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Q5ZKH6 (HDAC9_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase 9

EC=3.5.1.98
Gene names
Name:hdac9
ORF Names:RCJMB04_10m2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subunit structure

Homodimer. Interacts with mef2 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Molecular functionChromatin regulator
Hydrolase
Repressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processheart development

Inferred from sequence or structural similarity. Source: AgBase

negative regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: AgBase

negative regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: AgBase

regulation of skeletal muscle fiber development

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of striated muscle cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthistone methyltransferase complex

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionNAD-dependent histone deacetylase activity (H3-K14 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K18 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K9 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H4-K16 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

transcription corepressor activity

Inferred from sequence or structural similarity. Source: AgBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 594594Histone deacetylase 9
PRO_0000280536

Regions

Region143 – 19351Interaction with mef2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZKH6 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: C3BA308AA746BA5E

FASTA59466,214
        10         20         30         40         50         60 
MHSMISSVDV KSEVPVGLEP ISPLDLRTDL RMMVPMVDPI MREKQLQQEL LLIQQQQQIQ 

        70         80         90        100        110        120 
KQLLIAEFQK QHENLTRQHQ AQLQEHIKLQ QELLAIKQQQ ELLEKEQKLE QQRQEQELER 

       130        140        150        160        170        180 
HRREQQLPPL RGKERGRERA VASTEVKQKL QEFLLSKSAT KDSPANGKNH SVSRHPKLWY 

       190        200        210        220        230        240 
TAAHHTSLDQ SSPPLSGASP PYKYTLPGSQ DAKDDFPLRK TASEPNLKVR SRLKQKVTER 

       250        260        270        280        290        300 
RSSPLLRRKD GNVVSSFKKR LFEVTESSVS SSSPGSGPSS PSNGPTSSIT ESETSVLPSS 

       310        320        330        340        350        360 
IQAEHLVSQQ RLLIQDESVN LLSLYTSPSL PNITLGLPAV QSQISASSSF KEKQKGETQT 

       370        380        390        400        410        420 
LRPGVALAGQ YGGNLPPSST HPHVALEGKP NSSHQALLQH LLLKEQMRQQ KLLVTGAVPL 

       430        440        450        460        470        480 
HPQSPLAAKE RGSPGVRAAH KLPRHRPLNR TQSAPLPQST LAQLVIQQQH QQFLEKQKQY 

       490        500        510        520        530        540 
QQQIHMNKML SKSIEQLKQP GSHLEEAEEE LNGDHSMQEE RAPASSASIR AESSSAGEDD 

       550        560        570        580        590 
RIGQQVGAVK VKEEPPDSDE DTQTQQMESG EQAAFVQQVI GKDLAPGFVI KVII 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ720108 mRNA. Translation: CAG31767.1.
UniGeneGga.1378.

3D structure databases

ProteinModelPortalQ5ZKH6.
SMRQ5ZKH6. Positions 37-104.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000017619.

Proteomic databases

PaxDbQ5ZKH6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0123.
HOGENOMHOG000232065.
HOVERGENHBG057100.
PhylomeDBQ5ZKH6.

Family and domain databases

InterProIPR000286. His_deacetylse.
IPR024643. Hist_deacetylase_Gln_rich_N.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF12203. HDAC4_Gln. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHDAC9_CHICK
AccessionPrimary (citable) accession number: Q5ZKH6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families