Reviewed,
UniProtKB/Swiss-Prot Q5ZKI0 (KCC2D_CHICK)
Last modified
September 1, 2009.
Version 46.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Calcium/calmodulin-dependent protein kinase type II delta chain Short name=CaM-kinase II delta chain Short name=CaM kinase II subunit delta Short name=CaMK-II subunit delta EC=2.7.11.17 | ||||
| Gene names |
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| Organism | Gallus gallus (Chicken) | ||||
| Taxonomic identifier | 9031 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 479 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system By similarity. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Enzyme regulation | Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity By similarity. |
| Subunit structure | CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits By similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding Calmodulin-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin bindingInferred from electronic annotation. Source: UniProtKB-KW calmodulin-dependent protein kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 479 | 479 | Calcium/calmodulin-dependent protein kinase type II delta chain | PRO_0000277820 | |||||
Regions | |||||||||
| Domain | 14 – 272 | 259 | Protein kinase | ||||||
| Nucleotide binding | 20 – 28 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 136 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 43 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 287 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 315 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 319 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 337 | 1 | Phosphothreonine By similarity | ||||||
Sequences
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References
| [1] | "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:RESEARCH006.1-RESEARCH006.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius. |
Cross-references
Sequence databases | |
|---|---|
| AJ720104 mRNA. Translation: CAG31763.1. | |
| IPI | IPI00582730. |
| RefSeq | NP_001034389.1. |
| UniGene | Gga.17348 |
3D structure databases | |
| SMR | Q5ZKI0. Positions 8-315, 339-472. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5ZKI0. |
Genome annotation databases | |
| Ensembl | ENSGALT00000019642; ENSGALP00000019616; ENSGALG00000012036; Gallus gallus. [Genome view] ENSGALT00000037701; ENSGALP00000036906; ENSGALG00000012036; Gallus gallus. [Genome view] |
| GeneID | 422688. |
| KEGG | gga:422688. |
Organism-specific databases | |
| CTD | 422688. |
Phylogenomic databases | |
| HOVERGEN | Q5ZKI0. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.17. 4. |
Family and domain databases | |
| InterPro | IPR015742. Ca/calmodulin-dep_kinase. IPR013543. Ca/calmodulin-dep_kinase-assoc. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view] |
| PANTHER | PTHR22982:SF64. CaMKII. 1 hit. |
| Pfam | PF08332. CaMKII_AD. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KCC2D_CHICK | ||||||||
| Accession | Primary (citable) accession number: Q5ZKI0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

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