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Protein

Cyclin-dependent kinase 9

Gene

CDK9

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei48ATPPROSITE-ProRule annotation1
Active sitei149Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi25 – 33ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-112382. Formation of RNA Pol II elongation complex.
R-GGA-112387. Elongation arrest and recovery.
R-GGA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-GGA-674695. RNA Polymerase II Pre-transcription Events.
R-GGA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-GGA-6807505. RNA polymerase II transcribes snRNA genes.
R-GGA-75955. RNA Polymerase II Transcription Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 9 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cell division protein kinase 9
Gene namesi
Name:CDK9
ORF Names:RCJMB04_9p8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 17

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858031 – 372Cyclin-dependent kinase 9Add BLAST372

Proteomic databases

PaxDbiQ5ZKN1.

Interactioni

Subunit structurei

Associates with cyclin-T to form P-TEFb. Also associates with cyclin-K (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008078.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKN1.
SMRiQ5ZKN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 315Protein kinasePROSITE-ProRule annotationAdd BLAST297

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
GeneTreeiENSGT00890000139396.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ5ZKN1.
KOiK02211.
PhylomeDBiQ5ZKN1.
TreeFamiTF101039.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZKN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKQYDMVEC PFCDEVSKYE KLAKIGQGTF GEVFKAKHRQ TGKKVALKKV
60 70 80 90 100
LMENEKEGFP ITALREIKIL QLLKHENVVN LIEICRTKAS PYNRCKGSIY
110 120 130 140 150
LVFDFCEHDL AGLLSNTHVK FTLSEIKKVM QMLLNGLYYI HRNKILHRDM
160 170 180 190 200
KAANVLITRD GVLKLADFGL ARAFSLAKNS QPNRYTNRVV TLWYRPPELL
210 220 230 240 250
LGERDYGPPI DLWGGGCIMA EMWTRSPIMQ GNTEQHQLTL ISQLCGSITP
260 270 280 290 300
EVWPNVDKYE LYQKLELPKG QKRKVKDRLK AYVKDPYALD LIDKLLVLDP
310 320 330 340 350
AQRIDSDDAL NHDFFWSDPM PSDLKNMLST HNQSMFEYLA PPRRRGGHMP
360 370
QQPANQGRNP AATNQTEFDR VF
Length:372
Mass (Da):42,803
Last modified:November 23, 2004 - v1
Checksum:iC16F2AADEB04C4CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720053 mRNA. Translation: CAG31712.1.
RefSeqiNP_001006201.1. NM_001006201.2.
UniGeneiGga.2483.
Gga.51307.

Genome annotation databases

EnsembliENSGALT00000082010; ENSGALP00000047028; ENSGALG00000035576.
GeneIDi417226.
KEGGigga:417226.

Similar proteinsi

Entry informationi

Entry nameiCDK9_CHICK
AccessioniPrimary (citable) accession number: Q5ZKN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 23, 2004
Last modified: August 30, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families