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Q5ZKP6 (ADA_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase
EC=3.5.4.4
Alternative name(s):
Adenosine aminohydrolase
Gene names
Name:ADA
ORF Names:RCJMB04_9m8
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation By similarity.

Catalytic activity

Adenosine + H2O = inosine + NH3.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein; Extracellular side By similarity. Cell junction By similarity. Cytoplasmic vesicle lumen By similarity. Cytoplasm By similarity.

Sequence similarities

Belongs to the adenosine and AMP deaminases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Adenosine deaminase
PRO_0000194355

Sites

Active site2151Proton donor By similarity
Metal binding161Zinc; catalytic By similarity
Metal binding181Zinc; catalytic By similarity
Metal binding2121Zinc; catalytic By similarity
Metal binding2941Zinc; catalytic By similarity
Binding site181Substrate By similarity
Binding site201Substrate By similarity
Binding site1851Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site2951Substrate By similarity
Site2361Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZKP6 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 207806303E3FD54E

FASTA35740,679
        10         20         30         40         50         60 
MERGVRVFGE PKVELHIHLD GAIRPETILH FGKKRGVPLP GSTVDELMKH VSYQTPLSLK 

        70         80         90        100        110        120 
LFLEKFNHYM PAIAGDREAV RRIAYELVET KAKEGVVYVE VRYSPHLLAN CRVEPIPWGQ 

       130        140        150        160        170        180 
AEGDLTPEEV VNLVNQGLQD GERNFRIKAR SILCCMRHMP SWSPEVVELC KKYQNNSVVA 

       190        200        210        220        230        240 
IDLAGDELLM ASSDHKAAYE EAERCGIHRT VHAGEAGPAT MIKEAVYLLK AERIGHGYHV 

       250        260        270        280        290        300 
LEDPELYREL LRTRMHFEVC PWSSYLTGAC LPDFRKHPVV QFKKDQANYS INTDDPLIFN 

       310        320        330        340        350 
SNIDKDYGIV KEYMDFTEED FKRVNINAAQ SSFLPEKEKQ ELLNTLYEAY GMVPATS

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ720038 mRNA. Translation: CAG31697.1.
IPIIPI00588756.
RefSeqNP_001006290.1. NM_001006290.1.
UniGeneGga.9054.

3D structure databases

ProteinModelPortalQ5ZKP6.
SMRQ5ZKP6. Positions 8-352.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5ZKP6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID419194.
KEGGgga:419194.

Organism-specific databases

CTD100.

Phylogenomic databases

eggNOGveNOG04306.
GeneTreeENSGT00510000047600.
HOGENOMHBG630382.
HOVERGENHBG001718.
InParanoidQ5ZKP6.
OrthoDBEOG40K808.
PhylomeDBQ5ZKP6.

Family and domain databases

InterProIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADA_CHICK
AccessionPrimary (citable) accession number: Q5ZKP6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 23, 2004
Last modified: December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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