Q5ZKH6 (HDAC9_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone deacetylase 9
EC=3.5.1.98

Gene names

Name:	hdac9
ORF Names:	RCJMB04_10m2

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	594 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription By similarity.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subunit structure	Homodimer. Interacts with mef2 By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone deacetylase family. HD type 2 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	heart development Inferred from sequence or structural similarity. Source: AgBase histone H3 deacetylation Inferred from electronic annotation. Source: GOC histone H4 deacetylation Inferred from electronic annotation. Source: GOC negative regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: AgBase regulation of skeletal muscle fiber development Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	histone methyltransferase complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	NAD-dependent histone deacetylase activity (H3-K14 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K18 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K9 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H4-K16 specific) Inferred from electronic annotation. Source: EC transcription corepressor activity Inferred from sequence or structural similarity. Source: AgBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 594	594	Histone deacetylase 9		PRO_0000280536
Regions
	Region	143 – 193	51	Interaction with mef2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZKH6 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: C3BA308AA746BA5E	FASTA	594	66,214
	10 20 30 40 50 60 MHSMISSVDV KSEVPVGLEP ISPLDLRTDL RMMVPMVDPI MREKQLQQEL LLIQQQQQIQ 70 80 90 100 110 120 KQLLIAEFQK QHENLTRQHQ AQLQEHIKLQ QELLAIKQQQ ELLEKEQKLE QQRQEQELER 130 140 150 160 170 180 HRREQQLPPL RGKERGRERA VASTEVKQKL QEFLLSKSAT KDSPANGKNH SVSRHPKLWY 190 200 210 220 230 240 TAAHHTSLDQ SSPPLSGASP PYKYTLPGSQ DAKDDFPLRK TASEPNLKVR SRLKQKVTER 250 260 270 280 290 300 RSSPLLRRKD GNVVSSFKKR LFEVTESSVS SSSPGSGPSS PSNGPTSSIT ESETSVLPSS 310 320 330 340 350 360 IQAEHLVSQQ RLLIQDESVN LLSLYTSPSL PNITLGLPAV QSQISASSSF KEKQKGETQT 370 380 390 400 410 420 LRPGVALAGQ YGGNLPPSST HPHVALEGKP NSSHQALLQH LLLKEQMRQQ KLLVTGAVPL 430 440 450 460 470 480 HPQSPLAAKE RGSPGVRAAH KLPRHRPLNR TQSAPLPQST LAQLVIQQQH QQFLEKQKQY 490 500 510 520 530 540 QQQIHMNKML SKSIEQLKQP GSHLEEAEEE LNGDHSMQEE RAPASSASIR AESSSAGEDD 550 560 570 580 590 RIGQQVGAVK VKEEPPDSDE DTQTQQMESG EQAAFVQQVI GKDLAPGFVI KVII

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ720108 mRNA. Translation: CAG31767.1.
IPI	IPI00971425.
UniGene	Gga.1378.
3D structure databases
ProteinModelPortal	Q5ZKH6.
SMR	Q5ZKH6. Positions 37-104.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000017619.
Proteomic databases
PaxDb	Q5ZKH6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000037899; ENSGALP00000037106; ENSGALG00000010854.
Phylogenomic databases
eggNOG	COG0123.
GeneTree	ENSGT00530000062809.
HOGENOM	HOG000232065.
HOVERGEN	HBG057100.
OrthoDB	EOG4R7VB0.
Gene expression databases
ArrayExpress	Q5ZKH6.
Family and domain databases
InterPro	IPR000286. His_deacetylse. IPR024643. Hist_deacetylase_Gln_rich_N. [Graphical view]
PANTHER	PTHR10625. PTHR10625. 1 hit.
Pfam	PF12203. HDAC4_Gln. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HDAC9_CHICK

Accession

Primary (citable) accession number: Q5ZKH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	November 23, 2004
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program