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Q5ZKK4 (MESD_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LDLR chaperone MESD
Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Gene names
Name:MESDC2
Synonyms:mesd
ORF Names:RCJMB04_10e14
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the MESD family.

Sequence caution

The sequence CAG31739.1 differs from that shown. Reason: Frameshift at position 213.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionChaperone
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 220198LDLR chaperone MESD
PRO_0000385019

Regions

Region97 – 17074Structured core By similarity
Motif217 – 2204Prevents secretion from ER

Amino acid modifications

Glycosylation1871N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5ZKK4 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: 663982BAED40D934

FASTA22024,692
        10         20         30         40         50         60 
MAAAARWAAL GLALWLCAAA HAEEPEGKRR AGPAKKKDIR DYNDADMARL LEQWEKDDDI 

        70         80         90        100        110        120 
EEGDLPEHKR PPAPIDFSKI DPGKPESILK LTKKGKTLMM FVTVSGNPTE KETEEITSLW 

       130        140        150        160        170        180 
QGSLFNANYD VQRFIVGSNR AIFMLRDGGY AWEIKDFLIS QERCADVTLE GQVYPGKGAD 

       190        200        210        220 
GSEKGRNKTK PEKAKKKKDA EKSKSSHEDN RAQTKQREDL 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.
[2]"Gene expression profiling of chicken primordial germ cell ESTs."
Han J.Y., Park T.S., Kim J.N., Kim M.A., Lim D., Lim J.M., Kim H.
BMC Genomics 7:220-220(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: White leghorn.
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ720080 mRNA. Translation: CAG31739.1. Frameshift.
DR420681 mRNA. No translation available.
RefSeqNP_001025722.1. NM_001030551.1.
UniGeneGga.17143.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid677117. 1 interaction.
IntActQ5ZKK4. 1 interaction.
STRING9031.ENSGALP00000010323.

Proteomic databases

PaxDbQ5ZKK4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID415475.
KEGGgga:415475.

Organism-specific databases

CTD23184.

Phylogenomic databases

eggNOGNOG286690.
HOGENOMHOG000230558.
InParanoidQ5ZKK4.
PhylomeDBQ5ZKK4.

Family and domain databases

InterProIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamPF10185. Mesd. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20819072.
PROQ5ZKK4.

Entry information

Entry nameMESD_CHICK
AccessionPrimary (citable) accession number: Q5ZKK4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: April 16, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families