Q5ZKK4 (MESD_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
LDLR chaperone MESD

Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein

Gene names

Name:	MESDC2
Synonyms:	mesd
ORF Names:	RCJMB04_10e14

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	Endoplasmic reticulum By similarity.
Sequence similarities	Belongs to the MESD family.
Sequence caution	The sequence CAG31739.1 differs from that shown. Reason: Frameshift at position 213.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Endoplasmic reticulum
Domain	Signal
Molecular function	Chaperone
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 220	198	LDLR chaperone MESD		PRO_0000385019
Regions
	Region	97 – 170	74	Structured core By similarity
	Motif	217 – 220	4	Prevents secretion from ER
Amino acid modifications
	Glycosylation	187	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5ZKK4 [UniParc]. Last modified September 22, 2009. Version 2. Checksum: 663982BAED40D934	FASTA	220	24,692
	10 20 30 40 50 60 MAAAARWAAL GLALWLCAAA HAEEPEGKRR AGPAKKKDIR DYNDADMARL LEQWEKDDDI 70 80 90 100 110 120 EEGDLPEHKR PPAPIDFSKI DPGKPESILK LTKKGKTLMM FVTVSGNPTE KETEEITSLW 130 140 150 160 170 180 QGSLFNANYD VQRFIVGSNR AIFMLRDGGY AWEIKDFLIS QERCADVTLE GQVYPGKGAD 190 200 210 220 GSEKGRNKTK PEKAKKKKDA EKSKSSHEDN RAQTKQREDL

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

[2]

"Gene expression profiling of chicken primordial germ cell ESTs." Han J.Y., Park T.S., Kim J.N., Kim M.A., Lim D., Lim J.M., Kim H. BMC Genomics 7:220-220(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: White leghorn. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ720080 mRNA. Translation: CAG31739.1. Frameshift. DR420681 mRNA. No translation available.
IPI	IPI00574701.
RefSeq	NP_001025722.1. NM_001030551.1.
UniGene	Gga.17143.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5ZKK4. 1 interaction.
STRING	9031.ENSGALP00000010323.
Proteomic databases
PaxDb	Q5ZKK4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	415475.
KEGG	gga:415475.
Organism-specific databases
CTD	23184.
Phylogenomic databases
eggNOG	NOG286690.
HOGENOM	HOG000230558.
InParanoid	Q5ZKK4.
OrthoDB	EOG4QRH59.
Family and domain databases
InterPro	IPR019330. Mesoderm_development_cand-2. [Graphical view]
Pfam	PF10185. Mesd. 1 hit. [Graphical view]
PROSITE	PS00014. ER_TARGET. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	20819072.

Entry information

Entry name

MESD_CHICK

Accession

Primary (citable) accession number: Q5ZKK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	April 3, 2013
This is version 39 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program