SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5ZKK4

- MESD_CHICK

UniProt

Q5ZKK4 - MESD_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

LDLR chaperone MESD

Gene
MESDC2, mesd, RCJMB04_10e14
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway By similarity.

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
LDLR chaperone MESD
Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Gene namesi
Name:MESDC2
Synonyms:mesd
ORF Names:RCJMB04_10e14
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 220198LDLR chaperone MESDPRO_0000385019Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi187 – 1871N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5ZKK4.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

BioGridi677117. 1 interaction.
IntActiQ5ZKK4. 1 interaction.
STRINGi9031.ENSGALP00000010323.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 17074Structured core By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi217 – 2204Prevents secretion from ER

Sequence similaritiesi

Belongs to the MESD family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG286690.
HOGENOMiHOG000230558.
InParanoidiQ5ZKK4.
PhylomeDBiQ5ZKK4.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZKK4-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAARWAAL GLALWLCAAA HAEEPEGKRR AGPAKKKDIR DYNDADMARL    50
LEQWEKDDDI EEGDLPEHKR PPAPIDFSKI DPGKPESILK LTKKGKTLMM 100
FVTVSGNPTE KETEEITSLW QGSLFNANYD VQRFIVGSNR AIFMLRDGGY 150
AWEIKDFLIS QERCADVTLE GQVYPGKGAD GSEKGRNKTK PEKAKKKKDA 200
EKSKSSHEDN RAQTKQREDL 220
Length:220
Mass (Da):24,692
Last modified:September 22, 2009 - v2
Checksum:i663982BAED40D934
GO

Sequence cautioni

The sequence CAG31739.1 differs from that shown. Reason: Frameshift at position 213.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720080 mRNA. Translation: CAG31739.1. Frameshift.
DR420681 mRNA. No translation available.
RefSeqiNP_001025722.1. NM_001030551.1.
UniGeneiGga.17143.

Genome annotation databases

GeneIDi415475.
KEGGigga:415475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720080 mRNA. Translation: CAG31739.1 . Frameshift.
DR420681 mRNA. No translation available.
RefSeqi NP_001025722.1. NM_001030551.1.
UniGenei Gga.17143.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 677117. 1 interaction.
IntActi Q5ZKK4. 1 interaction.
STRINGi 9031.ENSGALP00000010323.

Proteomic databases

PaxDbi Q5ZKK4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 415475.
KEGGi gga:415475.

Organism-specific databases

CTDi 23184.

Phylogenomic databases

eggNOGi NOG286690.
HOGENOMi HOG000230558.
InParanoidi Q5ZKK4.
PhylomeDBi Q5ZKK4.

Miscellaneous databases

NextBioi 20819072.
PROi Q5ZKK4.

Family and domain databases

InterProi IPR019330. Mesoderm_development_cand-2.
[Graphical view ]
Pfami PF10185. Mesd. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.
  2. "Gene expression profiling of chicken primordial germ cell ESTs."
    Han J.Y., Park T.S., Kim J.N., Kim M.A., Lim D., Lim J.M., Kim H.
    BMC Genomics 7:220-220(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: White leghorn.
    Tissue: Embryo.

Entry informationi

Entry nameiMESD_CHICK
AccessioniPrimary (citable) accession number: Q5ZKK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: April 16, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi