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Q5ZKG5 (PPAC_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low molecular weight phosphotyrosine protein phosphatase

Short name=LMW-PTP
Short name=LMW-PTPase
EC=3.1.3.48
Alternative name(s):
Low molecular weight cytosolic acid phosphatase
EC=3.1.3.2
Gene names
Name:ACP1
ORF Names:RCJMB04_11a4
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

A phosphate monoester + H2O = an alcohol + phosphate.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 158157Low molecular weight phosphotyrosine protein phosphatase
PRO_0000256846

Sites

Active site131Nucleophile By similarity
Active site191 By similarity
Active site1301Proton donor By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1321Phosphotyrosine By similarity
Modified residue1331Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZKG5 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 8BC36CCA25984EB6

FASTA15818,196
        10         20         30         40         50         60 
MAAGEVKSVL FVCLGNICRS PIAEAVFRKL VTDEKVENKW RIDSAATSTY EIGNPPDYRG 

        70         80         90        100        110        120 
QTCMKKHGIT MNHIARQVTK DDFQTFDYIL CMDESNLRDL KRKSNQVKDC KAKIELLGAY 

       130        140        150 
DPQKQLIIED PYYGNEKDFE TVYEQCVRCC KAFLEKPH 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ720119 mRNA. Translation: CAG31778.1.
RefSeqNP_001034380.1. NM_001039291.1.
UniGeneGga.23765.

3D structure databases

ProteinModelPortalQ5ZKG5.
SMRQ5ZKG5. Positions 2-158.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid682668. 1 interaction.
STRING9031.ENSGALP00000026345.

Proteomic databases

PaxDbQ5ZKG5.
PRIDEQ5ZKG5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000026395; ENSGALP00000026345; ENSGALG00000016363.
GeneID421909.
KEGGgga:421909.

Organism-specific databases

CTD52.

Phylogenomic databases

eggNOGCOG0394.
GeneTreeENSGT00500000044891.
HOGENOMHOG000273094.
HOVERGENHBG007540.
InParanoidQ5ZKG5.
KOK14394.
OMACELAPEM.
OrthoDBEOG7QZGCG.
PhylomeDBQ5ZKG5.
TreeFamTF353727.

Family and domain databases

InterProIPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. PTHR11717. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
ProtoNetSearch...

Other

NextBio20824616.

Entry information

Entry namePPAC_CHICK
AccessionPrimary (citable) accession number: Q5ZKG5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 63 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families