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Protein

LDLR chaperone MESD

Gene

MESDC2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
LDLR chaperone MESD
Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Gene namesi
Name:MESDC2
Synonyms:mesd
ORF Names:RCJMB04_10e14
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000038501923 – 220LDLR chaperone MESDAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5ZKK4.

Expressioni

Gene expression databases

BgeeiENSGALG00000006403.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi677117. 1 interactor.
IntActiQ5ZKK4. 1 interactor.
STRINGi9031.ENSGALP00000010323.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 170Structured coreBy similarityAdd BLAST74

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi217 – 220Prevents secretion from ER4

Sequence similaritiesi

Belongs to the MESD family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4357. Eukaryota.
ENOG4111SG4. LUCA.
HOGENOMiHOG000230558.
InParanoidiQ5ZKK4.
PhylomeDBiQ5ZKK4.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZKK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAARWAAL GLALWLCAAA HAEEPEGKRR AGPAKKKDIR DYNDADMARL
60 70 80 90 100
LEQWEKDDDI EEGDLPEHKR PPAPIDFSKI DPGKPESILK LTKKGKTLMM
110 120 130 140 150
FVTVSGNPTE KETEEITSLW QGSLFNANYD VQRFIVGSNR AIFMLRDGGY
160 170 180 190 200
AWEIKDFLIS QERCADVTLE GQVYPGKGAD GSEKGRNKTK PEKAKKKKDA
210 220
EKSKSSHEDN RAQTKQREDL
Length:220
Mass (Da):24,692
Last modified:September 22, 2009 - v2
Checksum:i663982BAED40D934
GO

Sequence cautioni

The sequence CAG31739 differs from that shown. Reason: Frameshift at position 213.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720080 mRNA. Translation: CAG31739.1. Frameshift.
DR420681 mRNA. No translation available.
UniGeneiGga.17143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720080 mRNA. Translation: CAG31739.1. Frameshift.
DR420681 mRNA. No translation available.
UniGeneiGga.17143.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi677117. 1 interactor.
IntActiQ5ZKK4. 1 interactor.
STRINGi9031.ENSGALP00000010323.

Proteomic databases

PaxDbiQ5ZKK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4357. Eukaryota.
ENOG4111SG4. LUCA.
HOGENOMiHOG000230558.
InParanoidiQ5ZKK4.
PhylomeDBiQ5ZKK4.

Gene expression databases

BgeeiENSGALG00000006403.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMESD_CHICK
AccessioniPrimary (citable) accession number: Q5ZKK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: November 30, 2016
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.