Q5ZKF6 (5NT3L_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytosolic 5'-nucleotidase III-like protein
Short name=cN-III-like protein
EC=3.1.3.5

Gene names

Name:	NT5C3L
ORF Names:	RCJMB04_11c18

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Can act both as nucleotidase and as phosphotransferase By similarity.
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the pyrimidine 5'-nucleotidase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Cytosolic 5'-nucleotidase III-like protein		PRO_0000328951
Regions
	Region	153 – 154	2	Substrate binding By similarity
Sites
	Active site	38	1	Nucleophile By similarity
	Active site	40	1	Proton donor By similarity
	Metal binding	38	1	Magnesium By similarity
	Metal binding	40	1	Magnesium; via carbonyl oxygen By similarity
	Metal binding	227	1	Magnesium By similarity
	Binding site	202	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZKF6 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 9DF06DC1F6EF099E	FASTA	289	33,109
	10 20 30 40 50 60 MVPELQKSTV RIQQPERVMG VIRAIKEQGC SKLQVISDFD MTLSRFGCNG RRCPTSHNIL 70 80 90 100 110 120 DNSHVISEDG KKKLKDLLHH YYPIEIDPNR TLEEKRPLMV EWWTRAHELL SQQKIQKGDI 130 140 150 160 170 180 AQIVRESDVM LRDGFNELFD QLHKYSVPMF IFSAGVGDVL EEIIRQANVF YPNVNVVSNY 190 200 210 220 230 240 MDFDDSGVLK CFKSPLIHTY NKNNSVLQGT AYFQQLSTRT SIILLGDSMG DLTMADGVPS 250 260 270 280 VENILKIGFL NDKVEEQRGR YLDAYDIVLE SDETLDVVNG ILRYILMET

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ720128 mRNA. Translation: CAG31787.1.
IPI	IPI00584810.
RefSeq	NP_001006334.1. NM_001006334.1.
UniGene	Gga.4321.
3D structure databases
HSSP	HSSP built from PDB template 2CN1 based on UniProtKB Q9UC45.
ProteinModelPortal	Q5ZKF6.
SMR	Q5ZKF6. Positions 1-286.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000005786; ENSGALP00000005776; ENSGALG00000003651.
GeneID	420034.
KEGG	gga:420034.
Organism-specific databases
CTD	115024.
Phylogenomic databases
eggNOG	veNOG13850.
GeneTree	ENSGT00390000012959.
HOGENOM	HBG382723.
HOVERGEN	HBG059750.
InParanoid	Q5ZKF6.
OMA	QLQGKTN.
OrthoDB	EOG4JWVDW.
Family and domain databases
InterPro	IPR023214. HAD-like_dom. IPR006434. Pyrimidine_nucleotidase_eu. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 1 hit.
PANTHER	PTHR13045. HAD-SF_hydro_IE. 1 hit.
Pfam	PF05822. UMPH-1. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01544. HAD-SF-IE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

5NT3L_CHICK

Accession

Primary (citable) accession number: Q5ZKF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	November 23, 2004
Last modified:	September 21, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program