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Protein

pre-rRNA processing protein FTSJ3

Gene

FTSJ3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylnucleoside.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
Binding sitei58 – 581S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
Binding sitei76 – 761S-adenosyl-L-methionineUniRule annotation
Binding sitei92 – 921S-adenosyl-L-methionineUniRule annotation
Binding sitei117 – 1171S-adenosyl-L-methionineUniRule annotation
Active sitei157 – 1571Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
pre-rRNA processing protein FTSJ3UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
2'-O-ribose RNA methyltransferase SPB1 homologUniRule annotation
Protein ftsJ homolog 3UniRule annotation
Putative rRNA methyltransferase 3UniRule annotation
Gene namesi
Name:FTSJ3UniRule annotation
ORF Names:RCJMB04_10b6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleusnucleolus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 832832pre-rRNA processing protein FTSJ3PRO_0000155581Add
BLAST

Proteomic databases

PaxDbiQ5ZKM1.

Interactioni

Subunit structurei

Interacts with NIP7.UniRule annotation

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039839.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili726 – 75833UniRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi338 – 522185Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1098. Eukaryota.
COG0293. LUCA.
HOGENOMiHOG000162368.
HOVERGENiHBG075246.
InParanoidiQ5ZKM1.
KOiK14857.
PhylomeDBiQ5ZKM1.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01547. RNA_methyltr_E.
MF_03163. RNA_methyltr_E_SPB1.
InterProiIPR015507. rRNA-MeTfrase_E.
IPR012920. rRNA_MeTfrase_Spb1_C.
IPR024576. rRNA_MeTfrase_Spb1_DUF3381.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases.
IPR028589. Spb1.
[Graphical view]
PANTHERiPTHR10920. PTHR10920. 2 hits.
PTHR10920:SF13. PTHR10920:SF13. 2 hits.
PfamiPF11861. DUF3381. 1 hit.
PF01728. FtsJ. 1 hit.
PF07780. Spb1_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZKM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKSKVGKS RRDKFYHLAK ETGFRSRSAF KLLQLNRKFQ FLQKARALLD
60 70 80 90 100
LCAAPGGWLQ VASKFMPVSS LVIGVDLVPI KPIPNVVTLQ EDITTEKCRQ
110 120 130 140 150
ALRKELQTWK VDVVLNDGAP NVGASWVHDA YSQANLTLMA LKLACEFLCK
160 170 180 190 200
GGWFITKVFR SRDYQPLLWI FQQFFHKVQA TKPQASRNES AEIFVVCQGY
210 220 230 240 250
QAPDKIDSKF FDPKYAFKEV EVHAKSVSEL VSKKKPKAEG YADGDTTLYH
260 270 280 290 300
RFTLMDFLKA PNPVDFLSKA NEITLGDGEL ENHSSTTEEL RQCCKDIRVL
310 320 330 340 350
GRKELRALLN WRTKLRRFLT KKLKEQAKEL DINLSSGEEE EGREEEEKTS
360 370 380 390 400
PKAAADEMVK EEEEEVELAL AEMKAKELAE LKRKKKKILK EQRKQRERVE
410 420 430 440 450
LKMDLPGVSI ADDGDTSMFS LQTIQRTQLL NEVARGDMAS ADALLEMRPG
460 470 480 490 500
DDDICVSDAD DEDDVSLASD LDPEELVEIE ARQRRLERER REQGVKRVKP
510 520 530 540 550
KVEEEEEEEE EEENPLLVPL EEKSVLQERQ TSLWFGKDAF AGIEDDADED
560 570 580 590 600
LELGQSQMLA ERQRESQTGK TKKKGQKKKV PQESTAAEPQ DAADTGADTA
610 620 630 640 650
EAEAEQSSDD DSSSDEEGPP TPVGRKRGLV EPCGFEVVPI EDPVKKARVL
660 670 680 690 700
DAEGLALGSV IATSKKAKRD LIDDSFNRYS FNEEEGELPE WFTEEEKQHR
710 720 730 740 750
RKQIPLDKQT VEEYRQRWRQ INARPIKKVA EAKARKKRRM LKKMEQMKKK
760 770 780 790 800
AEAVVSTVDI SEREKVAQLR RIYKKAGLGK EKRQVTYLVA KKGVGPRVRR
810 820 830
PPGVKGQFKV VDSRLKKDVR AQKRKEQKKR RK
Length:832
Mass (Da):95,006
Last modified:August 16, 2005 - v2
Checksum:iB03A332C19730EA9
GO

Sequence cautioni

The sequence CAG31722.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → V (PubMed:15642098).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720063 mRNA. Translation: CAG31722.1. Different initiation.
AADN02056696 Genomic DNA. No translation available.
AADN02061717 Genomic DNA. No translation available.
AADN02056695 Genomic DNA. No translation available.
RefSeqiNP_001026096.2. NM_001030925.2.
UniGeneiGga.22345.

Genome annotation databases

GeneIDi419943.
KEGGigga:419943.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720063 mRNA. Translation: CAG31722.1. Different initiation.
AADN02056696 Genomic DNA. No translation available.
AADN02061717 Genomic DNA. No translation available.
AADN02056695 Genomic DNA. No translation available.
RefSeqiNP_001026096.2. NM_001030925.2.
UniGeneiGga.22345.

3D structure databases

ProteinModelPortaliQ5ZKM1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039839.

Proteomic databases

PaxDbiQ5ZKM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi419943.
KEGGigga:419943.

Organism-specific databases

CTDi117246.

Phylogenomic databases

eggNOGiKOG1098. Eukaryota.
COG0293. LUCA.
HOGENOMiHOG000162368.
HOVERGENiHBG075246.
InParanoidiQ5ZKM1.
KOiK14857.
PhylomeDBiQ5ZKM1.

Miscellaneous databases

NextBioi20822928.
PROiQ5ZKM1.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01547. RNA_methyltr_E.
MF_03163. RNA_methyltr_E_SPB1.
InterProiIPR015507. rRNA-MeTfrase_E.
IPR012920. rRNA_MeTfrase_Spb1_C.
IPR024576. rRNA_MeTfrase_Spb1_DUF3381.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases.
IPR028589. Spb1.
[Graphical view]
PANTHERiPTHR10920. PTHR10920. 2 hits.
PTHR10920:SF13. PTHR10920:SF13. 2 hits.
PfamiPF11861. DUF3381. 1 hit.
PF01728. FtsJ. 1 hit.
PF07780. Spb1_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.
  2. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowl.

Entry informationi

Entry nameiSPB1_CHICK
AccessioniPrimary (citable) accession number: Q5ZKM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: November 11, 2015
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.