Reviewed,
UniProtKB/Swiss-Prot Q5ZKN1 (CDK9_CHICK)
Last modified
January 19, 2010.
Version 47.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cell division protein kinase 9 EC=2.7.11.22 EC=2.7.11.23 Alternative name(s): Cyclin-dependent kinase 9 | ||||
| Gene names |
| ||||
| Organism | Gallus gallus (Chicken) | ||||
| Taxonomic identifier | 9031 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 372 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro By similarity. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. |
| Subunit structure | Associates with cyclin-T to form P-TEFb. Also associates with cyclin-K By similarity. |
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II carboxy-terminal domain kinase activityInferred from electronic annotation. Source: EC cyclin-dependent protein kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 372 | 372 | Cell division protein kinase 9 | PRO_0000085803 | |||||
Regions | |||||||||
| Domain | 19 – 315 | 297 | Protein kinase | ||||||
| Nucleotide binding | 25 – 33 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 149 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 48 | 1 | ATP By similarity | ||||||
Sequences
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References
| [1] | "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ720053 mRNA. Translation: CAG31712.1. |
| IPI | IPI00593778. |
| RefSeq | NP_001006201.1. |
| UniGene | Gga.2483 |
3D structure databases | |
| SMR | Q5ZKN1. Positions 8-325. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5ZKN1. |
Genome annotation databases | |
| Ensembl | ENSGALT00000008092; ENSGALP00000008078; ENSGALG00000005045; Gallus gallus. [Genome view] |
| GeneID | 417226. |
| KEGG | gga:417226. |
Organism-specific databases | |
| CTD | 417226. |
Phylogenomic databases | |
| eggNOG | veNOG08558. |
| HOGENOM | HBG755340. |
| HOVERGEN | Q5ZKN1. |
| InParanoid | Q5ZKN1. |
| OMA | FKARHRK. |
| OrthoDB | EOG9MGVSS. |
| PhylomeDB | Q5ZKN1. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.22. 4. 2.7.11.23. 4. |
Family and domain databases | |
| InterPro | IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CDK9_CHICK | ||||||||
| Accession | Primary (citable) accession number: Q5ZKN1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

Clusters with


