterPro	IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K15013.
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACBG2_CHICK

Accession

Primary (citable) accession number: Q5ZKR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	November 16, 2011
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program