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Q5ZKR7 (ACBG2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2

EC=6.2.1.3
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2
Gene names
Name:ACSBG2
ORF Names:RCJMB04_9i11
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length763 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.

Sequence caution

The sequence CAG31676.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

long-chain fatty acid-CoA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 763763Long-chain-fatty-acid--CoA ligase ACSBG2
PRO_0000315815

Regions

Nucleotide binding281 – 2899ATP By similarity
Nucleotide binding472 – 4776ATP By similarity

Sites

Binding site5501ATP By similarity
Binding site5651ATP By similarity
Binding site6781ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZKR7 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 01B065BA33BCAB43

FASTA76384,207
        10         20         30         40         50         60 
MLCESEARST LADPVPMAYL SVDAQGSSEV SLDDITINSS AGTVEVCSMK PADDPKTERS 

        70         80         90        100        110        120 
QMNKTGLASS SRPASNVWTT QQDGEVKLRM DEEGMGSEAP KTVHEVFQEA VSKYGDYYAL 

       130        140        150        160        170        180 
ASKKNGQWVK LTYKMYYDKC WKAAKSFLKL VLERFHGVCI LGFNSPEWFI ADIGAIFAGG 

       190        200        210        220        230        240 
LAVGIYTTNS PEACHYVAEN CSANILVVEN HTQACRKSLE IEHKLPHMKA IIQYGEELKE 

       250        260        270        280        290        300 
KRPNQYSWRE FLDLGEDIPD SQLREIIESQ KPNQCCTLIY TSGTTGQPKG VMLSHDNLTW 

       310        320        330        340        350        360 
TSIAAGRSLM LLEATEKQEL VVSYLPLSHV AAQMIDIWLP VTFGGQVFFA QPDALKGTLV 

       370        380        390        400        410        420 
DTLREVRPTA FLGVPRVWEK IEEKMKSVGA KSSTLRRKVA SWAKGVGLQT NLKWMNGHSE 

       430        440        450        460        470        480 
VPMNFRLARQ LVYKKVRKAI GLDRCTKCFT GAAPISRETL EFFLSLNIPV FELYGMSESS 

       490        500        510        520        530        540 
GPHTVSIPQA FRLTSCGKEM AGCRTLIHKP DADGIGEICF AGRHIFMGYL NMEEKTKEAI 

       550        560        570        580        590        600 
DKDGWLHSGD LGKCDKDGFI YITGRIKELI ITAGGENVPP VPIEDAVKEA CPIISNAMLV 

       610        620        630        640        650        660 
GDKAKFLAML LTLKCIINTE SGEPGDDLTA EAIEYCQKLG SKATKVSEII SSKDKAVYAA 

       670        680        690        700        710        720 
IQAAVSEVNK RAVSNAQKIQ KWVVLEKDFS VGGGELGPTM KLKRPVVAQK YKDLIDEFYA 

       730        740        750        760 
DANTPTTTEE RTSAVMWGGR KLPLVHSIVS LGSLQQIQRV LQK 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ720017 mRNA. Translation: CAG31676.1. Different initiation.
RefSeqNP_001012864.1. NM_001012846.1.
UniGeneGga.22498.

3D structure databases

ProteinModelPortalQ5ZKR7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000002679.

Proteomic databases

PaxDbQ5ZKR7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID420090.
KEGGgga:420090.

Organism-specific databases

CTD81616.

Phylogenomic databases

eggNOGCOG1022.
HOGENOMHOG000230004.
HOVERGENHBG054660.
InParanoidQ5ZKR7.
KOK15013.
PhylomeDBQ5ZKR7.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20823052.
PROQ5ZKR7.

Entry information

Entry nameACBG2_CHICK
AccessionPrimary (citable) accession number: Q5ZKR7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families