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Protein

Putative helicase MOV-10

Gene

MOV10

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi516 – 5238ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

RNA-mediated gene silencing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative helicase MOV-10 (EC:3.6.4.13)
Gene namesi
Name:MOV10
ORF Names:RCJMB04_11i10
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 967967Putative helicase MOV-10PRO_0000374667Add
BLAST

Proteomic databases

PaxDbiQ5ZKD7.
PRIDEiQ5ZKD7.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002366.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi638 – 6414DEAG box

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1804. Eukaryota.
COG1112. LUCA.
HOGENOMiHOG000239755.
InParanoidiQ5ZKD7.
KOiK18422.
PhylomeDBiQ5ZKD7.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR026122. MOV-10.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10887:SF322. PTHR10887:SF322. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZKD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRFSVAEAR RYGDQFVQFL RDPSREQESR REVLRDIYSQ EFRTRTDIRT
60 70 80 90 100
PSFSSILYAL RVSHQAQVHG QTVHFKKARR RVVVADQYRR PRTDTEVSAP
110 120 130 140 150
APGQQPSSGP PAPQSRAKKW AEFIRGKHGV EIVSEYDQAN GQIRFPVALD
160 170 180 190 200
KTKTFTVQVQ NHGAEAVTLH RCRPLRRLQE LSFLDEQGVT QGQALVLHPG
210 220 230 240 250
GAYPIQVRCL TSHNGFFRAV VMFEFSKEPD GSFSIGRSIA AIAQSPLARE
260 270 280 290 300
LGPSAPYRPY QASLQRPITV VTEDGVPPVS SLKNELEKEI PLGTYPYPKS
310 320 330 340 350
LKETIMLGPK TSPDSSWMKM QSLLEAPLQP ENYKQKFELL LHLEEIQLEV
360 370 380 390 400
DIRRYDLQEV PMVQNRALLL LNVPGVAENR PSVLRGDHLF ASLSSERDSS
410 420 430 440 450
PRVLYKGYVH GVELERVQLG FSPKLMKKFV NDLKFDVTFT FNRLPLQVQH
460 470 480 490 500
RAAAMAMQKG LDSVLFPSAS CQRSLFTGIF QPRWFDRKVE ANEEQCQAVK
510 520 530 540 550
HIVTGMSRPA PYLIFGPPGT GKTVTLVEAI KQVWSCFKDA RILACAPSNS
560 570 580 590 600
AADLLCQRLL TNIAPRYIYR IMASSANYKD VPADVRPCCN WDDSEKCYVY
610 620 630 640 650
PSKKLLKPYR ILITTLVTAG RLVSANFPPG YFSHVFIDEC GHAVEPESVV
660 670 680 690 700
AIAGLLTTMD PDTNPNGGQL VLAGDPQQLG PVPRSPLAAQ HGLGTSLLER
710 720 730 740 750
LMLHNALYAK SDEGYNPQFV TKLLWNYRSH KAILKVPNEL FYDSELKAYE
760 770 780 790 800
GSEPDVRNFY CTWEELPNRG VPIIFHGVCG EDEREAKSPS FFNTAEIEVV
810 820 830 840 850
VQYLQKLLQS QGRRGCPTIS PKEIGIISPY RKQVEKIRLA ITSKDPVLRA
860 870 880 890 900
LPDIGQLKVG SVEEFQGQER RVILISTVRS CSEYLQLDQT FRLGFLKNPK
910 920 930 940 950
RLNVALTRAK ALLIVVGNAA VLSKDPHWHR FLRYCRDEGA YRGYPYEEEP
960
PEEDSLANHL DSLHLGN
Length:967
Mass (Da):109,051
Last modified:November 23, 2004 - v1
Checksum:iE894F36240C094FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720147 mRNA. Translation: CAG31806.1.
RefSeqiNP_001012861.1. NM_001012843.1.
UniGeneiGga.1182.

Genome annotation databases

GeneIDi419872.
KEGGigga:419872.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720147 mRNA. Translation: CAG31806.1.
RefSeqiNP_001012861.1. NM_001012843.1.
UniGeneiGga.1182.

3D structure databases

ProteinModelPortaliQ5ZKD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002366.

Proteomic databases

PaxDbiQ5ZKD7.
PRIDEiQ5ZKD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi419872.
KEGGigga:419872.

Organism-specific databases

CTDi4343.

Phylogenomic databases

eggNOGiKOG1804. Eukaryota.
COG1112. LUCA.
HOGENOMiHOG000239755.
InParanoidiQ5ZKD7.
KOiK18422.
PhylomeDBiQ5ZKD7.

Miscellaneous databases

PROiQ5ZKD7.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR026122. MOV-10.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10887:SF322. PTHR10887:SF322. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiMOV10_CHICK
AccessioniPrimary (citable) accession number: Q5ZKD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.