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Q5ZKH6

- HDAC9_CHICK

UniProt

Q5ZKH6 - HDAC9_CHICK

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Protein
Histone deacetylase 9
Gene
hdac9, RCJMB04_10m2
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription By similarity.

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  5. transcription corepressor activity Source: AgBase

GO - Biological processi

  1. heart development Source: AgBase
  2. negative regulation of transcription from RNA polymerase II promoter Source: AgBase
  3. negative regulation of transcription, DNA-templated Source: AgBase
  4. regulation of skeletal muscle fiber development Source: UniProtKB
  5. regulation of striated muscle cell differentiation Source: UniProtKB
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 9 (EC:3.5.1.98)
Gene namesi
Name:hdac9
ORF Names:RCJMB04_10m2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. histone methyltransferase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Histone deacetylase 9
PRO_0000280536Add
BLAST

Proteomic databases

PaxDbiQ5ZKH6.

Interactioni

Subunit structurei

Homodimer. Interacts with mef2 By similarity.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017619.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKH6.
SMRiQ5ZKH6. Positions 37-104.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni143 – 19351Interaction with mef2 By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000232065.
HOVERGENiHBG057100.
PhylomeDBiQ5ZKH6.

Family and domain databases

InterProiIPR000286. His_deacetylse.
IPR024643. Hist_deacetylase_Gln_rich_N.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZKH6-1 [UniParc]FASTAAdd to Basket

« Hide

MHSMISSVDV KSEVPVGLEP ISPLDLRTDL RMMVPMVDPI MREKQLQQEL    50
LLIQQQQQIQ KQLLIAEFQK QHENLTRQHQ AQLQEHIKLQ QELLAIKQQQ 100
ELLEKEQKLE QQRQEQELER HRREQQLPPL RGKERGRERA VASTEVKQKL 150
QEFLLSKSAT KDSPANGKNH SVSRHPKLWY TAAHHTSLDQ SSPPLSGASP 200
PYKYTLPGSQ DAKDDFPLRK TASEPNLKVR SRLKQKVTER RSSPLLRRKD 250
GNVVSSFKKR LFEVTESSVS SSSPGSGPSS PSNGPTSSIT ESETSVLPSS 300
IQAEHLVSQQ RLLIQDESVN LLSLYTSPSL PNITLGLPAV QSQISASSSF 350
KEKQKGETQT LRPGVALAGQ YGGNLPPSST HPHVALEGKP NSSHQALLQH 400
LLLKEQMRQQ KLLVTGAVPL HPQSPLAAKE RGSPGVRAAH KLPRHRPLNR 450
TQSAPLPQST LAQLVIQQQH QQFLEKQKQY QQQIHMNKML SKSIEQLKQP 500
GSHLEEAEEE LNGDHSMQEE RAPASSASIR AESSSAGEDD RIGQQVGAVK 550
VKEEPPDSDE DTQTQQMESG EQAAFVQQVI GKDLAPGFVI KVII 594
Length:594
Mass (Da):66,214
Last modified:November 23, 2004 - v1
Checksum:iC3BA308AA746BA5E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720108 mRNA. Translation: CAG31767.1.
UniGeneiGga.1378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720108 mRNA. Translation: CAG31767.1 .
UniGenei Gga.1378.

3D structure databases

ProteinModelPortali Q5ZKH6.
SMRi Q5ZKH6. Positions 37-104.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000017619.

Proteomic databases

PaxDbi Q5ZKH6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0123.
HOGENOMi HOG000232065.
HOVERGENi HBG057100.
PhylomeDBi Q5ZKH6.

Family and domain databases

InterProi IPR000286. His_deacetylse.
IPR024643. Hist_deacetylase_Gln_rich_N.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF12203. HDAC4_Gln. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiHDAC9_CHICK
AccessioniPrimary (citable) accession number: Q5ZKH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi