Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone deacetylase 9

Gene

hdac9

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  5. transcription corepressor activity Source: AgBase

GO - Biological processi

  1. heart development Source: AgBase
  2. negative regulation of transcription, DNA-templated Source: AgBase
  3. negative regulation of transcription from RNA polymerase II promoter Source: AgBase
  4. regulation of skeletal muscle fiber development Source: UniProtKB
  5. regulation of striated muscle cell differentiation Source: UniProtKB
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 9 (EC:3.5.1.98)
Gene namesi
Name:hdac9
ORF Names:RCJMB04_10m2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. histone methyltransferase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Histone deacetylase 9PRO_0000280536Add
BLAST

Proteomic databases

PaxDbiQ5ZKH6.

Interactioni

Subunit structurei

Homodimer. Interacts with mef2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017619.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKH6.
SMRiQ5ZKH6. Positions 37-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni143 – 19351Interaction with mef2By similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000232065.
HOVERGENiHBG057100.
InParanoidiQ5ZKH6.
PhylomeDBiQ5ZKH6.

Family and domain databases

InterProiIPR000286. His_deacetylse.
IPR024643. Hist_deacetylase_Gln_rich_N.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZKH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSMISSVDV KSEVPVGLEP ISPLDLRTDL RMMVPMVDPI MREKQLQQEL
60 70 80 90 100
LLIQQQQQIQ KQLLIAEFQK QHENLTRQHQ AQLQEHIKLQ QELLAIKQQQ
110 120 130 140 150
ELLEKEQKLE QQRQEQELER HRREQQLPPL RGKERGRERA VASTEVKQKL
160 170 180 190 200
QEFLLSKSAT KDSPANGKNH SVSRHPKLWY TAAHHTSLDQ SSPPLSGASP
210 220 230 240 250
PYKYTLPGSQ DAKDDFPLRK TASEPNLKVR SRLKQKVTER RSSPLLRRKD
260 270 280 290 300
GNVVSSFKKR LFEVTESSVS SSSPGSGPSS PSNGPTSSIT ESETSVLPSS
310 320 330 340 350
IQAEHLVSQQ RLLIQDESVN LLSLYTSPSL PNITLGLPAV QSQISASSSF
360 370 380 390 400
KEKQKGETQT LRPGVALAGQ YGGNLPPSST HPHVALEGKP NSSHQALLQH
410 420 430 440 450
LLLKEQMRQQ KLLVTGAVPL HPQSPLAAKE RGSPGVRAAH KLPRHRPLNR
460 470 480 490 500
TQSAPLPQST LAQLVIQQQH QQFLEKQKQY QQQIHMNKML SKSIEQLKQP
510 520 530 540 550
GSHLEEAEEE LNGDHSMQEE RAPASSASIR AESSSAGEDD RIGQQVGAVK
560 570 580 590
VKEEPPDSDE DTQTQQMESG EQAAFVQQVI GKDLAPGFVI KVII
Length:594
Mass (Da):66,214
Last modified:November 23, 2004 - v1
Checksum:iC3BA308AA746BA5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720108 mRNA. Translation: CAG31767.1.
UniGeneiGga.1378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720108 mRNA. Translation: CAG31767.1.
UniGeneiGga.1378.

3D structure databases

ProteinModelPortaliQ5ZKH6.
SMRiQ5ZKH6. Positions 37-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017619.

Proteomic databases

PaxDbiQ5ZKH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000232065.
HOVERGENiHBG057100.
InParanoidiQ5ZKH6.
PhylomeDBiQ5ZKH6.

Family and domain databases

InterProiIPR000286. His_deacetylse.
IPR024643. Hist_deacetylase_Gln_rich_N.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiHDAC9_CHICK
AccessioniPrimary (citable) accession number: Q5ZKH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: November 23, 2004
Last modified: February 4, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.