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Protein

Low molecular weight phosphotyrosine protein phosphatase

Gene

ACP1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei13 – 131NucleophileBy similarity
Active sitei19 – 191By similarity
Active sitei130 – 1301Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. non-membrane spanning protein tyrosine phosphatase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight phosphotyrosine protein phosphatase (EC:3.1.3.48)
Short name:
LMW-PTP
Short name:
LMW-PTPase
Alternative name(s):
Low molecular weight cytosolic acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:ACP1
ORF Names:RCJMB04_11a4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 3

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. cytoplasmic side of plasma membrane Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 158157Low molecular weight phosphotyrosine protein phosphatasePRO_0000256846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei132 – 1321PhosphotyrosineBy similarity
Modified residuei133 – 1331PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5ZKG5.
PRIDEiQ5ZKG5.

Interactioni

Protein-protein interaction databases

BioGridi682668. 1 interaction.
STRINGi9031.ENSGALP00000026345.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKG5.
SMRiQ5ZKG5. Positions 2-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0394.
GeneTreeiENSGT00500000044891.
HOGENOMiHOG000273094.
HOVERGENiHBG007540.
InParanoidiQ5ZKG5.
KOiK14394.
OMAiENKWRID.
OrthoDBiEOG7QZGCG.
PhylomeDBiQ5ZKG5.
TreeFamiTF353727.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF15. PTHR11717:SF15. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZKG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGEVKSVL FVCLGNICRS PIAEAVFRKL VTDEKVENKW RIDSAATSTY
60 70 80 90 100
EIGNPPDYRG QTCMKKHGIT MNHIARQVTK DDFQTFDYIL CMDESNLRDL
110 120 130 140 150
KRKSNQVKDC KAKIELLGAY DPQKQLIIED PYYGNEKDFE TVYEQCVRCC

KAFLEKPH
Length:158
Mass (Da):18,196
Last modified:January 23, 2007 - v3
Checksum:i8BC36CCA25984EB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720119 mRNA. Translation: CAG31778.1.
RefSeqiNP_001034380.1. NM_001039291.1.
UniGeneiGga.23765.

Genome annotation databases

EnsembliENSGALT00000026395; ENSGALP00000026345; ENSGALG00000016363.
GeneIDi421909.
KEGGigga:421909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720119 mRNA. Translation: CAG31778.1.
RefSeqiNP_001034380.1. NM_001039291.1.
UniGeneiGga.23765.

3D structure databases

ProteinModelPortaliQ5ZKG5.
SMRiQ5ZKG5. Positions 2-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi682668. 1 interaction.
STRINGi9031.ENSGALP00000026345.

Proteomic databases

PaxDbiQ5ZKG5.
PRIDEiQ5ZKG5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000026395; ENSGALP00000026345; ENSGALG00000016363.
GeneIDi421909.
KEGGigga:421909.

Organism-specific databases

CTDi52.

Phylogenomic databases

eggNOGiCOG0394.
GeneTreeiENSGT00500000044891.
HOGENOMiHOG000273094.
HOVERGENiHBG007540.
InParanoidiQ5ZKG5.
KOiK14394.
OMAiENKWRID.
OrthoDBiEOG7QZGCG.
PhylomeDBiQ5ZKG5.
TreeFamiTF353727.

Miscellaneous databases

NextBioi20824616.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF15. PTHR11717:SF15. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiPPAC_CHICK
AccessioniPrimary (citable) accession number: Q5ZKG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.