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Q5ZKG5

- PPAC_CHICK

UniProt

Q5ZKG5 - PPAC_CHICK

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Protein

Low molecular weight phosphotyrosine protein phosphatase

Gene

ACP1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei13 – 131NucleophileBy similarity
Active sitei19 – 191By similarity
Active sitei130 – 1301Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. non-membrane spanning protein tyrosine phosphatase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight phosphotyrosine protein phosphatase (EC:3.1.3.48)
Short name:
LMW-PTP
Short name:
LMW-PTPase
Alternative name(s):
Low molecular weight cytosolic acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:ACP1
ORF Names:RCJMB04_11a4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 3

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoplasmic side of plasma membrane Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 158157Low molecular weight phosphotyrosine protein phosphatasePRO_0000256846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei132 – 1321PhosphotyrosineBy similarity
Modified residuei133 – 1331PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5ZKG5.
PRIDEiQ5ZKG5.

Interactioni

Protein-protein interaction databases

BioGridi682668. 1 interaction.
STRINGi9031.ENSGALP00000026345.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKG5.
SMRiQ5ZKG5. Positions 2-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0394.
GeneTreeiENSGT00500000044891.
HOGENOMiHOG000273094.
HOVERGENiHBG007540.
InParanoidiQ5ZKG5.
KOiK14394.
OMAiCELAPEM.
OrthoDBiEOG7QZGCG.
PhylomeDBiQ5ZKG5.
TreeFamiTF353727.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF15. PTHR11717:SF15. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZKG5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAGEVKSVL FVCLGNICRS PIAEAVFRKL VTDEKVENKW RIDSAATSTY
60 70 80 90 100
EIGNPPDYRG QTCMKKHGIT MNHIARQVTK DDFQTFDYIL CMDESNLRDL
110 120 130 140 150
KRKSNQVKDC KAKIELLGAY DPQKQLIIED PYYGNEKDFE TVYEQCVRCC

KAFLEKPH
Length:158
Mass (Da):18,196
Last modified:January 23, 2007 - v3
Checksum:i8BC36CCA25984EB6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720119 mRNA. Translation: CAG31778.1.
RefSeqiNP_001034380.1. NM_001039291.1.
UniGeneiGga.23765.

Genome annotation databases

EnsembliENSGALT00000026395; ENSGALP00000026345; ENSGALG00000016363.
GeneIDi421909.
KEGGigga:421909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720119 mRNA. Translation: CAG31778.1 .
RefSeqi NP_001034380.1. NM_001039291.1.
UniGenei Gga.23765.

3D structure databases

ProteinModelPortali Q5ZKG5.
SMRi Q5ZKG5. Positions 2-158.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 682668. 1 interaction.
STRINGi 9031.ENSGALP00000026345.

Proteomic databases

PaxDbi Q5ZKG5.
PRIDEi Q5ZKG5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000026395 ; ENSGALP00000026345 ; ENSGALG00000016363 .
GeneIDi 421909.
KEGGi gga:421909.

Organism-specific databases

CTDi 52.

Phylogenomic databases

eggNOGi COG0394.
GeneTreei ENSGT00500000044891.
HOGENOMi HOG000273094.
HOVERGENi HBG007540.
InParanoidi Q5ZKG5.
KOi K14394.
OMAi CELAPEM.
OrthoDBi EOG7QZGCG.
PhylomeDBi Q5ZKG5.
TreeFami TF353727.

Miscellaneous databases

NextBioi 20824616.

Family and domain databases

InterProi IPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717:SF15. PTHR11717:SF15. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
PRINTSi PR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiPPAC_CHICK
AccessioniPrimary (citable) accession number: Q5ZKG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 65 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3