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Protein

ADP-ribosylation factor-like protein 8A

Gene

ARL8A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 357GTPBy similarity
Nucleotide bindingi71 – 755GTPBy similarity
Nucleotide bindingi130 – 1334GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 8A
Gene namesi
Name:ARL8A
ORF Names:RCJMB04_9k9
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei1 – 1919Note=Mediates targeting to membranesBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186ADP-ribosylation factor-like protein 8APRO_0000232918Add
BLAST

Proteomic databases

PaxDbiQ5ZKQ8.
PRIDEiQ5ZKQ8.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000040104.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKQ8.
SMRiQ5ZKQ8. Positions 18-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0075. Eukaryota.
ENOG410XNUK. LUCA.
HOGENOMiHOG000163692.
HOVERGENiHBG105214.
InParanoidiQ5ZKQ8.
KOiK07955.
PhylomeDBiQ5ZKQ8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZKQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALFNKLLD WFRALFWKEE MELTLVGLQY SGKTTFVNVI ASGQFNEDMI
60 70 80 90 100
PTVGFNMRKI TKGNVTIKLW DIGGQPRFRS MWERYCRGVS AIVYMVDAAD
110 120 130 140 150
QEKIEASKNE LHNLLDKPQL QGIPVLVLGN KRDLPGALDE KELIEKMNLS
160 170 180
AIQDREICCY SISCKEKDNI DITLQWLIQH SKSRRS
Length:186
Mass (Da):21,444
Last modified:November 23, 2004 - v1
Checksum:i607B8BB7B32E6E75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720026 mRNA. Translation: CAG31685.1.
RefSeqiNP_001012886.1. NM_001012868.2.
UniGeneiGga.20429.

Genome annotation databases

GeneIDi421175.
KEGGigga:421175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720026 mRNA. Translation: CAG31685.1.
RefSeqiNP_001012886.1. NM_001012868.2.
UniGeneiGga.20429.

3D structure databases

ProteinModelPortaliQ5ZKQ8.
SMRiQ5ZKQ8. Positions 18-182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000040104.

Proteomic databases

PaxDbiQ5ZKQ8.
PRIDEiQ5ZKQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi421175.
KEGGigga:421175.

Organism-specific databases

CTDi127829.

Phylogenomic databases

eggNOGiKOG0075. Eukaryota.
ENOG410XNUK. LUCA.
HOGENOMiHOG000163692.
HOVERGENiHBG105214.
InParanoidiQ5ZKQ8.
KOiK07955.
PhylomeDBiQ5ZKQ8.

Miscellaneous databases

NextBioi20823988.
PROiQ5ZKQ8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiARL8A_CHICK
AccessioniPrimary (citable) accession number: Q5ZKQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.