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Protein

Anaphase-promoting complex subunit 5

Gene

ANAPC5

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 5
Short name:
APC5
Alternative name(s):
Cyclosome subunit 5
Gene namesi
Name:ANAPC5
ORF Names:RCJMB04_10e17
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 756756Anaphase-promoting complex subunit 5PRO_0000307378Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5ZKK3.

Interactioni

Subunit structurei

The APC/C is composed of at least 12 subunits.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006629.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati301 – 33434TPR 1Add
BLAST
Repeati522 – 55534TPR 2Add
BLAST
Repeati581 – 61434TPR 3Add
BLAST
Repeati678 – 71134TPR 4Add
BLAST

Sequence similaritiesi

Belongs to the APC5 family.Curated
Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4322. Eukaryota.
ENOG410YVZN. LUCA.
HOGENOMiHOG000033988.
HOVERGENiHBG001285.
InParanoidiQ5ZKK3.
KOiK03352.
PhylomeDBiQ5ZKK3.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR026000. Apc5_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF12862. ANAPC5. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.

Sequencei

Sequence statusi: Complete.

Q5ZKK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVHESLYF NPMMTNGVVH ANVFGIKDWV TPYKMALLVL LSELGRAGSQ
60 70 80 90 100
LDQLERRRLN RLLLPLLQGP DMPLSRLRKA IEECCPNLAG SVHIRLKLIA
110 120 130 140 150
EGELKDMEQF FDDLSDSFSG TEPEVHKTSV IGLFLRHMIL AYNKLSFSQV
160 170 180 190 200
YKLYTALQQY FLNDEKKCGI DENDMELTNT EELDGKMEKE ELDVPLREEE
210 220 230 240 250
ISCSGPLSQK QAEYFLSQQA SLLKNDETKA LSPVSLQKEL NNLLKFNPDF
260 270 280 290 300
AEAHYLSYLN SLRVHDVFSS THSLLHYFDR LILTGAESKS NGDEGYGRSL
310 320 330 340 350
RYAALNLAAL HCRFGHYQQA ELALQEAIRI AQESNDHVCL QHCLSWLHIS
360 370 380 390 400
EQKIFDSCVL LEHSVNKSLH FGLPYLASLG IQSLVQQRAF AGKAANKLMD
410 420 430 440 450
ALKDSDLLHW KHSLSELIDI SIAQKTAIWR LYGRSTMALQ QAQTLLSMNS
460 470 480 490 500
LEAVNVGVQQ NNTEAFAVVL CHLAELHAEQ GYFAAASEIL KHLKERFPPN
510 520 530 540 550
SQHAQLWMLF DQKIQFERAM NDGRYHIADS LVAGITALNS IEGMYRKAIV
560 570 580 590 600
LKAQNQMLEA HKLLQKLLIH CQEIKNTEIV ISVLLSVAEL YWRSSCHTIA
610 620 630 640 650
LPVLLQALAF SREYSLQYLA SETVLNLAFS QLILGVPEQV LNILHMAIEP
660 670 680 690 700
GLAHGAVLDK GCAMFLVAKC QVASTASYSQ QKKAEALESA ILNLNEAKTY
710 720 730 740 750
LAKVDCKEQL RDVLYFQARL FHTLGKTQER NKCAMLFRQL HQELPAHGVP

LINAFK
Length:756
Mass (Da):85,306
Last modified:November 23, 2004 - v1
Checksum:i72F4A46EE8486ADE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720081 mRNA. Translation: CAG31740.1.
RefSeqiNP_001006187.1. NM_001006187.1.
UniGeneiGga.22370.

Genome annotation databases

GeneIDi416842.
KEGGigga:416842.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720081 mRNA. Translation: CAG31740.1.
RefSeqiNP_001006187.1. NM_001006187.1.
UniGeneiGga.22370.

3D structure databases

ProteinModelPortaliQ5ZKK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006629.

Proteomic databases

PaxDbiQ5ZKK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi416842.
KEGGigga:416842.

Organism-specific databases

CTDi51433.

Phylogenomic databases

eggNOGiKOG4322. Eukaryota.
ENOG410YVZN. LUCA.
HOGENOMiHOG000033988.
HOVERGENiHBG001285.
InParanoidiQ5ZKK3.
KOiK03352.
PhylomeDBiQ5ZKK3.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ5ZKK3.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR026000. Apc5_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF12862. ANAPC5. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiAPC5_CHICK
AccessioniPrimary (citable) accession number: Q5ZKK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.