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Q5ZKH6

- HDAC9_CHICK

UniProt

Q5ZKH6 - HDAC9_CHICK

Protein

Histone deacetylase 9

Gene

hdac9

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    5. transcription corepressor activity Source: AgBase

    GO - Biological processi

    1. heart development Source: AgBase
    2. negative regulation of transcription, DNA-templated Source: AgBase
    3. negative regulation of transcription from RNA polymerase II promoter Source: AgBase
    4. regulation of skeletal muscle fiber development Source: UniProtKB
    5. regulation of striated muscle cell differentiation Source: UniProtKB
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 9 (EC:3.5.1.98)
    Gene namesi
    Name:hdac9
    ORF Names:RCJMB04_10m2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. histone methyltransferase complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594Histone deacetylase 9PRO_0000280536Add
    BLAST

    Proteomic databases

    PaxDbiQ5ZKH6.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with mef2 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000017619.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZKH6.
    SMRiQ5ZKH6. Positions 37-104.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni143 – 19351Interaction with mef2By similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    HOGENOMiHOG000232065.
    HOVERGENiHBG057100.
    PhylomeDBiQ5ZKH6.

    Family and domain databases

    InterProiIPR000286. His_deacetylse.
    IPR024643. Hist_deacetylase_Gln_rich_N.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF12203. HDAC4_Gln. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5ZKH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHSMISSVDV KSEVPVGLEP ISPLDLRTDL RMMVPMVDPI MREKQLQQEL    50
    LLIQQQQQIQ KQLLIAEFQK QHENLTRQHQ AQLQEHIKLQ QELLAIKQQQ 100
    ELLEKEQKLE QQRQEQELER HRREQQLPPL RGKERGRERA VASTEVKQKL 150
    QEFLLSKSAT KDSPANGKNH SVSRHPKLWY TAAHHTSLDQ SSPPLSGASP 200
    PYKYTLPGSQ DAKDDFPLRK TASEPNLKVR SRLKQKVTER RSSPLLRRKD 250
    GNVVSSFKKR LFEVTESSVS SSSPGSGPSS PSNGPTSSIT ESETSVLPSS 300
    IQAEHLVSQQ RLLIQDESVN LLSLYTSPSL PNITLGLPAV QSQISASSSF 350
    KEKQKGETQT LRPGVALAGQ YGGNLPPSST HPHVALEGKP NSSHQALLQH 400
    LLLKEQMRQQ KLLVTGAVPL HPQSPLAAKE RGSPGVRAAH KLPRHRPLNR 450
    TQSAPLPQST LAQLVIQQQH QQFLEKQKQY QQQIHMNKML SKSIEQLKQP 500
    GSHLEEAEEE LNGDHSMQEE RAPASSASIR AESSSAGEDD RIGQQVGAVK 550
    VKEEPPDSDE DTQTQQMESG EQAAFVQQVI GKDLAPGFVI KVII 594
    Length:594
    Mass (Da):66,214
    Last modified:November 23, 2004 - v1
    Checksum:iC3BA308AA746BA5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720108 mRNA. Translation: CAG31767.1.
    UniGeneiGga.1378.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720108 mRNA. Translation: CAG31767.1 .
    UniGenei Gga.1378.

    3D structure databases

    ProteinModelPortali Q5ZKH6.
    SMRi Q5ZKH6. Positions 37-104.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000017619.

    Proteomic databases

    PaxDbi Q5ZKH6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0123.
    HOGENOMi HOG000232065.
    HOVERGENi HBG057100.
    PhylomeDBi Q5ZKH6.

    Family and domain databases

    InterProi IPR000286. His_deacetylse.
    IPR024643. Hist_deacetylase_Gln_rich_N.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF12203. HDAC4_Gln. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiHDAC9_CHICK
    AccessioniPrimary (citable) accession number: Q5ZKH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3