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Protein

Integrator complex subunit 9

Gene

INTS9

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.By similarity

Miscellaneous

Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-GGA-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 9
Short name:
Int9
Gene namesi
Name:INTS9
ORF Names:RCJMB04_10e20
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595601 – 658Integrator complex subunit 9Add BLAST658

Proteomic databases

PaxDbiQ5ZKK2.

Expressioni

Gene expression databases

BgeeiENSGALG00000016631.
ExpressionAtlasiQ5ZKK2. baseline and differential.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026797.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1138. Eukaryota.
COG1236. LUCA.
GeneTreeiENSGT00390000001445.
HOGENOMiHOG000045359.
HOVERGENiHBG081802.
InParanoidiQ5ZKK2.
KOiK13146.
PhylomeDBiQ5ZKK2.
TreeFamiTF314100.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiView protein in InterPro
IPR022712. Beta_Casp.
IPR027074. Integrator_9su.
IPR001279. Metallo-B-lactamas.
PANTHERiPTHR11203:SF44. PTHR11203:SF44. 1 hit.
PfamiView protein in Pfam
PF10996. Beta-Casp. 1 hit.
PF16661. Lactamase_B_6. 1 hit.
SMARTiView protein in SMART
SM01027. Beta-Casp. 1 hit.
SUPFAMiSSF56281. SSF56281. 3 hits.

Sequencei

Sequence statusi: Complete.

Q5ZKK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLYCLSGHP TLPCNVLKFK STTIMLDCGL DMTSTLNFLP LPLVQSPRLS
60 70 80 90 100
KLPGLVLKDG STFLDKELKE CSGHVFVDSV PEFCLPETEL LDLSTVDVIL
110 120 130 140 150
ISNYHCMMAL PYITEYTGFT GTVYATEPTV QIGRLLMEEL VNSIERVPKA
160 170 180 190 200
QSASTWKNKE VQRLLPAPLK DAVEVSMWRK CYTMPEVNAA LSKIQLVGYS
210 220 230 240 250
QKIELFGAVQ VTPLSSGYAL GSSNWIIQSH YEKVSYVSGS SLLTTHPQPM
260 270 280 290 300
DQASLKNSDV LILTGLTQIP TANPDGMVGE FCSNLAMTVR NGGNVLVPCY
310 320 330 340 350
PSGVIYDLLE CLYQYIDSAG LSNVPFYFIS PVANSSLEFS QIFAEWLCHN
360 370 380 390 400
KQTKVYLPEP PFPHAELIQT NKLKHYPSIH GDFSNDFKQP CVIFTGHPSL
410 420 430 440 450
RFGDVVHFME LWGKSSLNTV IFTEPDFSYL DALAPYQPLA MKCVYCPIDT
460 470 480 490 500
RLNFIQVSKL LKEVQPLHVV CPEQYTQPPP SQSHRTDLMI DCQPPPMSYR
510 520 530 540 550
RAEVLTLPYK RRYEKIEIMP ELADSLVPLE IKPGISLATV SAMLHTKDNK
560 570 580 590 600
HVLQLPPKPP QPPTSKKRKR VSDDVPECKP LKPLLSGSIP VDQFVQTLEK
610 620 630 640 650
HGFSDVKVED TAKGHIVLLQ EAETLIQIEE DSTHIICDND EPLRVKLRDL

VLKFLQKF
Length:658
Mass (Da):73,763
Last modified:November 23, 2004 - v1
Checksum:iA6B83632B1B3704D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720082 mRNA. Translation: CAG31741.1.
RefSeqiNP_001026271.1. NM_001031100.1.
UniGeneiGga.21113.

Genome annotation databases

EnsembliENSGALT00000026848; ENSGALP00000026797; ENSGALG00000016631.
GeneIDi422023.
KEGGigga:422023.

Similar proteinsi

Entry informationi

Entry nameiINT9_CHICK
AccessioniPrimary (citable) accession number: Q5ZKK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: July 5, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families