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Q5ZKK4

- MESD_CHICK

UniProt

Q5ZKK4 - MESD_CHICK

Protein

LDLR chaperone MESD

Gene

MESDC2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 2 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway By similarity.By similarity

    GO - Biological processi

    1. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LDLR chaperone MESD
    Alternative name(s):
    Mesoderm development candidate 2
    Mesoderm development protein
    Gene namesi
    Name:MESDC2
    Synonyms:mesd
    ORF Names:RCJMB04_10e14
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 220198LDLR chaperone MESDPRO_0000385019Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ5ZKK4.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi677117. 1 interaction.
    IntActiQ5ZKK4. 1 interaction.
    STRINGi9031.ENSGALP00000010323.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni97 – 17074Structured coreBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi217 – 2204Prevents secretion from ER

    Sequence similaritiesi

    Belongs to the MESD family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG286690.
    HOGENOMiHOG000230558.
    InParanoidiQ5ZKK4.
    PhylomeDBiQ5ZKK4.

    Family and domain databases

    InterProiIPR019330. Mesoderm_development_cand-2.
    [Graphical view]
    PfamiPF10185. Mesd. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5ZKK4-1 [UniParc]FASTAAdd to Basket

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    MAAAARWAAL GLALWLCAAA HAEEPEGKRR AGPAKKKDIR DYNDADMARL    50
    LEQWEKDDDI EEGDLPEHKR PPAPIDFSKI DPGKPESILK LTKKGKTLMM 100
    FVTVSGNPTE KETEEITSLW QGSLFNANYD VQRFIVGSNR AIFMLRDGGY 150
    AWEIKDFLIS QERCADVTLE GQVYPGKGAD GSEKGRNKTK PEKAKKKKDA 200
    EKSKSSHEDN RAQTKQREDL 220
    Length:220
    Mass (Da):24,692
    Last modified:September 22, 2009 - v2
    Checksum:i663982BAED40D934
    GO

    Sequence cautioni

    The sequence CAG31739.1 differs from that shown. Reason: Frameshift at position 213.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720080 mRNA. Translation: CAG31739.1. Frameshift.
    DR420681 mRNA. No translation available.
    RefSeqiNP_001025722.1. NM_001030551.1.
    UniGeneiGga.17143.

    Genome annotation databases

    GeneIDi415475.
    KEGGigga:415475.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720080 mRNA. Translation: CAG31739.1 . Frameshift.
    DR420681 mRNA. No translation available.
    RefSeqi NP_001025722.1. NM_001030551.1.
    UniGenei Gga.17143.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 677117. 1 interaction.
    IntActi Q5ZKK4. 1 interaction.
    STRINGi 9031.ENSGALP00000010323.

    Proteomic databases

    PaxDbi Q5ZKK4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 415475.
    KEGGi gga:415475.

    Organism-specific databases

    CTDi 23184.

    Phylogenomic databases

    eggNOGi NOG286690.
    HOGENOMi HOG000230558.
    InParanoidi Q5ZKK4.
    PhylomeDBi Q5ZKK4.

    Miscellaneous databases

    NextBioi 20819072.
    PROi Q5ZKK4.

    Family and domain databases

    InterProi IPR019330. Mesoderm_development_cand-2.
    [Graphical view ]
    Pfami PF10185. Mesd. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.
    2. "Gene expression profiling of chicken primordial germ cell ESTs."
      Han J.Y., Park T.S., Kim J.N., Kim M.A., Lim D., Lim J.M., Kim H.
      BMC Genomics 7:220-220(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: White leghorn.
      Tissue: Embryo.

    Entry informationi

    Entry nameiMESD_CHICK
    AccessioniPrimary (citable) accession number: Q5ZKK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 47 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3