Q5ZKG5 (PPAC_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low molecular weight phosphotyrosine protein phosphatase
Short name=LMW-PTP
Short name=LMW-PTPase
EC=3.1.3.48

Alternative name(s):
Low molecular weight cytosolic acid phosphatase
EC=3.1.3.2

Gene names

Name:	ACP1
ORF Names:	RCJMB04_11a4

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphate monoester + H2O = an alcohol + phosphate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell internal side of plasma membrane Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	acid phosphatase activity Inferred from electronic annotation. Source: EC non-membrane spanning protein tyrosine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 158	157	Low molecular weight phosphotyrosine protein phosphatase		PRO_0000256846
Sites
	Active site	13	1	Nucleophile By similarity
	Active site	19	1	By similarity
	Active site	130	1	Proton donor By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	132	1	Phosphotyrosine By similarity
	Modified residue	133	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZKG5 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 8BC36CCA25984EB6	FASTA	158	18,196
	10 20 30 40 50 60 MAAGEVKSVL FVCLGNICRS PIAEAVFRKL VTDEKVENKW RIDSAATSTY EIGNPPDYRG 70 80 90 100 110 120 QTCMKKHGIT MNHIARQVTK DDFQTFDYIL CMDESNLRDL KRKSNQVKDC KAKIELLGAY 130 140 150 DPQKQLIIED PYYGNEKDFE TVYEQCVRCC KAFLEKPH

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ720119 mRNA. Translation: CAG31778.1.
IPI	IPI00578195.
RefSeq	NP_001034380.1. NM_001039291.1.
UniGene	Gga.23765.
3D structure databases
ProteinModelPortal	Q5ZKG5.
SMR	Q5ZKG5. Positions 2-158.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000026345.
Proteomic databases
PaxDb	Q5ZKG5.
PRIDE	Q5ZKG5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000026395; ENSGALP00000026345; ENSGALG00000016363.
GeneID	421909.
KEGG	gga:421909.
Organism-specific databases
CTD	52.
Phylogenomic databases
eggNOG	COG0394.
GeneTree	ENSGT00500000044891.
HOGENOM	HOG000273094.
HOVERGEN	HBG007540.
InParanoid	Q5ZKG5.
KO	K14394.
OMA	YEIGSPP.
OrthoDB	EOG4DR9DN.
Family and domain databases
InterPro	IPR023485. Ptyr_pPase_SF. IPR002115. Tyr_Pase_low_mol_wt_mml. IPR000106. Tyr_phospatase/Ars_reductase. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. PTHR11717. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
PRINTS	PR00719. LMWPTPASE. PR00720. MAMMALPTPASE.
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
ProtoNet	Search...
Other
NextBio	20824616.

Entry information

Entry name

PPAC_CHICK

Accession

Primary (citable) accession number: Q5ZKG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	January 23, 2007
Last modified:	May 29, 2013
This is version 56 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program