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Q5ZKR7

- ACBG2_CHICK

UniProt

Q5ZKR7 - ACBG2_CHICK

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Protein
Long-chain-fatty-acid--CoA ligase ACSBG2
Gene
ACSBG2, RCJMB04_9i11
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation By similarity.

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei550 – 5501ATP By similarity
Binding sitei565 – 5651ATP By similarity
Binding sitei678 – 6781ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi281 – 2899ATP By similarity
Nucleotide bindingi472 – 4776ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2
Gene namesi
Name:ACSBG2
ORF Names:RCJMB04_9i11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Long-chain-fatty-acid--CoA ligase ACSBG2
PRO_0000315815Add
BLAST

Proteomic databases

PaxDbiQ5ZKR7.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002679.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKR7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
HOGENOMiHOG000230004.
HOVERGENiHBG054660.
InParanoidiQ5ZKR7.
KOiK15013.
PhylomeDBiQ5ZKR7.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZKR7-1 [UniParc]FASTAAdd to Basket

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MLCESEARST LADPVPMAYL SVDAQGSSEV SLDDITINSS AGTVEVCSMK    50
PADDPKTERS QMNKTGLASS SRPASNVWTT QQDGEVKLRM DEEGMGSEAP 100
KTVHEVFQEA VSKYGDYYAL ASKKNGQWVK LTYKMYYDKC WKAAKSFLKL 150
VLERFHGVCI LGFNSPEWFI ADIGAIFAGG LAVGIYTTNS PEACHYVAEN 200
CSANILVVEN HTQACRKSLE IEHKLPHMKA IIQYGEELKE KRPNQYSWRE 250
FLDLGEDIPD SQLREIIESQ KPNQCCTLIY TSGTTGQPKG VMLSHDNLTW 300
TSIAAGRSLM LLEATEKQEL VVSYLPLSHV AAQMIDIWLP VTFGGQVFFA 350
QPDALKGTLV DTLREVRPTA FLGVPRVWEK IEEKMKSVGA KSSTLRRKVA 400
SWAKGVGLQT NLKWMNGHSE VPMNFRLARQ LVYKKVRKAI GLDRCTKCFT 450
GAAPISRETL EFFLSLNIPV FELYGMSESS GPHTVSIPQA FRLTSCGKEM 500
AGCRTLIHKP DADGIGEICF AGRHIFMGYL NMEEKTKEAI DKDGWLHSGD 550
LGKCDKDGFI YITGRIKELI ITAGGENVPP VPIEDAVKEA CPIISNAMLV 600
GDKAKFLAML LTLKCIINTE SGEPGDDLTA EAIEYCQKLG SKATKVSEII 650
SSKDKAVYAA IQAAVSEVNK RAVSNAQKIQ KWVVLEKDFS VGGGELGPTM 700
KLKRPVVAQK YKDLIDEFYA DANTPTTTEE RTSAVMWGGR KLPLVHSIVS 750
LGSLQQIQRV LQK 763
Length:763
Mass (Da):84,207
Last modified:January 15, 2008 - v2
Checksum:i01B065BA33BCAB43
GO

Sequence cautioni

The sequence CAG31676.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720017 mRNA. Translation: CAG31676.1. Different initiation.
RefSeqiNP_001012864.1. NM_001012846.1.
UniGeneiGga.22498.

Genome annotation databases

GeneIDi420090.
KEGGigga:420090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720017 mRNA. Translation: CAG31676.1 . Different initiation.
RefSeqi NP_001012864.1. NM_001012846.1.
UniGenei Gga.22498.

3D structure databases

ProteinModelPortali Q5ZKR7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000002679.

Proteomic databases

PaxDbi Q5ZKR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 420090.
KEGGi gga:420090.

Organism-specific databases

CTDi 81616.

Phylogenomic databases

eggNOGi COG1022.
HOGENOMi HOG000230004.
HOVERGENi HBG054660.
InParanoidi Q5ZKR7.
KOi K15013.
PhylomeDBi Q5ZKR7.

Miscellaneous databases

NextBioi 20823052.
PROi Q5ZKR7.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiACBG2_CHICK
AccessioniPrimary (citable) accession number: Q5ZKR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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